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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e17SAHDiphthine synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2e17SAHDiphthine synthase/1.000
2owuSAHDiphthine synthase/0.819
2z6rSAHDiphthine synthase/0.818
2e15SAHDiphthine synthase/0.816
2ek2SAHDiphthine synthase/0.799
2eeqSAHDiphthine synthase/0.784
2dsiSAHDiphthine synthase/0.783
2owkSAHDiphthine synthase/0.765
2e07SAHDiphthine synthase/0.754
2e4nSAHDiphthine synthase/0.748
2ed5SAHDiphthine synthase/0.746
2hutSAHDiphthine synthase/0.739
2emuSAHDiphthine synthase/0.738
2pb6SAHDiphthine synthase/0.737
2ek3SAHDiphthine synthase/0.726
2dv4SAHDiphthine synthase/0.721
2dv5SAHDiphthine synthase/0.721
2eh2SAHDiphthine synthase/0.721
2p6iSAHDiphthine synthase/0.716
1wngSAHDiphthine synthase/0.713
2eh4SAHDiphthine synthase/0.704
2huvSAHDiphthine synthase/0.700
2el0SAHDiphthine synthase/0.695
2huqSAHDiphthine synthase/0.695
2p5cSAHDiphthine synthase/0.695
2dekSAHDiphthine synthase/0.692
2e8rSAHDiphthine synthase/0.692
2dsgSAHDiphthine synthase/0.690
2eh5SAHDiphthine synthase/0.686
2ejjSAHDiphthine synthase/0.682
2ehlSAHDiphthine synthase/0.681
2owgSAHDiphthine synthase/0.678
2eniSAHDiphthine synthase/0.676
2p5fSAHDiphthine synthase/0.674
2dv7SAHDiphthine synthase/0.671
2emrSAHDiphthine synthase/0.671
2p6lSAHDiphthine synthase/0.669
2dxxSAHDiphthine synthase/0.663
2el3SAHDiphthine synthase/0.662
2eldSAHDiphthine synthase/0.657
2p9dSAHDiphthine synthase/0.656
2ejkSAHDiphthine synthase/0.653
2pcaSAHDiphthine synthase/0.652
2ed3SAHDiphthine synthase/0.645
1vceSAHDiphthine synthase/0.643
2dshSAHDiphthine synthase/0.641
2p6kSAHDiphthine synthase/0.641
2pciSAHDiphthine synthase/0.638
2pckSAHDiphthine synthase/0.635
2p2xSAHDiphthine synthase/0.634
2e8hSAHDiphthine synthase/0.632
2ek4SAHDiphthine synthase/0.632
2dxwSAHDiphthine synthase/0.628
2hr8SAHDiphthine synthase/0.628
2e16SAHDiphthine synthase/0.625
2dxvSAHDiphthine synthase/0.616
2eleSAHDiphthine synthase/0.616
2e8qSAHDiphthine synthase/0.615
2p6dSAHDiphthine synthase/0.613
2ek7SAHDiphthine synthase/0.612
2e7rSAHDiphthine synthase/0.609
2huxSAHDiphthine synthase/0.608
2owvSAHDiphthine synthase/0.607
2e08SAHDiphthine synthase/0.606
2egsSAHDiphthine synthase/0.598
2pb4SAHDiphthine synthase/0.592
2e8sSAHDiphthine synthase/0.584
2dv3SAHDiphthine synthase/0.582
2pcmSAHDiphthine synthase/0.582
2ekaSAHDiphthine synthase/0.578
2pcgSAHDiphthine synthase/0.572
2eglSAHDiphthine synthase/0.571
2en5SAHDiphthine synthase/0.568
2owfSAHDiphthine synthase/0.566
2pchSAHDiphthine synthase/0.563
2egbSAHDiphthine synthase/0.554
2ejzSAHDiphthine synthase/0.540
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.477
1f8fNADBenzyl alcohol dehydrogenase/0.468
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.466
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.465
4q71FADBifunctional protein PutA/0.465
2b8l5HABeta-secretase 13.4.23.460.462
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.459
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.459
1pjcNADAlanine dehydrogenase/0.458
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.457
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.456
2znnS44Peroxisome proliferator-activated receptor alpha/0.456
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.455
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.455
1bil0IURenin3.4.23.150.454
3p62FMNPentaerythritol tetranitrate reductase/0.454
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.453
1w6hTITPlasmepsin-23.4.23.390.451
3gw9VNILanosterol 14-alpha-demethylase/0.450
3lqfNADGalactitol dehydrogenase/0.450
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.450
2y3sTIRTamL/0.448
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.448
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.448
1dr3HBIDihydrofolate reductase1.5.1.30.447
1g1aNADdTDP-glucose 4,6-dehydratase/0.447
1tj0FADBifunctional protein PutA1.5.5.20.447
1xddAAYIntegrin alpha-L/0.447
3to6LYS_CMCHistone acetyltransferase ESA1/0.447
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.447
1fxsNAPGDP-L-fucose synthase/0.446
3tjzGNPADP-ribosylation factor 1/0.446
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.445
3fwiCAMCamphor 5-monooxygenase1.14.15.10.445
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.444
1dr2TAPDihydrofolate reductase1.5.1.30.444
1yrcCAMCamphor 5-monooxygenase1.14.15.10.443
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.443
3zh8C58Protein kinase C iota type2.7.11.130.443
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4jl5ADPAdenylate kinase/0.443
1xl5190Gag-Pol polyprotein3.4.23.160.442
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.442
3vqsJT1Genome polyprotein/0.442
3w6hAZMCarbonic anhydrase 14.2.1.10.442
1beuIPLTryptophan synthase alpha chain/0.441
3slkNDPPolyketide synthase extender module 2/0.441
4gxs0YSGlutamate receptor 2/0.441
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.441
1xe65FPPlasmepsin-23.4.23.390.440
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.440
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4qecNAPElxO/0.440
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440