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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bfyH1NAurora kinase B-A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2bfyH1NAurora kinase B-A2.7.11.11.000
2vgoAD5Aurora kinase B-A2.7.11.10.546
2vgpAD6Aurora kinase B-A2.7.11.10.522
4fob0USALK tyrosine kinase receptor2.7.10.10.507
2w1fL0FAurora kinase A2.7.11.10.499
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.499
2ijmATPFocal adhesion kinase 12.7.10.20.491
2xvdAS6Ephrin type-B receptor 42.7.10.10.490
3ztxZTXAurora kinase B-A2.7.11.10.490
4fod0UVALK tyrosine kinase receptor2.7.10.10.489
2j4z626Aurora kinase A2.7.11.10.488
4o0uADNAurora kinase A2.7.11.10.488
3k5uPFQAurora kinase A2.7.11.10.487
4b99R4LMitogen-activated protein kinase 72.7.11.240.485
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.478
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
5aaaVGHALK tyrosine kinase receptor2.7.10.10.477
2j0lANPFocal adhesion kinase 12.7.10.20.474
2c6eHPMAurora kinase A2.7.11.10.473
4c3pACPAurora kinase A2.7.11.10.473
4y95746Tyrosine-protein kinase/0.473
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
2xp2VGHALK tyrosine kinase receptor2.7.10.10.472
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4foc0UUALK tyrosine kinase receptor2.7.10.10.471
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.471
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.470
4cd0AWJALK tyrosine kinase receptor2.7.10.10.470
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.470
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.469
3pxkPXKFocal adhesion kinase 12.7.10.20.468
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.467
4anqVGHALK tyrosine kinase receptor2.7.10.10.465
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.464
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.464
2vrx447Aurora kinase B-A2.7.11.10.464
2vwu7X1Ephrin type-B receptor 42.7.10.10.464
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.464
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.463
2itqITQEpidermal growth factor receptor2.7.10.10.463
2j0m4STFocal adhesion kinase 12.7.10.20.463
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4ix6ADPUncharacterized protein/0.462
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.461
3ttjJBIMitogen-activated protein kinase 102.7.11.240.461
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.461
3ttiKBIMitogen-activated protein kinase 102.7.11.240.460
3zewSTUEphrin type-B receptor 42.7.10.10.460
4ansVGHALK tyrosine kinase receptor2.7.10.10.460
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.460
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2x6dX6DAurora kinase A2.7.11.10.459
5aacVGHALK tyrosine kinase receptor2.7.10.10.458
5e8wSTUTGF-beta receptor type-12.7.11.300.458
1bygSTUTyrosine-protein kinase CSK/0.457
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.457
2wqeADPAurora kinase A2.7.11.10.457
4k8aK8AFocal adhesion kinase 12.7.10.20.457
4y93746Tyrosine-protein kinase/0.457
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2etm7PYFocal adhesion kinase 12.7.10.20.455
2yfxVGHALK tyrosine kinase receptor2.7.10.10.455
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.455
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.455
4jboWPHAurora kinase A2.7.11.10.455
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.455
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.455
1i44ACPInsulin receptor2.7.10.10.454
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.454
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.454
4c02TAKActivin receptor type-12.7.11.300.454
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.453
2qo9ANPEphrin type-A receptor 32.7.10.10.453
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4bb432WEphrin type-B receptor 42.7.10.10.453
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.453
4qo9627Serine/threonine-protein kinase 242.7.11.10.453
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4gk3L87Ephrin type-A receptor 32.7.10.10.452
5l8lADPAurora kinase A2.7.11.10.452
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.451
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.451
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.451
4qmzB49Serine/threonine-protein kinase 242.7.11.10.451
5aabVGHALK tyrosine kinase receptor2.7.10.10.451
2w1eL0EAurora kinase A2.7.11.10.450
2x9fX9FEphrin type-B receptor 42.7.10.10.450
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.450
4b8mVX6Aurora kinase B-A2.7.11.10.450
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.450
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.449
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.449
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.449
2xb7GUIALK tyrosine kinase receptor2.7.10.10.449
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.449
1pmn984Mitogen-activated protein kinase 102.7.11.240.448
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.448
3w16P9JAurora kinase A2.7.11.10.448
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.448
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.447
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.447
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.447
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
4g1wG1WMitogen-activated protein kinase 82.7.11.240.447
4lopSB4Mitogen-activated protein kinase 14/0.447
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4zohFADPutative oxidoreductase FAD-binding subunit/0.447
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.446
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.446
4jajXU1Aurora kinase A2.7.11.10.446
3a7hATPSerine/threonine-protein kinase 242.7.11.10.445
3vquO22Dual specificity protein kinase TTK2.7.12.10.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.445
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
3e5aVX6Aurora kinase A2.7.11.10.444
3t8oATPRhodopsin kinase/0.444
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.444
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.444
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.443
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.443
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.443
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.443
4eevL1XHepatocyte growth factor receptor2.7.10.10.443
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4jbqVX6Aurora kinase A2.7.11.10.443
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.443
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.442
3a62STURibosomal protein S6 kinase beta-12.7.11.10.442
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.442
4ccbOFGALK tyrosine kinase receptor2.7.10.10.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.442
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.441
3slkNDPPolyketide synthase extender module 2/0.441
4c4f7CEDual specificity protein kinase TTK2.7.12.10.441
4i4e1BQFocal adhesion kinase 12.7.10.20.441
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.440
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440
3linE13Protease/0.440
4b0gVEKAurora kinase A2.7.11.10.440
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.440
4f650S9Fibroblast growth factor receptor 1/0.440
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.440
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.440
5dr9SKEAurora kinase A2.7.11.10.440