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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cjmATPCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2cjmATPCyclin-dependent kinase 22.7.11.221.000
3my5RFZCyclin-dependent kinase 22.7.11.220.541
4bcmT7ZCyclin-dependent kinase 22.7.11.220.527
1qmzATPCyclin-dependent kinase 22.7.11.220.517
4eooATPCyclin-dependent kinase 22.7.11.220.513
2uzbC75Cyclin-dependent kinase 22.7.11.220.489
4ii5ADPCyclin-dependent kinase 22.7.11.220.485
1jstATPCyclin-dependent kinase 22.7.11.220.471
2vu3LZECyclin-dependent kinase 22.7.11.220.449
3i60E86Mitogen-activated protein kinase 12.7.11.240.444
1ig1ANPDeath-associated protein kinase 12.7.11.10.443
3gu7ADPDeath-associated protein kinase 12.7.11.10.441
4ix5ANPUncharacterized protein/0.441