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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b9fADPMitogen-activated protein kinase FUS32.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2b9fADPMitogen-activated protein kinase FUS32.7.11.241.000
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.657
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.645
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.531
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.512
1tvoFRZMitogen-activated protein kinase 12.7.11.240.510
2y9qANPMitogen-activated protein kinase 12.7.11.240.509
1qmzATPCyclin-dependent kinase 22.7.11.220.507
3i60E86Mitogen-activated protein kinase 12.7.11.240.504
4fv6E57Mitogen-activated protein kinase 12.7.11.240.503
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.497
1jstATPCyclin-dependent kinase 22.7.11.220.496
4ii5ADPCyclin-dependent kinase 22.7.11.220.496
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.495
4fv9E71Mitogen-activated protein kinase 12.7.11.240.495
4fmqANPMitogen-activated protein kinase 12.7.11.240.493
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.492
4s33ANPMitogen-activated protein kinase 12.7.11.240.491
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.491
4eomATPCyclin-dependent kinase 22.7.11.220.490
3zh8C58Protein kinase C iota type2.7.11.130.489
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.487
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.486
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.484
4h3qANPMitogen-activated protein kinase 12.7.11.240.484
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.482
2hog710Serine/threonine-protein kinase Chk12.7.11.10.479
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.479
4xlvACPInsulin receptor2.7.10.10.478
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4eooATPCyclin-dependent kinase 22.7.11.220.475
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.474
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.474
4i3zADPCyclin-dependent kinase 22.7.11.220.474
4k33ACPFibroblast growth factor receptor 32.7.10.10.474
1b39ATPCyclin-dependent kinase 22.7.11.220.473
4oauADP2-5A-dependent ribonuclease3.1.260.473
3bu5ATPInsulin receptor2.7.10.10.471
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.470
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.470
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.469
2pmlANPUncharacterized protein/0.468
3c4zADPRhodopsin kinase/0.468
4riyADPEpidermal growth factor receptor2.7.10.10.467
5e92ANPTGF-beta receptor type-22.7.11.300.467
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.466
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2w17I19Cyclin-dependent kinase 22.7.11.220.465
4nj32KDCyclin-dependent kinase 22.7.11.220.465
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.464
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.464
2qoqANPEphrin type-A receptor 32.7.10.10.463
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.461
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.461
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.460
3c50ADPRhodopsin kinase/0.460
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.460
4xj3GTPCyclic GMP-AMP synthase/0.460
4ysjADPCalmodulin-like domain protein kinase/0.460
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.459
3vs3VSETyrosine-protein kinase HCK2.7.10.20.459
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.459
4s32ANPMitogen-activated protein kinase 12.7.11.240.459
5dnrATPAurora kinase A2.7.11.10.459
1hckATPCyclin-dependent kinase 22.7.11.220.458
1nzdUPGDNA beta-glucosyltransferase/0.458
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.458
3ezrEZRCyclin-dependent kinase 22.7.11.220.458
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.457
1x8b824Wee1-like protein kinase2.7.10.20.457
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.457
4jrnANPRhoptry kinase family protein/0.457
1b38ATPCyclin-dependent kinase 22.7.11.220.456
2ojj82AMitogen-activated protein kinase 12.7.11.240.456
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.456
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.456
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.455
3c4wATPRhodopsin kinase/0.455
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.455
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.455
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.454
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.454
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.453
3sheI85MAP kinase-activated protein kinase 32.7.11.10.453
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.453
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.453
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.452
4jr7GNPCasein kinase II subunit alpha2.7.11.10.452
1e9hINRCyclin-dependent kinase 22.7.11.220.451
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.451
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.451
1g5sI17Cyclin-dependent kinase 22.7.11.220.450
1i44ACPInsulin receptor2.7.10.10.450
1u54ACPActivated CDC42 kinase 1/0.450
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.450
3tnwF18Cyclin-dependent kinase 22.7.11.220.450
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4fkg4CKCyclin-dependent kinase 22.7.11.220.450
4ivb1J5Tyrosine-protein kinase JAK1/0.450
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.449
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.449
3iggEFQCyclin-dependent kinase 22.7.11.220.449
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.449
4utdACPAurora kinase A2.7.11.10.449
1finATPCyclin-dependent kinase 22.7.11.220.448
1j39UPGDNA beta-glucosyltransferase/0.448
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.448
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.448
2vv9IM9Cyclin-dependent kinase 22.7.11.220.448
3nynSGVG protein-coupled receptor kinase 62.7.11.160.448
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3lfqA28Cyclin-dependent kinase 22.7.11.220.447
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.447
4s34ANPMitogen-activated protein kinase 12.7.11.240.447
3w16P9JAurora kinase A2.7.11.10.446
3ztxZTXAurora kinase B-A2.7.11.10.446
4qmlANPSerine/threonine-protein kinase 242.7.11.10.446
2btrU73Cyclin-dependent kinase 22.7.11.220.445
2vtqLZACyclin-dependent kinase 22.7.11.220.445
3nux3NVCyclin-dependent kinase 62.7.11.220.445
4e4l0NHTyrosine-protein kinase JAK1/0.445
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.445
4lyn1YGCyclin-dependent kinase 22.7.11.220.445
5drdATPAurora kinase A2.7.11.10.445
1e1xNW1Cyclin-dependent kinase 22.7.11.220.444
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.444
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.444
2henADPEphrin type-B receptor 22.7.10.10.444
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.444
4btjATPTau-tubulin kinase 12.7.11.10.444
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.444
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.443
3nszANPCasein kinase II subunit alpha2.7.11.10.443
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.443
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.443
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.443
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.443
2xmyCDKCyclin-dependent kinase 22.7.11.220.442
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.442
3w551FMMitogen-activated protein kinase 12.7.11.240.442
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4ek816KCyclin-dependent kinase 22.7.11.220.442
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.442
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.442
1ykr628Cyclin-dependent kinase 22.7.11.220.441
2pywADPMethylthioribose kinase2.7.1.1000.441
2wotZZGTGF-beta receptor type-12.7.11.300.441
3at4CCKCasein kinase II subunit alpha2.7.11.10.441
4bgh3I6Cyclin-dependent kinase 22.7.11.220.441
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4ji91M3Tyrosine-protein kinase JAK2/0.441
4o0uADNAurora kinase A2.7.11.10.441
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.440
1pxoCK7Cyclin-dependent kinase 22.7.11.220.440
2np8CC3Aurora kinase A2.7.11.10.440
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.440
4o1pANPRibonuclease L/0.440