sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 1.000 | |
| 1m2h | APR | NAD-dependent protein deacylase 1 | / | 0.504 | |
| 1m2g | APR | NAD-dependent protein deacylase 1 | / | 0.480 | |
| 1m2k | APR | NAD-dependent protein deacylase 1 | / | 0.479 | |
| 4iao | APR | NAD-dependent histone deacetylase SIR2 | 3.5.1 | 0.470 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.467 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.464 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 4bvb | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.458 | |
| 1m2j | APR | NAD-dependent protein deacylase 1 | / | 0.457 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.457 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.455 | |
| 1s7g | APR | NAD-dependent protein deacylase 2 | / | 0.455 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.455 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.452 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.450 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.448 | |
| 1yc2 | APR | NAD-dependent protein deacylase 2 | / | 0.448 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.446 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.446 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.445 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.444 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.444 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 2p2x | SAH | Diphthine synthase | / | 0.442 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 5e7o | MGD | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.441 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.441 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.440 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 |