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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.101.000
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.588
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.577
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.567
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.564
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.564
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.561
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.547
3krfDSTGeranyl diphosphate synthase large subunit/0.524
1rqjRISFarnesyl diphosphate synthase2.5.1.100.514
3rywK9HFarnesyl pyrophosphate synthase, putative/0.509
4nkeIPEFarnesyl pyrophosphate synthase2.5.1.100.505
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.504
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.501
3ez3IPEFarnesyl pyrophosphate synthase, putative/0.500
3krfIPEGeranyl diphosphate synthase large subunit/0.486
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.100.486
3oabDSTGeranyl diphosphate synthase large subunit/0.482
4lfgIPEPutative geranyltranstransferase/0.481
3dyh721Farnesyl pyrophosphate synthase/0.471
3egt722Farnesyl pyrophosphate synthase/0.464
1rqjIPEFarnesyl diphosphate synthase2.5.1.100.463
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.461
4dwb0M7Farnesyl pyrophosphate synthase/0.449