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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.569
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.537
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.531
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.530
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.468
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.461
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.461
4j56FADThioredoxin reductase 21.8.1.90.461
1gerFADGlutathione reductase1.8.1.70.456
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.456
2v6oFADThioredoxin glutathione reductase/0.451
3grsFADGlutathione reductase, mitochondrial1.8.1.70.450
1greFADGlutathione reductase, mitochondrial1.8.1.70.448
1grhFADGlutathione reductase, mitochondrial1.8.1.70.448
1grgFADGlutathione reductase, mitochondrial1.8.1.70.447
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.447
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.443
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.440