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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.11.000
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.563
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.560
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.553
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.552
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.548
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.533
5av2KMPDeath-associated protein kinase 12.7.11.10.516
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.515
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.511
1jklANPDeath-associated protein kinase 12.7.11.10.501
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.500
3bqr4RBDeath-associated protein kinase 3/0.498
4ysjADPCalmodulin-like domain protein kinase/0.498
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.496
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.495
5av3KMPDeath-associated protein kinase 12.7.11.10.492
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.491
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.491
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2ckeIQUDeath-associated protein kinase 2/0.484
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.481
3c4xATPRhodopsin kinase/0.480
4l9i8PRRhodopsin kinase/0.478
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.477
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.476
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.475
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.473
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.473
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.472
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.472
1yvj4STTyrosine-protein kinase JAK32.7.10.20.470
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.469
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.468
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.467
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.467
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.466
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.465
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.465
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.465
2j0lANPFocal adhesion kinase 12.7.10.20.464
2hog710Serine/threonine-protein kinase Chk12.7.11.10.462
2yaaATPDeath-associated protein kinase 2/0.462
3my5RFZCyclin-dependent kinase 22.7.11.220.462
4aqc88ATyrosine-protein kinase JAK2/0.462
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.462
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.461
4qnyANPMitogen activated protein kinase, putative/0.461
1jkkANPDeath-associated protein kinase 12.7.11.10.460
3gu7ADPDeath-associated protein kinase 12.7.11.10.460
4hvi19STyrosine-protein kinase JAK32.7.10.20.460
2uzbC75Cyclin-dependent kinase 22.7.11.220.459
5cvfATPCasein kinase II subunit alpha2.7.11.10.459
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.457
4bcmT7ZCyclin-dependent kinase 22.7.11.220.456
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.455
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.455
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.453
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.452
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
3i60E86Mitogen-activated protein kinase 12.7.11.240.449
3zewSTUEphrin type-B receptor 42.7.10.10.449
4jia1K3Tyrosine-protein kinase JAK2/0.449
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.449
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.448
3lltANPProtein serine/threonine kinase-1/0.448
4bbfO19Tyrosine-protein kinase JAK2/0.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
4e6d0NUTyrosine-protein kinase JAK2/0.447
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3gu83GUDeath-associated protein kinase 12.7.11.10.446
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.445
2vu3LZECyclin-dependent kinase 22.7.11.220.444
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3eb0DRKUncharacterized protein/0.444
4j99ACPFibroblast growth factor receptor 2/0.444
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.443
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4i5cC5ITyrosine-protein kinase JAK1/0.443
4o0wADNAurora kinase A2.7.11.10.443
4e4n0NLTyrosine-protein kinase JAK1/0.442
4ehzJAKTyrosine-protein kinase JAK1/0.442
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.442
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.441
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.441
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.441
4hge15VTyrosine-protein kinase JAK2/0.441
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2pmoHMDProtein kinase 7/0.440
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.440