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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b55D31Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2b55D31Cyclin-dependent kinase 22.7.11.221.000
1v1k3FPCyclin-dependent kinase 22.7.11.220.690
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.646
2a0cCK9Cyclin-dependent kinase 22.7.11.220.634
1w8cN69Cyclin-dependent kinase 22.7.11.220.624
2c6o4SPCyclin-dependent kinase 22.7.11.220.615
1g5sI17Cyclin-dependent kinase 22.7.11.220.600
3rjc06ZCyclin-dependent kinase 22.7.11.220.590
1oitHDTCyclin-dependent kinase 22.7.11.220.589
3sqq99ZCyclin-dependent kinase 22.7.11.220.588
1urwI1PCyclin-dependent kinase 22.7.11.220.587
3ig7EFPCyclin-dependent kinase 22.7.11.220.582
3rni21ZCyclin-dependent kinase 22.7.11.220.580
4fkj11KCyclin-dependent kinase 22.7.11.220.580
1oiqHDUCyclin-dependent kinase 22.7.11.220.578
1p2a5BNCyclin-dependent kinase 22.7.11.220.575
1h1r6CPCyclin-dependent kinase 22.7.11.220.574
1vyzN5BCyclin-dependent kinase 22.7.11.220.572
3ddpRC8Cyclin-dependent kinase 22.7.11.220.572
1gih1PUCyclin-dependent kinase 22.7.11.220.571
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.571
1r78FMDCyclin-dependent kinase 22.7.11.220.570
3rm618ZCyclin-dependent kinase 22.7.11.220.570
1ke6LS2Cyclin-dependent kinase 22.7.11.220.566
3rk507ZCyclin-dependent kinase 22.7.11.220.566
3rk909ZCyclin-dependent kinase 22.7.11.220.566
1w0xOLOCyclin-dependent kinase 22.7.11.220.564
3qtzX42Cyclin-dependent kinase 22.7.11.220.564
1di8DTQCyclin-dependent kinase 22.7.11.220.563
3lfsA07Cyclin-dependent kinase 22.7.11.220.562
3r9dX6BCyclin-dependent kinase 22.7.11.220.562
1h1pCMGCyclin-dependent kinase 22.7.11.220.561
3r8lZ30Cyclin-dependent kinase 22.7.11.220.561
1oguST8Cyclin-dependent kinase 22.7.11.220.560
3ral04ZCyclin-dependent kinase 22.7.11.220.559
3ddqRRCCyclin-dependent kinase 22.7.11.220.558
2iw94SPCyclin-dependent kinase 22.7.11.220.555
3r1yX76Cyclin-dependent kinase 22.7.11.220.554
4fki09KCyclin-dependent kinase 22.7.11.220.554
1ke9LS5Cyclin-dependent kinase 22.7.11.220.553
2r3lSCWCyclin-dependent kinase 22.7.11.220.553
3qqkX02Cyclin-dependent kinase 22.7.11.220.553
3r7iX9ICyclin-dependent kinase 22.7.11.220.553
2btsU32Cyclin-dependent kinase 22.7.11.220.552
3qxoX65Cyclin-dependent kinase 22.7.11.220.552
3rpv26ZCyclin-dependent kinase 22.7.11.220.551
2w06FRVCyclin-dependent kinase 22.7.11.220.550
3rmf20ZCyclin-dependent kinase 22.7.11.220.547
4ek610KCyclin-dependent kinase 22.7.11.220.547
3qtrX36Cyclin-dependent kinase 22.7.11.220.546
3s2pPMUCyclin-dependent kinase 22.7.11.220.546
4eor4SPCyclin-dependent kinase 22.7.11.220.546
1vyw292Cyclin-dependent kinase 22.7.11.220.545
3r7vZ02Cyclin-dependent kinase 22.7.11.220.545
3roy22ZCyclin-dependent kinase 22.7.11.220.545
1pxoCK7Cyclin-dependent kinase 22.7.11.220.544
3qzgX67Cyclin-dependent kinase 22.7.11.220.544
4bcpT3CCyclin-dependent kinase 22.7.11.220.544
4bcnT9NCyclin-dependent kinase 22.7.11.220.543
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.542
