sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1zrd	CMP	cAMP-activated global transcriptional regulator CRP

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1zrd	CMP	cAMP-activated global transcriptional regulator CRP	/	1.000
4ft8	CMP	cAMP-activated global transcriptional regulator CRP	/	0.615
4r8h	SP1	cAMP-activated global transcriptional regulator CRP	/	0.591
4i01	CMP	cAMP-activated global transcriptional regulator CRP	/	0.582
4hzf	CMP	cAMP-activated global transcriptional regulator CRP	/	0.576
3rou	CMP	cAMP-activated global transcriptional regulator CRP	/	0.571
1zrc	CMP	cAMP-activated global transcriptional regulator CRP	/	0.568
2gzw	CMP	cAMP-activated global transcriptional regulator CRP	/	0.568
3ryp	CMP	cAMP-activated global transcriptional regulator CRP	/	0.549
3rpq	CMP	cAMP-activated global transcriptional regulator CRP	/	0.547
1i5z	CMP	cAMP-activated global transcriptional regulator CRP	/	0.536
4i0a	CMP	cAMP-activated global transcriptional regulator CRP	/	0.535
3kcc	CMP	cAMP-activated global transcriptional regulator CRP	/	0.530
4i09	CMP	cAMP-activated global transcriptional regulator CRP	/	0.522
1ruo	CMP	cAMP-activated global transcriptional regulator CRP	/	0.517
3qop	CMP	cAMP-activated global transcriptional regulator CRP	/	0.472
4n9i	PCG	Catabolite expression activator	/	0.446