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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c0tL3GTyrosine-protein kinase HCK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c0tL3GTyrosine-protein kinase HCK2.7.10.21.000
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.707
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.569
3vs1VSATyrosine-protein kinase HCK2.7.10.20.525
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.520
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.493
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.483
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.472
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.464
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.461
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3vryB43Tyrosine-protein kinase HCK2.7.10.20.449
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.448
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.446
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.443
3w2rW2REpidermal growth factor receptor2.7.10.10.443
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.442