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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ekaSAHDiphthine synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ekaSAHDiphthine synthase/1.000
2emrSAHDiphthine synthase/0.827
2p6dSAHDiphthine synthase/0.827
2ehlSAHDiphthine synthase/0.795
2eniSAHDiphthine synthase/0.792
2eleSAHDiphthine synthase/0.782
2dxvSAHDiphthine synthase/0.781
2e7rSAHDiphthine synthase/0.780
2pcmSAHDiphthine synthase/0.768
2dxwSAHDiphthine synthase/0.767
2eh5SAHDiphthine synthase/0.767
2egbSAHDiphthine synthase/0.759
2ejkSAHDiphthine synthase/0.756
2pcgSAHDiphthine synthase/0.748
2egsSAHDiphthine synthase/0.746
2emuSAHDiphthine synthase/0.736
2dv7SAHDiphthine synthase/0.731
2p2xSAHDiphthine synthase/0.729
2p5cSAHDiphthine synthase/0.723
2dxxSAHDiphthine synthase/0.716
2p5fSAHDiphthine synthase/0.713
2pckSAHDiphthine synthase/0.710
2owkSAHDiphthine synthase/0.703
2e8rSAHDiphthine synthase/0.701
2e8sSAHDiphthine synthase/0.700
2ek7SAHDiphthine synthase/0.700
2eh2SAHDiphthine synthase/0.697
2ed5SAHDiphthine synthase/0.692
2eglSAHDiphthine synthase/0.690
2dsgSAHDiphthine synthase/0.684
2e8qSAHDiphthine synthase/0.684
2pb4SAHDiphthine synthase/0.683
2e08SAHDiphthine synthase/0.680
2p6kSAHDiphthine synthase/0.680
2pchSAHDiphthine synthase/0.666
2eldSAHDiphthine synthase/0.659
2p6iSAHDiphthine synthase/0.658
2el0SAHDiphthine synthase/0.655
2dv4SAHDiphthine synthase/0.651
2e16SAHDiphthine synthase/0.650
2dv3SAHDiphthine synthase/0.647
1vceSAHDiphthine synthase/0.646
2huxSAHDiphthine synthase/0.646
2p9dSAHDiphthine synthase/0.646
2owgSAHDiphthine synthase/0.643
2pb6SAHDiphthine synthase/0.642
2hr8SAHDiphthine synthase/0.641
2dv5SAHDiphthine synthase/0.638
2el3SAHDiphthine synthase/0.635
2hutSAHDiphthine synthase/0.634
2en5SAHDiphthine synthase/0.630
2pciSAHDiphthine synthase/0.628
2ek2SAHDiphthine synthase/0.625
2owvSAHDiphthine synthase/0.624
1wngSAHDiphthine synthase/0.621
2dsiSAHDiphthine synthase/0.614
2huvSAHDiphthine synthase/0.609
2eh4SAHDiphthine synthase/0.606
2ek4SAHDiphthine synthase/0.606
2pcaSAHDiphthine synthase/0.606
2e4nSAHDiphthine synthase/0.605
2ek3SAHDiphthine synthase/0.600
2e8hSAHDiphthine synthase/0.595
2e15SAHDiphthine synthase/0.592
2dekSAHDiphthine synthase/0.585
2e17SAHDiphthine synthase/0.585
2ejjSAHDiphthine synthase/0.572
2z6rSAHDiphthine synthase/0.569
2owuSAHDiphthine synthase/0.567
2huqSAHDiphthine synthase/0.565
2e07SAHDiphthine synthase/0.564
2pb5SAHDiphthine synthase/0.563
2eeqSAHDiphthine synthase/0.559
2p6lSAHDiphthine synthase/0.550
2dshSAHDiphthine synthase/0.545
2owfSAHDiphthine synthase/0.529
2ejzSAHDiphthine synthase/0.527
2ed3SAHDiphthine synthase/0.497
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.473
1bwsNDPGDP-L-fucose synthase/0.470
3zh8C58Protein kinase C iota type2.7.11.130.469
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.463
2hfuMEVMevalonate kinase/0.460
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3fwiCAMCamphor 5-monooxygenase1.14.15.10.451
3jynNDPQuinone oxidoreductase/0.451
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.450
4cp4CAMCamphor 5-monooxygenase1.14.15.10.450
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.449
1e7qNAPGDP-L-fucose synthase/0.449
2pj4414Carboxypeptidase B/0.449
3ieuGDPGTPase Era/0.449
1nooCAHCamphor 5-monooxygenase1.14.15.10.448
1fxsNAPGDP-L-fucose synthase/0.447
1g1aNADdTDP-glucose 4,6-dehydratase/0.447
3lqfNADGalactitol dehydrogenase/0.447
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.447
1pjcNADAlanine dehydrogenase/0.446
1tehNADAlcohol dehydrogenase class-31.1.1.10.446
2ejvNADL-threonine 3-dehydrogenase/0.446
2q4bNAPUncharacterized protein At5g02240/0.446
3b70NAPEnoyl reductase LovC10.445
3gqvNAPEnoyl reductase LovC10.445
1me6IVSPlasmepsin-23.4.23.390.444
1xddAAYIntegrin alpha-L/0.444
3c1y2BADNA integrity scanning protein DisA/0.444
2nniMTKCytochrome P450 2C8/0.442
2rhgIGPTryptophan synthase alpha chain/0.442
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.442
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.441
2a1nCAMCamphor 5-monooxygenase1.14.15.10.441
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.441
2rh9IGPTryptophan synthase alpha chain/0.441
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.441
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.441
4q71FADBifunctional protein PutA/0.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440