sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2a8h | 4NH | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2a8h | 4NH | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 1.000 | |
| 1zxc | IH6 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.638 | |
| 2i47 | KGY | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.587 | |
| 3le9 | 727 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.577 | |
| 3kme | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.574 | |
| 3kmc | 403 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.571 | |
| 3b92 | 440 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.546 | |
| 2i47 | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.531 | |
| 2w14 | WR2 | Snake venom metalloproteinase BaP1 | 3.4.24 | 0.523 | |
| 3l0v | 724 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.521 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.509 | |
| 3l0t | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.506 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.501 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.499 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.494 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.492 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.490 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.489 | |
| 1atl | 0QI | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.488 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.485 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.485 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.484 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.484 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.482 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.482 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.481 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.480 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.479 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.477 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.477 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.476 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.476 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.475 | |
| 5dp2 | NAP | CurF | / | 0.475 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.474 | |
| 2xuu | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.474 | |
| 5a3c | NAD | SIR2 family protein | / | 0.474 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.473 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.473 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.473 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.472 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.471 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.470 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 2o12 | FMN | Chorismate synthase | / | 0.469 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.469 | |
| 3u9e | COA | Lmo1369 protein | / | 0.469 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.468 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.468 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 3qvi | K95 | HAP protein | / | 0.468 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.467 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.467 | |
| 4qmw | KS1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.467 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.466 | |
| 2w13 | WR2 | Snake venom metalloproteinase BaP1 | 3.4.24 | 0.466 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.466 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.466 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.465 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.465 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 4uoc | NCN | CinA-like protein | / | 0.465 | |
| 4yqf | GDP | Septin-9 | / | 0.465 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.464 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.463 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.463 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.463 | |
| 4xq6 | FMN | Dihydroorotate dehydrogenase (quinone) | / | 0.463 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.462 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.462 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.462 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.462 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.461 | |
| 2qdx | FAD | Ferredoxin--NADP+ reductase | / | 0.461 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.461 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.460 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.460 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.460 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.460 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.460 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.460 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.460 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.460 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.460 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.459 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.459 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.459 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.459 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.459 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.459 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.458 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.458 | |
| 1zz2 | B11 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.458 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 2pxa | SAH | Genome polyprotein | 2.7.7.48 | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.458 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.458 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.458 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.458 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.457 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.457 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.457 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.457 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.457 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.456 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.456 | |
| 3kbz | 2T4 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.456 | |
| 4e2b | FMN | Dehydrogenase | / | 0.456 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.456 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.455 | |
| 1fml | RTL | Retinol dehydratase | / | 0.455 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.455 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.455 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.455 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.455 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.455 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.455 | |
| 4u7w | NDP | MxaA | / | 0.455 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.455 | |
| 1r2j | FAD | FkbI | / | 0.454 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.454 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.454 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.454 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.454 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.454 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.453 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.453 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 3i0a | DBH | Neutrophil gelatinase-associated lipocalin | / | 0.453 | |
| 4ho9 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.453 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.453 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.453 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.453 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.452 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.452 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.452 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.452 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.452 | |
| 2e77 | FMN | Lactate oxidase | / | 0.452 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.452 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.452 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.452 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.452 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.452 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.452 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.451 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.451 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.451 | |
| 1xdp | ATP | Polyphosphate kinase | / | 0.451 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.451 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.451 | |
| 2vtb | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.451 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.451 | |
| 3nf8 | CDQ | Gag-Pol polyprotein | / | 0.451 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.451 | |
| 3w2u | ROU | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.451 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.451 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.451 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.451 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.451 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.450 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.450 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 1rm8 | BAT | Matrix metalloproteinase-16 | 3.4.24 | 0.450 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.450 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.450 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.450 | |
| 4rje | FNR | Lactate oxidase | / | 0.450 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.450 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.449 | |
| 1bwf | ATF | Glycerol kinase | / | 0.449 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.449 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.449 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.449 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.449 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.449 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.449 | |
| 1e2n | RCA | Thymidine kinase | / | 0.448 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.448 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.448 | |
| 1q43 | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.448 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.448 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 3lxp | IZA | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.448 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.448 | |
| 3w1t | WRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.448 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.448 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.448 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.448 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.447 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.447 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.447 | |
| 1skg | VAL_ALA_PHE_ARG_SER | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.447 | |
| 2ab8 | ACP | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 2ejz | SAH | Diphthine synthase | / | 0.447 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.447 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.447 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.447 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.447 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.447 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.447 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 3pch | CHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.447 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4gah | 0ET | Acyl-coenzyme A thioesterase THEM4 | 3.1.2.2 | 0.447 | |
| 4o63 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.447 | |
| 5ebu | FMN | Lactate oxidase | / | 0.447 | |
| 1bmf | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.446 | |
| 1bmf | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.446 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.446 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.446 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.446 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2ddy | MDW | Matrilysin | 3.4.24.23 | 0.446 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.446 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.446 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3k6l | 2BB | Peptide deformylase | 3.5.1.88 | 0.446 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.446 | |
| 3spt | UD1 | Bifunctional protein GlmU | / | 0.446 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.446 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.446 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.446 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.445 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.445 | |
| 2f3m | GTD | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.445 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.445 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.445 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.445 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.445 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.445 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.445 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.445 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 3fd6 | ADP | Selenide, water dikinase 1 | 2.7.9.3 | 0.445 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.445 | |
| 3ggu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3h8b | NSY | Cathepsin L1 | 3.4.22.15 | 0.445 | |
| 3lgp | 50X | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.445 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.445 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.445 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.445 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.445 | |
| 3uf6 | COD | Lmo1369 protein | / | 0.445 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.445 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.445 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.445 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.445 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.445 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.444 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.444 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1uam | SAH | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.444 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.444 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.444 | |
| 2j4d | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.444 | |
| 2r8o | T5X | Transketolase 1 | / | 0.444 | |
| 2srt | INH | Stromelysin-1 | 3.4.24.17 | 0.444 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.444 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.444 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3dt2 | GTP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.444 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.444 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.444 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1m2q | MNX | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.443 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2bi8 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.443 | |
| 2gbl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.443 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.443 | |
| 2qtv | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.443 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.443 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.443 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.443 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.443 | |
| 3w23 | 3RO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.443 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.442 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.442 | |
| 1m8j | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.442 | |
| 1mbt | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.442 | |
| 1oya | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2djx | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.442 | |
| 2nli | FMN | Lactate oxidase | / | 0.442 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.442 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.442 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.442 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.442 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.442 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.442 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.442 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 4g3q | UD1 | Bifunctional protein GlmU | / | 0.442 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.441 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.441 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.441 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.441 | |
| 2ahv | COA | Acetate CoA-transferase YdiF | 2.8.3.8 | 0.441 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.441 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.441 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2zrv | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3b9l | AZZ | Serum albumin | / | 0.441 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.441 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.441 | |
| 4e2d | FMN | Dehydrogenase | / | 0.441 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.441 | |
| 4jic | FMN | GTN Reductase | / | 0.441 | |
| 4pgh | SAM | Caffeic acid O-methyltransferase | / | 0.441 | |
| 4ybr | NAP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.441 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.441 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.440 | |
| 1l9k | SAH | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.440 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1zy8 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.440 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.440 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.440 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.440 | |
| 3cnp | SP7 | Polyamine oxidase FMS1 | / | 0.440 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.440 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.440 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.440 | |
| 3w1r | MRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.440 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4f09 | JAK | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 4g3p | UD1 | Bifunctional protein GlmU | / | 0.440 | |
| 4ix4 | ADP | Uncharacterized protein | / | 0.440 | |
| 4lb2 | DM5 | Serum albumin | / | 0.440 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.440 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.440 |