sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2avx | HTF | Regulatory protein SdiA |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2avx | HTF | Regulatory protein SdiA | / | 1.000 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.516 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.490 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.467 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.460 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.459 | |
| 3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.459 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.458 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.457 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.456 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.456 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.455 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.454 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.451 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.450 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.449 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.449 | |
| 3c1o | NAP | Eugenol synthase | / | 0.448 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3qp8 | HL0 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.448 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.446 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.441 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.440 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.440 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.440 |