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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c6eHPMAurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c6eHPMAurora kinase A2.7.11.11.000
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.496
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.494
4c3pACPAurora kinase A2.7.11.10.489
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.481
4o0uADNAurora kinase A2.7.11.10.474
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.467
2wqeADPAurora kinase A2.7.11.10.464
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.461
3ztxZTXAurora kinase B-A2.7.11.10.456
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.452
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.446
5l8lADPAurora kinase A2.7.11.10.446
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
2vrx447Aurora kinase B-A2.7.11.10.441
4jbpYPHAurora kinase A2.7.11.10.441
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.440
4eym0RXMitogen-activated protein kinase 132.7.11.240.440
4nka2K7Fibroblast growth factor receptor 1/0.440