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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b69NADUDP-glucuronic acid decarboxylase 14.1.1.35

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2b69NADUDP-glucuronic acid decarboxylase 14.1.1.351.000
1wvgCXYCDP-glucose 4,6-dehydratase4.2.1.450.480
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.472
1kvrNADUDP-glucose 4-epimerase5.1.3.20.471
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.468
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.467
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.461
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.460
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.456
2ydxSTLMethionine adenosyltransferase 2 subunit beta/0.455
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.455
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.454
2givACOHistone acetyltransferase KAT8/0.452
1vfrFMNMajor NAD(P)H-flavin oxidoreductase1.6.990.440