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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e15SAHDiphthine synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2e15SAHDiphthine synthase/1.000
2e17SAHDiphthine synthase/0.795
2dv5SAHDiphthine synthase/0.787
2ek3SAHDiphthine synthase/0.769
2hutSAHDiphthine synthase/0.757
2owkSAHDiphthine synthase/0.754
2dsiSAHDiphthine synthase/0.751
2owuSAHDiphthine synthase/0.751
2e8rSAHDiphthine synthase/0.735
2p6iSAHDiphthine synthase/0.732
2owgSAHDiphthine synthase/0.730
2z6rSAHDiphthine synthase/0.725
2emuSAHDiphthine synthase/0.717
2huqSAHDiphthine synthase/0.717
2p5cSAHDiphthine synthase/0.707
2p9dSAHDiphthine synthase/0.706
2ek2SAHDiphthine synthase/0.705
2dekSAHDiphthine synthase/0.699
2huvSAHDiphthine synthase/0.699
2dsgSAHDiphthine synthase/0.698
2eeqSAHDiphthine synthase/0.697
2e07SAHDiphthine synthase/0.694
2eh2SAHDiphthine synthase/0.690
2pckSAHDiphthine synthase/0.689
2emrSAHDiphthine synthase/0.686
2el3SAHDiphthine synthase/0.682
2eh5SAHDiphthine synthase/0.681
2dshSAHDiphthine synthase/0.678
2e4nSAHDiphthine synthase/0.678
2pb5SAHDiphthine synthase/0.676
2dxxSAHDiphthine synthase/0.675
2ed5SAHDiphthine synthase/0.671
2eh4SAHDiphthine synthase/0.667
2ehlSAHDiphthine synthase/0.667
2eldSAHDiphthine synthase/0.667
2p5fSAHDiphthine synthase/0.665
2e08SAHDiphthine synthase/0.664
2e8hSAHDiphthine synthase/0.663
2dv7SAHDiphthine synthase/0.662
2eniSAHDiphthine synthase/0.659
2p6lSAHDiphthine synthase/0.655
2e7rSAHDiphthine synthase/0.651
2eleSAHDiphthine synthase/0.649
2pb6SAHDiphthine synthase/0.649
1vceSAHDiphthine synthase/0.646
2p2xSAHDiphthine synthase/0.638
2p6dSAHDiphthine synthase/0.638
2hr8SAHDiphthine synthase/0.636
2pcaSAHDiphthine synthase/0.632
1wngSAHDiphthine synthase/0.624
2dv4SAHDiphthine synthase/0.621
2egbSAHDiphthine synthase/0.621
2p6kSAHDiphthine synthase/0.621
2pcgSAHDiphthine synthase/0.618
2ejjSAHDiphthine synthase/0.615
2ejkSAHDiphthine synthase/0.613
2dxvSAHDiphthine synthase/0.610
2owvSAHDiphthine synthase/0.602
2el0SAHDiphthine synthase/0.601
2e16SAHDiphthine synthase/0.600
2ek4SAHDiphthine synthase/0.598
2ekaSAHDiphthine synthase/0.597
2pciSAHDiphthine synthase/0.597
2egsSAHDiphthine synthase/0.595
2pcmSAHDiphthine synthase/0.586
2huxSAHDiphthine synthase/0.578
2dv3SAHDiphthine synthase/0.577
2ed3SAHDiphthine synthase/0.572
2dxwSAHDiphthine synthase/0.571
2pchSAHDiphthine synthase/0.550
2eglSAHDiphthine synthase/0.549
2owfSAHDiphthine synthase/0.549
2pb4SAHDiphthine synthase/0.540
2ejzSAHDiphthine synthase/0.535
2e8sSAHDiphthine synthase/0.531
2ek7SAHDiphthine synthase/0.518
2e8qSAHDiphthine synthase/0.512
2en5SAHDiphthine synthase/0.502
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
1xddAAYIntegrin alpha-L/0.467
1xe55FEPlasmepsin-23.4.23.390.466
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.457
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.457
1nooCAHCamphor 5-monooxygenase1.14.15.10.454
1t86CAMCamphor 5-monooxygenase1.14.15.10.454
3fwiCAMCamphor 5-monooxygenase1.14.15.10.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.452
3ziuLSSLeucyl-tRNA synthetase/0.452
5dp2NAPCurF/0.452
2ifaFMNUncharacterized protein/0.451
4ougLP5Peptidoglycan recognition protein 1/0.451
2givACOHistone acetyltransferase KAT8/0.449
3to6LYS_CMCHistone acetyltransferase ESA1/0.448
3zh8C58Protein kinase C iota type2.7.11.130.448
2hfuMEVMevalonate kinase/0.447
2gjlFMNNitronate monooxygenase1.13.12.160.446
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3lqfNADGalactitol dehydrogenase/0.446
1me6IVSPlasmepsin-23.4.23.390.444
1t87CAMCamphor 5-monooxygenase1.14.15.10.444
4lcjNADC-terminal-binding protein 2/0.444
1t88CAMCamphor 5-monooxygenase1.14.15.10.443
3fwgCAMCamphor 5-monooxygenase1.14.15.10.443
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.443
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
4eb5PLPCysteine desulfurase IscS 2/0.443
1yqzCOACoenzyme A disulfide reductase/0.442
2ou2ACOHistone acetyltransferase KAT5/0.442
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.442
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.442
3px3T3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase2.1.1.2350.442
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.442
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3in6FMNUncharacterized protein/0.441
1f8fNADBenzyl alcohol dehydrogenase/0.440
2qbmCAMCamphor 5-monooxygenase1.14.15.10.440