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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b9jADPMitogen-activated protein kinase FUS32.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2b9jADPMitogen-activated protein kinase FUS32.7.11.241.000
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.668
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.574
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.522
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.465
2w17I19Cyclin-dependent kinase 22.7.11.220.462
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.462
1fvv107Cyclin-dependent kinase 22.7.11.220.456
1qmzATPCyclin-dependent kinase 22.7.11.220.455
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
3ezvEZVCyclin-dependent kinase 22.7.11.220.452
4xlvACPInsulin receptor2.7.10.10.452
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.451
1jstATPCyclin-dependent kinase 22.7.11.220.448
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
1g5sI17Cyclin-dependent kinase 22.7.11.220.445
3zh8C58Protein kinase C iota type2.7.11.130.444
1pmn984Mitogen-activated protein kinase 102.7.11.240.442
1ig1ANPDeath-associated protein kinase 12.7.11.10.441
3gu83GUDeath-associated protein kinase 12.7.11.10.441
5dnrATPAurora kinase A2.7.11.10.441
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440