sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2dxw | SAH | Diphthine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2dxw | SAH | Diphthine synthase | / | 1.000 | |
| 2dxv | SAH | Diphthine synthase | / | 0.911 | |
| 2e8s | SAH | Diphthine synthase | / | 0.878 | |
| 2emr | SAH | Diphthine synthase | / | 0.859 | |
| 2eni | SAH | Diphthine synthase | / | 0.834 | |
| 2el0 | SAH | Diphthine synthase | / | 0.828 | |
| 2ejk | SAH | Diphthine synthase | / | 0.818 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.816 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.811 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.810 | |
| 2pcm | SAH | Diphthine synthase | / | 0.808 | |
| 2p6k | SAH | Diphthine synthase | / | 0.806 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.804 | |
| 2p6d | SAH | Diphthine synthase | / | 0.798 | |
| 2e8q | SAH | Diphthine synthase | / | 0.797 | |
| 2ehl | SAH | Diphthine synthase | / | 0.794 | |
| 2egs | SAH | Diphthine synthase | / | 0.789 | |
| 2emu | SAH | Diphthine synthase | / | 0.782 | |
| 2egl | SAH | Diphthine synthase | / | 0.777 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.769 | |
| 2dsg | SAH | Diphthine synthase | / | 0.767 | |
| 2en5 | SAH | Diphthine synthase | / | 0.761 | |
| 2eka | SAH | Diphthine synthase | / | 0.760 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.760 | |
| 2p5c | SAH | Diphthine synthase | / | 0.752 | |
| 2p2x | SAH | Diphthine synthase | / | 0.743 | |
| 1wng | SAH | Diphthine synthase | / | 0.733 | |
| 2p5f | SAH | Diphthine synthase | / | 0.729 | |
| 2egb | SAH | Diphthine synthase | / | 0.725 | |
| 2e7r | SAH | Diphthine synthase | / | 0.722 | |
| 2hux | SAH | Diphthine synthase | / | 0.713 | |
| 2owk | SAH | Diphthine synthase | / | 0.704 | |
| 2owv | SAH | Diphthine synthase | / | 0.704 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.703 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.699 | |
| 2ele | SAH | Diphthine synthase | / | 0.698 | |
| 2e08 | SAH | Diphthine synthase | / | 0.692 | |
| 2dxx | SAH | Diphthine synthase | / | 0.690 | |
| 2e16 | SAH | Diphthine synthase | / | 0.690 | |
| 2pcg | SAH | Diphthine synthase | / | 0.690 | |
| 2pch | SAH | Diphthine synthase | / | 0.687 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.682 | |
| 2dsi | SAH | Diphthine synthase | / | 0.680 | |
| 2pca | SAH | Diphthine synthase | / | 0.672 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.671 | |
| 2p6i | SAH | Diphthine synthase | / | 0.671 | |
| 1vce | SAH | Diphthine synthase | / | 0.667 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.658 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.657 | |
| 2pck | SAH | Diphthine synthase | / | 0.656 | |
| 2z6r | SAH | Diphthine synthase | / | 0.652 | |
| 2owg | SAH | Diphthine synthase | / | 0.651 | |
| 2owu | SAH | Diphthine synthase | / | 0.649 | |
| 2e8h | SAH | Diphthine synthase | / | 0.648 | |
| 2hut | SAH | Diphthine synthase | / | 0.648 | |
| 2huv | SAH | Diphthine synthase | / | 0.647 | |
| 2p9d | SAH | Diphthine synthase | / | 0.643 | |
| 2e4n | SAH | Diphthine synthase | / | 0.642 | |
| 2eeq | SAH | Diphthine synthase | / | 0.638 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.636 | |
| 2ejj | SAH | Diphthine synthase | / | 0.635 | |
| 2pci | SAH | Diphthine synthase | / | 0.634 | |
| 2e17 | SAH | Diphthine synthase | / | 0.630 | |
| 2dek | SAH | Diphthine synthase | / | 0.629 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.629 | |
| 2eld | SAH | Diphthine synthase | / | 0.618 | |
| 2e8r | SAH | Diphthine synthase | / | 0.616 | |
| 2el3 | SAH | Diphthine synthase | / | 0.611 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.610 | |
| 2e07 | SAH | Diphthine synthase | / | 0.606 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.603 | |
| 2p6l | SAH | Diphthine synthase | / | 0.593 | |
| 2huq | SAH | Diphthine synthase | / | 0.589 | |
| 2owf | SAH | Diphthine synthase | / | 0.576 | |
| 2e15 | SAH | Diphthine synthase | / | 0.553 | |
| 2dsh | SAH | Diphthine synthase | / | 0.551 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.551 | |
| 2ejz | SAH | Diphthine synthase | / | 0.506 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.469 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.468 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.459 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.456 | |
| 2y3s | TIR | TamL | / | 0.455 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.455 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.454 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.453 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.452 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.451 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.450 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.450 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.449 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.448 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.446 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.446 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 4oug | LP5 | Peptidoglycan recognition protein 1 | / | 0.445 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.443 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.442 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.441 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.440 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.440 |