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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cmfF11Acetylcholinesterase3.1.1.7

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2cmfF11Acetylcholinesterase3.1.1.71.000
1ut6A8NAcetylcholinesterase3.1.1.70.569
1e66HUXAcetylcholinesterase3.1.1.70.529
1zgbA1EAcetylcholinesterase3.1.1.70.514
2ckmAA7Acetylcholinesterase3.1.1.70.496
1votHUPAcetylcholinesterase3.1.1.70.490
2j3qTFLAcetylcholinesterase3.1.1.70.490
1odcA8BAcetylcholinesterase3.1.1.70.480
1zgcA2EAcetylcholinesterase3.1.1.70.480
2xupTZ5Acetylcholinesterase3.1.1.70.475
2xi4AFTAcetylcholinesterase3.1.1.70.470
4ey6GNTAcetylcholinesterase3.1.1.70.468
2w6cBM4Acetylcholinesterase3.1.1.70.466
1qtiGNTAcetylcholinesterase3.1.1.70.464
2xuqTZ4Acetylcholinesterase3.1.1.70.463
1u65CP0Acetylcholinesterase3.1.1.70.462
1q84TZ4Acetylcholinesterase3.1.1.70.461
1h22E10Acetylcholinesterase3.1.1.70.459
1w4lGL8Acetylcholinesterase3.1.1.70.459
1gpnHUBAcetylcholinesterase3.1.1.70.458
4m0f1YKAcetylcholinesterase3.1.1.70.455
1eveE20Acetylcholinesterase3.1.1.70.454
2xuiTZ5Acetylcholinesterase3.1.1.70.454
1w6rGNTAcetylcholinesterase3.1.1.70.450
2whqHI6Acetylcholinesterase3.1.1.70.450
2xukTZ5Acetylcholinesterase3.1.1.70.449