sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2d2i | NAP | Glyceraldehyde-3-phosphate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2d2i | NAP | Glyceraldehyde-3-phosphate dehydrogenase | / | 1.000 | |
| 1nq5 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.603 | |
| 1rm4 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.602 | |
| 3v1y | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.601 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.599 | |
| 1dc6 | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.597 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.595 | |
| 4boy | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.593 | |
| 1jn0 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.589 | |
| 3b20 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.589 | |
| 4lsm | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.583 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.580 | |
| 4dbv | NDP | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.579 | |
| 3k2b | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.572 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.571 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.569 | |
| 1rm3 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.569 | |
| 4z0h | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic | 1.2.1.12 | 0.567 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.565 | |
| 3cps | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.564 | |
| 3e5r | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.564 | |
| 1gad | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.563 | |
| 3zcx | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.562 | |
| 4p8r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.559 | |
| 3gnq | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.555 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.553 | |
| 3cif | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.552 | |
| 1ihx | SND | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.551 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.551 | |
| 3dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.550 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.542 | |
| 1ml3 | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.540 | |
| 1znq | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.540 | |
| 2dbv | NDP | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.540 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.539 | |
| 2pkr | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.538 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.536 | |
| 1a7k | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.534 | |
| 1vc2 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.531 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.530 | |
| 1szj | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.530 | |
| 4o63 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.530 | |
| 3lvf | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.529 | |
| 1qxs | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.525 | |
| 2b4r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.525 | |
| 3dmt | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.523 | |
| 3l0d | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.522 | |
| 3l4s | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.516 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.510 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.509 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.499 | |
| 2vyn | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.496 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.489 | |
| 1ihy | APR | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.487 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.487 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.482 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.482 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.479 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.478 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.477 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.477 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.476 | |
| 2vyv | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.475 | |
| 3gob | HXX | DdmC | / | 0.475 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.475 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.475 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.474 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.473 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.472 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.470 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.470 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.470 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.469 | |
| 2e07 | SAH | Diphthine synthase | / | 0.468 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.467 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.467 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.467 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.467 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.467 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.466 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.466 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.466 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.465 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.465 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.464 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.464 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.463 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.463 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.463 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.463 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.463 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.462 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.462 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.462 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.462 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.461 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.461 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.461 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.461 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.461 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.461 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.461 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.461 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.460 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.460 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.460 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.459 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.459 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.459 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.459 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.459 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.459 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.458 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.458 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.458 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4jlo | ADP | Adenylate kinase | / | 0.457 | |
| 1c70 | L75 | Protease | / | 0.456 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.456 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.456 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.456 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.456 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.456 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.456 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.456 | |
| 5a3c | NAD | SIR2 family protein | / | 0.456 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1h48 | CDI | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.455 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.455 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.455 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.455 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.455 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.455 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.455 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.454 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.454 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.454 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.454 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.454 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.454 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.453 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.453 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.453 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.452 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1kvt | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.452 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2ejz | SAH | Diphthine synthase | / | 0.452 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.452 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.452 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.452 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.452 | |
| 1gae | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.451 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.451 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 2dxw | SAH | Diphthine synthase | / | 0.451 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.451 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.450 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2e08 | SAH | Diphthine synthase | / | 0.450 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.450 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.450 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.450 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.450 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.450 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.449 | |
| 2egb | SAH | Diphthine synthase | / | 0.449 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.449 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.449 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.448 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.448 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.447 | |
| 2ejj | SAH | Diphthine synthase | / | 0.447 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.447 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.447 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.447 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.447 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.447 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.447 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.446 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.446 | |
| 4jld | ADP | Adenylate kinase | / | 0.446 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.446 | |
| 4u7w | NDP | MxaA | / | 0.446 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.446 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.446 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.445 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.445 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.445 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3qrs | NK8 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.445 | |
| 3uzp | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.445 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.445 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.445 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.445 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.444 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2vzz | SCA | Putative succinyl-CoA transferase Rv0802c | 2.8.3 | 0.444 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2y3s | TIR | TamL | / | 0.444 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.444 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.444 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.444 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.444 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.443 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.443 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.443 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.443 | |
| 4j49 | NAI | Uncharacterized protein | / | 0.443 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.443 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.443 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1mbt | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.442 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1qmf | KEF | Penicillin-binding protein 2x | / | 0.442 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.442 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.442 | |
| 2itv | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 2oby | NAP | Quinone oxidoreductase PIG3 | 1 | 0.442 | |
| 2od7 | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.442 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.442 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.442 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.442 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.442 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.442 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.442 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.442 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 5a3b | APR | SIR2 family protein | / | 0.442 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.441 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3vfb | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.441 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.440 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.440 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.440 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 2jd0 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 | |
| 2nnk | ROC | Protease | / | 0.440 | |
| 2owf | SAH | Diphthine synthase | / | 0.440 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2y3r | TIR | TamL | / | 0.440 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.440 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3h8b | NSY | Cathepsin L1 | 3.4.22.15 | 0.440 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.440 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.440 | |
| 3s8c | CDP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.440 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.440 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.440 | |
| 3zuy | TCH | Transporter | / | 0.440 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.440 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |