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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2acxANPG protein-coupled receptor kinase 62.7.11.16

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2acxANPG protein-coupled receptor kinase 62.7.11.161.000
3c4wATPRhodopsin kinase/0.563
3t8oATPRhodopsin kinase/0.547
2qo9ANPEphrin type-A receptor 32.7.10.10.543
3c50ADPRhodopsin kinase/0.534
2hog710Serine/threonine-protein kinase Chk12.7.11.10.527
3qc9ADPRhodopsin kinase/0.525
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.519
3c4xATPRhodopsin kinase/0.518
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.517
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.515
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.514
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.511
3c4zADPRhodopsin kinase/0.510
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.506
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.500
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.498
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.497
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.495
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.494
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.493
4wboANWRhodopsin kinase/0.493
3a7jADPSerine/threonine-protein kinase 242.7.11.10.492
4qo9627Serine/threonine-protein kinase 242.7.11.10.492
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.491
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.491
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.485
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.483
3a7hATPSerine/threonine-protein kinase 242.7.11.10.482
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.482
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.481
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.481
2henADPEphrin type-B receptor 22.7.10.10.480
2qoqANPEphrin type-A receptor 32.7.10.10.480
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.480
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.479
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.478
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.477
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.477
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.476
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.476
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.475
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.475
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.474
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.474
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.474
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.473
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.473
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.472
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.472
4qmlANPSerine/threonine-protein kinase 242.7.11.10.472
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.471
3lctADPALK tyrosine kinase receptor2.7.10.10.471
4qms1N1Serine/threonine-protein kinase 242.7.11.10.471
5dt3ATPAurora kinase A2.7.11.10.471
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.470
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.470
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.470
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.469
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.469
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.469
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.469
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.468
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.467
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.466
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3q5iANPProtein kinase, putative/0.466
4gu94GUFocal adhesion kinase 12.7.10.20.466
4k8aK8AFocal adhesion kinase 12.7.10.20.466
4l9i8PRRhodopsin kinase/0.466
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.465
4jrnANPRhoptry kinase family protein/0.465
4qnaX11Serine/threonine-protein kinase 242.7.11.10.465
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.464
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.464
4eomATPCyclin-dependent kinase 22.7.11.220.464
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.464
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.463
4g2fC07Ephrin type-A receptor 32.7.10.10.463
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.462
2qo7ANPEphrin type-A receptor 32.7.10.10.461
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.460
4gk3L87Ephrin type-A receptor 32.7.10.10.460
4k33ACPFibroblast growth factor receptor 32.7.10.10.460
4riyADPEpidermal growth factor receptor2.7.10.10.460
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.459
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.459
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.459
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.459
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.459
2py3ACPFibroblast growth factor receptor 2/0.458
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.458
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
5dn3ATPAurora kinase A2.7.11.10.458
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.457
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.457
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.457
1gy3ATPCyclin-dependent kinase 22.7.11.220.456
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.456
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.456
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.456
4qmzB49Serine/threonine-protein kinase 242.7.11.10.456
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.455
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.455
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.455
5auwQUEDeath-associated protein kinase 12.7.11.10.455
1ol5ADPAurora kinase A2.7.11.10.454
1ol7ADPAurora kinase A2.7.11.10.454
1zrzBI1Protein kinase C iota type2.7.11.130.454
2wxvWXVCyclin-dependent kinase 22.7.11.220.454
4b99R4LMitogen-activated protein kinase 72.7.11.240.454
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.454
2etm7PYFocal adhesion kinase 12.7.10.20.453
2j0lANPFocal adhesion kinase 12.7.10.20.453
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.453
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.453
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.452
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.452
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.452
3dmhSAMProbable ribosomal RNA small subunit methyltransferase/0.452
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.452
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.452
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.452
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.452
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.451
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.451
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
4tuvCPZCytochrome P450 1191.140.451
1u54ACPActivated CDC42 kinase 1/0.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.450
4lopSB4Mitogen-activated protein kinase 14/0.450
4utdACPAurora kinase A2.7.11.10.450
4xlvACPInsulin receptor2.7.10.10.450
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4fob0USALK tyrosine kinase receptor2.7.10.10.449
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.449
5dt4ATPAurora kinase A2.7.11.10.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.448
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.448
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.448
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.448
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.448
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.448
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.448
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.448
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.447
2qocANPEphrin type-A receptor 32.7.10.10.447
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.447
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.446
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.446
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.446
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.446
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.446
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
1ol6ATPAurora kinase A2.7.11.10.445
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.445
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.445
2ittAEEEpidermal growth factor receptor2.7.10.10.445
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.445
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.445
5cvhADPCasein kinase II subunit alpha2.7.11.10.445
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.444
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.444
2pzpACPFibroblast growth factor receptor 2/0.444
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.444
3a62STURibosomal protein S6 kinase beta-12.7.11.10.444
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.444
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.444
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.444
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.444
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.444
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.444
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.443
3my5RFZCyclin-dependent kinase 22.7.11.220.443
4gk2L66Ephrin type-A receptor 32.7.10.10.443
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.443
1csnATPCasein kinase I homolog 12.7.11.10.442
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.442
2izt23DCasein kinase I isoform gamma-32.7.11.10.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.442
2wqeADPAurora kinase A2.7.11.10.442
3gu5ANPDeath-associated protein kinase 12.7.11.10.442
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.442
1ir3ANPInsulin receptor2.7.10.10.441
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.441
2gs7ANPEpidermal growth factor receptor2.7.10.10.441
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.441
2x1nX1NCyclin-dependent kinase 22.7.11.220.441
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.441
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.441
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.440
3bu5ATPInsulin receptor2.7.10.10.440
3igoANPCalmodulin-domain protein kinase 1, putative/0.440
3u9eCOALmo1369 protein/0.440
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.440
3vjoANPEpidermal growth factor receptor2.7.10.10.440
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.440
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.440
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.440