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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ayp43ASerine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ayp43ASerine/threonine-protein kinase Chk12.7.11.11.000
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.615
2hog710Serine/threonine-protein kinase Chk12.7.11.10.595
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.581
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.577
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.568
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.568
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.566
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.560
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.559
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.554
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.554
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.553
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.550
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.550
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.550
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.547
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.545
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.543
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.541
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.541
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.540
1zys199Serine/threonine-protein kinase Chk12.7.11.10.539
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.538
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.537
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.536
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.535
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.534
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.532
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.531
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.529
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.529
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.529
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.527
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.527
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.526
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.525
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.525
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.523
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.523
3a62STURibosomal protein S6 kinase beta-12.7.11.10.521
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.520
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.518
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.517
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.516
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.516
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.513
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.512
1wvxBD4Death-associated protein kinase 12.7.11.10.511
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.511
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.506
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.506
3gu6ADPDeath-associated protein kinase 12.7.11.10.505
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.505
3zh8C58Protein kinase C iota type2.7.11.130.504
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.504
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.503
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.500
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.498
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.496
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.495
1pkdUCNCyclin-dependent kinase 22.7.11.220.495
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.495
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.495
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.494
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.493
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.493
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.492
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.492
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.492
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.491
4hvh19RTyrosine-protein kinase JAK32.7.10.20.491
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.487
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.487
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.487
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.487
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.486
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.486
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.486
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.485
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.485
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.485
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.484
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.484
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.483
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.483
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.482
4nka2K7Fibroblast growth factor receptor 1/0.482
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.481
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.481
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.481
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.481
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.480
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.479
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.479
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.478
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.478
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.477
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.476
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.475
3tnwF18Cyclin-dependent kinase 22.7.11.220.474
3ztxZTXAurora kinase B-A2.7.11.10.474
5auwQUEDeath-associated protein kinase 12.7.11.10.474
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.472
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.472
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.472
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.472
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.472
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1aq1STUCyclin-dependent kinase 22.7.11.220.471
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.471
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.471
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.471
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.471
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.470
3gubGUBDeath-associated protein kinase 12.7.11.10.470
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.469
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.469
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
4c62XWWTyrosine-protein kinase JAK2/0.469
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.469
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.468
4bcqTJFCyclin-dependent kinase 22.7.11.220.468
4hvg19QTyrosine-protein kinase JAK32.7.10.20.468
4j97ACPFibroblast growth factor receptor 2/0.468
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.467
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.467
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.467
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.467
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.466
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.466
3eb0DRKUncharacterized protein/0.466
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.465
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.465
2c4g514Cyclin-dependent kinase 22.7.11.220.464
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.464
4gu94GUFocal adhesion kinase 12.7.10.20.464
5auvAGIDeath-associated protein kinase 12.7.11.10.464
5av4GENDeath-associated protein kinase 12.7.11.10.464
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.463
4fx360KCyclin-dependent kinase 22.7.11.220.463
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.462
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.462
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.462
3w2sW2REpidermal growth factor receptor2.7.10.10.462
2bujSTUSerine/threonine-protein kinase 16/0.461
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.461
3bhy7CPDeath-associated protein kinase 3/0.461
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.461
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.461
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2cchATPCyclin-dependent kinase 22.7.11.220.460
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.460
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.460
5av2KMPDeath-associated protein kinase 12.7.11.10.460
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.459
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.459
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.458
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.458
3emg685Tyrosine-protein kinase SYK2.7.10.20.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.458
4f640S8Fibroblast growth factor receptor 1/0.458
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.458
2x6dX6DAurora kinase A2.7.11.10.457
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.457
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.456
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
3i60E86Mitogen-activated protein kinase 12.7.11.240.456
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.456
5auxKMPDeath-associated protein kinase 12.7.11.10.456
1yvj4STTyrosine-protein kinase JAK32.7.10.20.455
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.455
2z2w770Wee1-like protein kinase2.7.10.20.455
3zewSTUEphrin type-B receptor 42.7.10.10.455
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
5dr9SKEAurora kinase A2.7.11.10.455
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.454
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.454
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.454
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.453
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.453
1e9hINRCyclin-dependent kinase 22.7.11.220.452
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.452
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.452
4y93746Tyrosine-protein kinase/0.452
1finATPCyclin-dependent kinase 22.7.11.220.451
1xjdSTUProtein kinase C theta type2.7.11.130.451
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.450
2csnCKICasein kinase I homolog 12.7.11.10.450
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4hvi19STyrosine-protein kinase JAK32.7.10.20.450
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.450
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.449
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.449
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.449
3sheI85MAP kinase-activated protein kinase 32.7.11.10.449
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.449
5auzGENDeath-associated protein kinase 12.7.11.10.449
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.448
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.448
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2i40BLZCyclin-dependent kinase 22.7.11.220.447
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.447
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.447
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.447
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.447
1fvv107Cyclin-dependent kinase 22.7.11.220.446
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.446
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.446
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.446
4ii5ADPCyclin-dependent kinase 22.7.11.220.446
5aaaVGHALK tyrosine kinase receptor2.7.10.10.446
2vgpAD6Aurora kinase B-A2.7.11.10.445
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.445
3s4qNK0Mitogen-activated protein kinase 14/0.445
4gk3L87Ephrin type-A receptor 32.7.10.10.445
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.444
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.444
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.444
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.444
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.444
4btkDTQTau-tubulin kinase 12.7.11.10.444
4erwSTUCyclin-dependent kinase 22.7.11.220.444
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.444
4i22IREEpidermal growth factor receptor2.7.10.10.444
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.443
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.443
2ckeIQUDeath-associated protein kinase 2/0.443
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.443
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.442
3bqr4RBDeath-associated protein kinase 3/0.442
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.442
4f630S7Fibroblast growth factor receptor 1/0.442
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.441
2vd5BI8Myotonin-protein kinase2.7.11.10.441
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.441
3c4xATPRhodopsin kinase/0.441
3c50ADPRhodopsin kinase/0.441
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.441
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.441
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.441
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.441
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.441
4dce0JFALK tyrosine kinase receptor2.7.10.10.441
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.440
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
2yn8STUEphrin type-B receptor 42.7.10.10.440
3r9dX6BCyclin-dependent kinase 22.7.11.220.440
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.440
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.440