3dogNNNCyclin-dependent kinase 22.7.11.220.542
3qu0X40Cyclin-dependent kinase 22.7.11.220.542
3rpo24ZCyclin-dependent kinase 22.7.11.220.542
4ez30S0Cyclin-dependent kinase 22.7.11.220.542
3r9hZ67Cyclin-dependent kinase 22.7.11.220.541
3s0o50ZCyclin-dependent kinase 22.7.11.220.541
3sw418KCyclin-dependent kinase 22.7.11.220.541
1pxmCK5Cyclin-dependent kinase 22.7.11.220.540
1oi9N20Cyclin-dependent kinase 22.7.11.220.539
1oiuN76Cyclin-dependent kinase 22.7.11.220.538
3rak03ZCyclin-dependent kinase 22.7.11.220.538
2vtqLZACyclin-dependent kinase 22.7.11.220.537
2vtsLZCCyclin-dependent kinase 22.7.11.220.537
1oiyN41Cyclin-dependent kinase 22.7.11.220.535
1pyePM1Cyclin-dependent kinase 22.7.11.220.535
3rk708ZCyclin-dependent kinase 22.7.11.220.535
4fkv61KCyclin-dependent kinase 22.7.11.220.535
2b52D42Cyclin-dependent kinase 22.7.11.220.533
3r1qX75Cyclin-dependent kinase 22.7.11.220.533
3r7uX96Cyclin-dependent kinase 22.7.11.220.533
4acm7YGCyclin-dependent kinase 22.7.11.220.532
4fkw62KCyclin-dependent kinase 22.7.11.220.532
1h1s4SPCyclin-dependent kinase 22.7.11.220.531
2w05FRTCyclin-dependent kinase 22.7.11.220.530
3qtuX44Cyclin-dependent kinase 22.7.11.220.530
3qwjX6ACyclin-dependent kinase 22.7.11.220.530
3r6xX84Cyclin-dependent kinase 22.7.11.220.530
3r7yZ04Cyclin-dependent kinase 22.7.11.220.530
4fkg4CKCyclin-dependent kinase 22.7.11.220.530
4fkpLS5Cyclin-dependent kinase 22.7.11.220.530
4fkr45KCyclin-dependent kinase 22.7.11.220.530
3qwkX62Cyclin-dependent kinase 22.7.11.220.529
4eok4SPCyclin-dependent kinase 22.7.11.220.529
1ke7LS3Cyclin-dependent kinase 22.7.11.220.528
3qzhX69Cyclin-dependent kinase 22.7.11.220.528
4bgh3I6Cyclin-dependent kinase 22.7.11.220.528
3uli1N3Cyclin-dependent kinase 22.7.11.220.527
3r1sX73Cyclin-dependent kinase 22.7.11.220.526
4fkq42KCyclin-dependent kinase 22.7.11.220.526
1ckpPVBCyclin-dependent kinase 22.7.11.220.525
2btrU73Cyclin-dependent kinase 22.7.11.220.525
2r64740Cyclin-dependent kinase 22.7.11.220.525
3rkb12ZCyclin-dependent kinase 22.7.11.220.525
4bcmT7ZCyclin-dependent kinase 22.7.11.220.525
1gij2PUCyclin-dependent kinase 22.7.11.220.524
3ezrEZRCyclin-dependent kinase 22.7.11.220.524
3qqlX03Cyclin-dependent kinase 22.7.11.220.524
2duv371Cyclin-dependent kinase 22.7.11.220.523
4bcoT6QCyclin-dependent kinase 22.7.11.220.523
1gii1PUCyclin-dependent kinase 22.7.11.220.522
1h0w207Cyclin-dependent kinase 22.7.11.220.522
2iw84SPCyclin-dependent kinase 22.7.11.220.521
3qtwX3ACyclin-dependent kinase 22.7.11.220.521
3r8vZ62Cyclin-dependent kinase 22.7.11.220.521
3rm719ZCyclin-dependent kinase 22.7.11.220.521
2c4g514Cyclin-dependent kinase 22.7.11.220.520
3r71X86Cyclin-dependent kinase 22.7.11.220.520
3r73X87Cyclin-dependent kinase 22.7.11.220.520
3unk0BYCyclin-dependent kinase 22.7.11.220.520
1e9hINRCyclin-dependent kinase 22.7.11.220.519
2r3kSCQCyclin-dependent kinase 22.7.11.220.519
3qtxX43Cyclin-dependent kinase 22.7.11.220.519
3qx2X63Cyclin-dependent kinase 22.7.11.220.519
2vthLZ2Cyclin-dependent kinase 22.7.11.220.518
