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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dv0ZSTAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2dv0ZSTAldose reductase1.1.1.211.000
2hv5ZSTAldose reductase1.1.1.210.800
2fz9ZSTAldose reductase1.1.1.210.792
2pdxZSTAldose reductase1.1.1.210.678
2fz8ZSTAldose reductase1.1.1.210.674
1z8962PAldose reductase1.1.1.210.666
3m64393Aldose reductase1.1.1.210.662
2ikj393Aldose reductase1.1.1.210.657
1t40ID5Aldose reductase1.1.1.210.655
1z3n3NAAldose reductase1.1.1.210.650
3lqlLDTAldose reductase1.1.1.210.635
3m4h388Aldose reductase1.1.1.210.630
4gca2X9Aldose reductase1.1.1.210.629
3lboLDTAldose reductase1.1.1.210.628
2ikhLITAldose reductase1.1.1.210.620
2hvoZSTAldose reductase1.1.1.210.615
2i16LDTAldose reductase1.1.1.210.613
3ghrLDTAldose reductase1.1.1.210.613
2iki388Aldose reductase1.1.1.210.611
3mb9ZSTAldose reductase1.1.1.210.611
3g5eQ74Aldose reductase1.1.1.210.608
1t41ID5Aldose reductase1.1.1.210.597
2pdh47DAldose reductase1.1.1.210.589
2pdp393Aldose reductase1.1.1.210.587
2pdu393Aldose reductase1.1.1.210.584
1ieiZESAldose reductase1.1.1.210.582
3ghsLDTAldose reductase1.1.1.210.582
3t423T4Aldose reductase1.1.1.210.582
2pzn393Aldose reductase1.1.1.210.581
2pdg47DAldose reductase1.1.1.210.573
3ld5LDTAldose reductase1.1.1.210.571
2pdbZSTAldose reductase1.1.1.210.569
2pdfZSTAldose reductase1.1.1.210.567
3ghuLDTAldose reductase1.1.1.210.567
1pwlBFIAldose reductase1.1.1.210.565
2fzdTOLAldose reductase1.1.1.210.564
1us0LDTAldose reductase1.1.1.210.563
3lenZSTAldose reductase1.1.1.210.556
2pdc393Aldose reductase1.1.1.210.553
2pdlTOLAldose reductase1.1.1.210.549
2pd5ZSTAldose reductase1.1.1.210.548
3m0iZSTAldose reductase1.1.1.210.545
3mc5393Aldose reductase1.1.1.210.542
2duzZSTAldose reductase1.1.1.210.538
2qxwLDTAldose reductase1.1.1.210.534
3ghtLDTAldose reductase1.1.1.210.533
2i17LDTAldose reductase1.1.1.210.531
2duxZSTAldose reductase1.1.1.210.529
3lz5LDTAldose reductase1.1.1.210.529
1frbZSTAldose reductase-related protein 2/0.525
4yu153NAldose reductase1.1.1.210.524
2pdn47DAldose reductase1.1.1.210.520
2pdq47DAldose reductase1.1.1.210.513
2pdj393Aldose reductase1.1.1.210.503
1ah3TOLAldose reductase1.1.1.210.484
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.483
2inzOHPAldose reductase1.1.1.210.473
2iqdLPAAldose reductase1.1.1.210.471
2fzbTOLAldose reductase1.1.1.210.460
4e0u0MVCyclic dipeptide N-prenyltransferase/0.459
5liu388Aldo-keto reductase family 1 member B101.1.10.459
1el3I84Aldose reductase1.1.1.210.458
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3mjrAC2Deoxycytidine kinase2.7.1.740.454
4phlPILPhosphodiesterase/0.454
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
4pnmNU1Tankyrase-22.4.2.300.452
2getCOKPantothenate kinase2.7.1.330.451
4u163C0Muscarinic acetylcholine receptor M3/0.451
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.450
2xujTZ5Acetylcholinesterase3.1.1.70.450
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.450
2aovC2MHistamine N-methyltransferase2.1.1.80.449
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2aotSAHHistamine N-methyltransferase2.1.1.80.448
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.446
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.446
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.446
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
2agtFIDAldose reductase1.1.1.210.444
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2ct8MSPMethionine--tRNA ligase6.1.1.100.443
2f3815MAldo-keto reductase family 1 member C3/0.443
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.443
2pdwFIDAldose reductase1.1.1.210.442
3zkyWT4Isopenicillin N synthase1.21.3.10.442
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2f2kTGGAldose reductase1.1.1.210.441
4j7gTRHPCZA361.3/0.441
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4jq4IMNAldo-keto reductase family 1 member C2/0.440