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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bfmTOPPteridine reductase 11.5.1.33

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2bfmTOPPteridine reductase 11.5.1.331.000
2bfpH4BPteridine reductase 11.5.1.330.573
2bf7HBIPteridine reductase 11.5.1.330.571
1e92HBIPteridine reductase 11.5.1.330.565
3h4vDVPPteridine reductase 11.5.1.330.554
1p33MTXPteridine reductase 11.5.1.330.491
2bfaCB3Pteridine reductase 11.5.1.330.482
2qhxFE1Pteridine reductase 11.5.1.330.473
1mxfMTXPutative pteridine reductase 2/0.459
2vz0D64Pteridine reductase/0.457
3bmnAX3Pteridine reductase/0.455
3jq8DX3Pteridine reductase, putative/0.444
3h4vNAPPteridine reductase 11.5.1.330.440