3qruX19Cyclin-dependent kinase 22.7.11.220.518
1qmzATPCyclin-dependent kinase 22.7.11.220.517
4eoi1ROCyclin-dependent kinase 22.7.11.220.517
2i40BLZCyclin-dependent kinase 22.7.11.220.516
2a4lRRCCyclin-dependent kinase 22.7.11.220.515
3ql8X01Cyclin-dependent kinase 22.7.11.220.515
3lfqA28Cyclin-dependent kinase 22.7.11.220.513
3r7eX88Cyclin-dependent kinase 22.7.11.220.513
4eon1ROCyclin-dependent kinase 22.7.11.220.513
1gy3ATPCyclin-dependent kinase 22.7.11.220.512
2bhhRYUCyclin-dependent kinase 22.7.11.220.512
2xnbY8LCyclin-dependent kinase 22.7.11.220.512
3tnwF18Cyclin-dependent kinase 22.7.11.220.512
1b39ATPCyclin-dependent kinase 22.7.11.220.511
3r28XA0Cyclin-dependent kinase 22.7.11.220.510
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.509
3iggEFQCyclin-dependent kinase 22.7.11.220.509
1aq1STUCyclin-dependent kinase 22.7.11.220.508
4lyn1YGCyclin-dependent kinase 22.7.11.220.508
3rahO1ZCyclin-dependent kinase 22.7.11.220.507
1b38ATPCyclin-dependent kinase 22.7.11.220.506
2w1hL0FCyclin-dependent kinase 22.7.11.220.506
4eomATPCyclin-dependent kinase 22.7.11.220.506
3pj8404Cyclin-dependent kinase 22.7.11.220.505
1h1q2A6Cyclin-dependent kinase 22.7.11.220.504
3qziX72Cyclin-dependent kinase 22.7.11.220.504
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.503
4nj32KDCyclin-dependent kinase 22.7.11.220.503
2fvdLIACyclin-dependent kinase 22.7.11.220.502
3lq5SLQCyclin-dependent kinase 92.7.11.220.502
3qrtX14Cyclin-dependent kinase 22.7.11.220.502
3qtqX35Cyclin-dependent kinase 22.7.11.220.502
3r8zZ63Cyclin-dependent kinase 22.7.11.220.502
3unj0BXCyclin-dependent kinase 22.7.11.220.502
4eop1ROCyclin-dependent kinase 22.7.11.220.502
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.501
1ke5LS1Cyclin-dependent kinase 22.7.11.220.500
2wpa889Cyclin-dependent kinase 22.7.11.220.500
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.500
3raiX85Cyclin-dependent kinase 22.7.11.220.500
3ti1B49Cyclin-dependent kinase 22.7.11.220.500
1dm2HMDCyclin-dependent kinase 22.7.11.220.499
1fvt106Cyclin-dependent kinase 22.7.11.220.499
2xmyCDKCyclin-dependent kinase 22.7.11.220.499
3qqfX07Cyclin-dependent kinase 22.7.11.220.499
2c5yMTWCyclin-dependent kinase 22.7.11.220.498
3sw719KCyclin-dependent kinase 22.7.11.220.498
1pkdUCNCyclin-dependent kinase 22.7.11.220.496
3fz1B98Cyclin-dependent kinase 22.7.11.220.496
4eos1ROCyclin-dependent kinase 22.7.11.220.496
2j9mPY8Cyclin-dependent kinase 22.7.11.220.495
2r3o2SCCyclin-dependent kinase 22.7.11.220.495
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.494
2cchATPCyclin-dependent kinase 22.7.11.220.493
4fkt48KCyclin-dependent kinase 22.7.11.220.493
3r8pZ46Cyclin-dependent kinase 22.7.11.220.492
3r9oZ71Cyclin-dependent kinase 22.7.11.220.491
4fx360KCyclin-dependent kinase 22.7.11.220.491
1ke8LS4Cyclin-dependent kinase 22.7.11.220.490
5aniES4Cyclin-dependent kinase 22.7.11.220.490
1e1xNW1Cyclin-dependent kinase 22.7.11.220.488
2x1nX1NCyclin-dependent kinase 22.7.11.220.488
