sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1zrc	CMP	cAMP-activated global transcriptional regulator CRP

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1zrc	CMP	cAMP-activated global transcriptional regulator CRP	/	1.000
4i01	CMP	cAMP-activated global transcriptional regulator CRP	/	0.598
4ft8	CMP	cAMP-activated global transcriptional regulator CRP	/	0.597
2gzw	CMP	cAMP-activated global transcriptional regulator CRP	/	0.575
3rpq	CMP	cAMP-activated global transcriptional regulator CRP	/	0.570
3ryp	CMP	cAMP-activated global transcriptional regulator CRP	/	0.561
4hzf	CMP	cAMP-activated global transcriptional regulator CRP	/	0.558
1i5z	CMP	cAMP-activated global transcriptional regulator CRP	/	0.557
4r8h	SP1	cAMP-activated global transcriptional regulator CRP	/	0.557
3rou	CMP	cAMP-activated global transcriptional regulator CRP	/	0.555
1zrd	CMP	cAMP-activated global transcriptional regulator CRP	/	0.554
3kcc	CMP	cAMP-activated global transcriptional regulator CRP	/	0.550
4i09	CMP	cAMP-activated global transcriptional regulator CRP	/	0.548
4i0a	CMP	cAMP-activated global transcriptional regulator CRP	/	0.535
1ruo	CMP	cAMP-activated global transcriptional regulator CRP	/	0.490
3qop	CMP	cAMP-activated global transcriptional regulator CRP	/	0.467
4n9i	PCG	Catabolite expression activator	/	0.457
3sp6	IL2	Peroxisome proliferator-activated receptor alpha	/	0.451