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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cl6CAGGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2cl6CAGGTPase HRas/1.000
1uadGNPRas-related protein Ral-A/0.520
4nyiGNPGTPase HRas/0.505
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.492
3v4fGNPGTPase HRas/0.488
3tsoGNPRas-related protein Rab-25/0.487
4dsuGDPGTPase KRas/0.476
3lbnGNPGTPase HRas/0.472
4nyjGNPGTPase HRas/0.460
3tgpGNPGTPase HRas/0.458
3oivGNPGTPase HRas/0.455
4dxaGSPRas-related protein Rap-1b/0.455
4xvrGNPGTPase HRas/0.455
5c46GSPRas-related protein Rab-11A/0.455
3oiuGNPGTPase HRas/0.454
3qbtGNPRas-related protein Rab-8A/0.454
3i3sGNPGTPase HRas/0.448
1zc4GNPRas-related protein Ral-A/0.446
1kmqGNPTransforming protein RhoA/0.445
1lfdGNPGTPase HRas/0.443
3rs5GNPGTPase HRas/0.443
3kucGDPRas-related protein Rap-1A/0.441