4qmpDKISerine/threonine-protein kinase 242.7.11.10.488
3qqhX0ACyclin-dependent kinase 22.7.11.220.487
4fko20KCyclin-dependent kinase 22.7.11.220.487
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.487
3pxyJWSCyclin-dependent kinase 22.7.11.220.486
4ez50RSCyclin-dependent kinase 62.7.11.220.486
1pxpCK8Cyclin-dependent kinase 22.7.11.220.485
3rpr25ZCyclin-dependent kinase 22.7.11.220.485
3s00Z60Cyclin-dependent kinase 22.7.11.220.485
2uzoC62Cyclin-dependent kinase 22.7.11.220.484
2vu3LZECyclin-dependent kinase 22.7.11.220.484
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.484
3qx4X4BCyclin-dependent kinase 22.7.11.220.484
3wblPDYCyclin-dependent kinase 22.7.11.220.484
4dgo0JWCasein kinase II subunit alpha2.7.11.10.484
4fks46KCyclin-dependent kinase 22.7.11.220.484
2c5nCK8Cyclin-dependent kinase 22.7.11.220.483
4bcqTJFCyclin-dependent kinase 22.7.11.220.483
2r3gSC9Cyclin-dependent kinase 22.7.11.220.482
2uzeC95Cyclin-dependent kinase 22.7.11.220.481
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.480
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.480
2eufLQQCyclin-dependent kinase 62.7.11.220.479
2vttLZDCyclin-dependent kinase 22.7.11.220.479
3bhtMFRCyclin-dependent kinase 22.7.11.220.479
2exmZIPCyclin-dependent kinase 22.7.11.220.478
2r3p3SCCyclin-dependent kinase 22.7.11.220.478
2uzbC75Cyclin-dependent kinase 22.7.11.220.478
1pxkCK3Cyclin-dependent kinase 22.7.11.220.477
2r3r6SCCyclin-dependent kinase 22.7.11.220.477
2uzdC85Cyclin-dependent kinase 22.7.11.220.476
1unlRRCCyclin-dependent-like kinase 52.7.11.10.475
2f2cAP9Cyclin-dependent kinase 62.7.11.220.475
1finATPCyclin-dependent kinase 22.7.11.220.474
4cfnJYMCyclin-dependent kinase 22.7.11.220.473
3ggfGVDSerine/threonine-protein kinase 26/0.472
3rpy27ZCyclin-dependent kinase 22.7.11.220.471
1fvv107Cyclin-dependent kinase 22.7.11.220.470
2c6tDT5Cyclin-dependent kinase 22.7.11.220.470
2r3mSCXCyclin-dependent kinase 22.7.11.220.470
2wotZZGTGF-beta receptor type-12.7.11.300.470
3r8uZ31Cyclin-dependent kinase 22.7.11.220.470
3tiz3TICyclin-dependent kinase 22.7.11.220.470
1xjdSTUProtein kinase C theta type2.7.11.130.469
2pvnP63Casein kinase II subunit alpha2.7.11.10.469
2c6mDT5Cyclin-dependent kinase 22.7.11.220.468
2uzlC94Cyclin-dependent kinase 22.7.11.220.468
3py0SU9Cyclin-dependent kinase 22.7.11.220.468
3r9nZ68Cyclin-dependent kinase 22.7.11.220.468
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2r3fSC8Cyclin-dependent kinase 22.7.11.220.465
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.464
3rzb02ZCyclin-dependent kinase 22.7.11.220.464
1h0vUN4Cyclin-dependent kinase 22.7.11.220.463
2b54D05Cyclin-dependent kinase 22.7.11.220.463
2uznC96Cyclin-dependent kinase 22.7.11.220.463
4eol1ROCyclin-dependent kinase 22.7.11.220.463
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4jqeANPCasein kinase II subunit alpha2.7.11.10.462
4gub0Y4Casein kinase II subunit alpha2.7.11.10.461
2c6lDT4Cyclin-dependent kinase 22.7.11.220.460
2wxvWXVCyclin-dependent kinase 22.7.11.220.460
