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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aj8SC3Dipeptidyl peptidase 4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2aj8SC3Dipeptidyl peptidase 4/1.000
4a5sN7FDipeptidyl peptidase 4/0.629
3ccc7ACDipeptidyl peptidase 4/0.618
3opmLUIDipeptidyl peptidase 4/0.615
4g1f0WGDipeptidyl peptidase 4/0.606
3g0gRUMDipeptidyl peptidase 4/0.591
3g0bT22Dipeptidyl peptidase 4/0.562
2rgu356Dipeptidyl peptidase 4/0.547
3g0dXIHDipeptidyl peptidase 4/0.533
3qbjNXZDipeptidyl peptidase 4/0.532
3vjlW94Dipeptidyl peptidase 4/0.532
3ccbB2YDipeptidyl peptidase 4/0.531
3f8sPF2Dipeptidyl peptidase 4/0.515
4rvdSAMD-mycarose 3-C-methyltransferase/0.469
4ffw715Dipeptidyl peptidase 4/0.467
4qnwFMNChanoclavine-I aldehyde reductase easA/0.459
3q9bB3NAcetylpolyamine amidohydrolase/0.455
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.453
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
4q0kGA3Phytohormone-binding protein/0.448
2rqfJH3Hemolymph juvenile hormone binding protein/0.440
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3v0p4GWHisto-blood group ABO system transferase/0.440
4gdcNDPUDP-galactopyranose mutase/0.440