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.459
2r3iSCFCyclin-dependent kinase 22.7.11.220.458
3sheI85MAP kinase-activated protein kinase 32.7.11.10.458
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.457
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.456
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.456
3be9P04Casein kinase II subunit alpha2.7.11.10.455
3qzfX66Cyclin-dependent kinase 22.7.11.220.455
2c68CT6Cyclin-dependent kinase 22.7.11.220.454
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
1gz8MBPCyclin-dependent kinase 22.7.11.220.452
2wipP49Cyclin-dependent kinase 22.7.11.220.452
3u4uLNHCasein kinase II subunit alpha2.7.11.10.452
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.450
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4dgmAGICasein kinase II subunit alpha2.7.11.10.450
2izsBRQCasein kinase I isoform gamma-32.7.11.10.449
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.449
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.448
2dwbANPAurora kinase A2.7.11.10.448
2wihP48Cyclin-dependent kinase 22.7.11.220.448
3axwTIDCasein kinase II subunit alpha2.7.11.10.448
3lu8IQXSerum albumin/0.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.448
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.447
3zh8C58Protein kinase C iota type2.7.11.130.446
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.446
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.445
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.445
4qmySTUSerine/threonine-protein kinase 242.7.11.10.445
5cu6ATPCasein kinase II subunit alpha2.7.11.10.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1uyuCAMCamphor 5-monooxygenase1.14.15.10.443
2c69CT8Cyclin-dependent kinase 22.7.11.220.443
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.443
3nup3NUCyclin-dependent kinase 62.7.11.220.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.443
4kd11QKCyclin-dependent kinase 22.7.11.220.443
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.443
2b53D23Cyclin-dependent kinase 22.7.11.220.442
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.442
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.442
5dt0SKEAurora kinase A2.7.11.10.442
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.441
2h96893Mitogen-activated protein kinase 82.7.11.240.441
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.441
4g160VMCasein kinase I isoform gamma-32.7.11.10.441
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.440
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.440
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3qtsX46Cyclin-dependent kinase 22.7.11.220.440
3zewSTUEphrin type-B receptor 42.7.10.10.440
4anmWULCasein kinase II subunit alpha2.7.11.10.440
4ek816KCyclin-dependent kinase 22.7.11.220.440
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.440
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.440
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.440
5e8wSTUTGF-beta receptor type-12.7.11.300.440