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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zmtRNOHalohydrin dehalogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
1zmtRNOHalohydrin dehalogenase/1.000
1px0RPNHalohydrin dehalogenase/0.645
1kmsLIHDihydrofolate reductase1.5.1.30.525
1w6jR71Lanosterol synthase5.4.99.70.516
4dch4DCGlucokinase2.7.1.20.509
1kmvLIIDihydrofolate reductase1.5.1.30.508
1ihiIU5Aldo-keto reductase family 1 member C2/0.505
2zhq27UProthrombin3.4.21.50.502
4u140HKMuscarinic acetylcholine receptor M3/0.502
2wgs1AZGlutamine synthetase6.3.1.20.500
1d3dBZTProthrombin3.4.21.50.499
1pd9CO4Dihydrofolate reductase1.5.1.30.499
2qryTPSThiamine-binding periplasmic protein/0.497
2fz8ZSTAldose reductase1.1.1.210.494
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.492
4lwxMU2Ribosome inactivating protein/0.492
4tjy3GNTankyrase-22.4.2.300.491
1hfrMOTDihydrofolate reductase1.5.1.30.490
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.490
2xi4AFTAcetylcholinesterase3.1.1.70.490
3gyf51PDihydrofolate reductase1.5.1.30.490
1jf2CZHObelin/0.489
1nm6L86Prothrombin3.4.21.50.489
1w1wAGSStructural maintenance of chromosomes protein 1/0.488
3biz61EWee1-like protein kinase2.7.10.20.488
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.488
4ixt1H1Halohydrin dehalogenase/0.488
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.487
3gi2GHWDihydrofolate reductase1.5.1.30.487
1drfFOLDihydrofolate reductase1.5.1.30.486
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.486
2xlpNAPPutative flavin-containing monooxygenase/0.486
3r43ID8Aldo-keto reductase family 1 member C3/0.486
3r6iJMSAldo-keto reductase family 1 member C3/0.486
2y0468HBeta-1 adrenergic receptor/0.486
1pd8CO4Dihydrofolate reductase1.5.1.30.485
3nu03TUDihydrofolate reductase1.5.1.30.485
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.485
4jtqFLPAldo-keto reductase family 1 member C2/0.485
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.484
1yplRA8Prothrombin3.4.21.50.483
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.482
1ychFMNNitric oxide reductase10.482
2fzjDH3Dihydrofolate reductase1.5.1.30.482
3t0kDCQSulfide-quinone reductase/0.482
2zgx29UProthrombin3.4.21.50.481
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.481
1z71L17Prothrombin3.4.21.50.480
4dbw511Aldo-keto reductase family 1 member C3/0.480
1h22E10Acetylcholinesterase3.1.1.70.479
1ry8RUTAldo-keto reductase family 1 member C3/0.479
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.479
1u70MTXDihydrofolate reductase1.5.1.30.478
1zuaTOLAldo-keto reductase family 1 member B101.1.10.478
1gaqFADFerredoxin/0.477
1i7cMGBS-adenosylmethionine decarboxylase proenzyme4.1.1.500.477
1rkwPNTHTH-type transcriptional regulator QacR/0.477
1zgcA2EAcetylcholinesterase3.1.1.70.477
2d06ESTSulfotransferase 1A12.8.2.10.477
2fzdTOLAldose reductase1.1.1.210.477
2pksG44Prothrombin3.4.21.50.477
2uuj896Prothrombin3.4.21.50.477
1frbZSTAldose reductase-related protein 2/0.476
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.476
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.476
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.476
2rd2QSIGlutamine--tRNA ligase6.1.1.180.476
3ndjJHZMethyltransferase/0.476
3nn6HNK6-hydroxy-L-nicotine oxidase/0.476
3cr0809Wee1-like protein kinase2.7.10.20.475
3hv3R49Mitogen-activated protein kinase 14/0.475
4bfxZVXPantothenate kinase2.7.1.330.475
1rxjBNIStreptavidin/0.474
2bdyUNBProthrombin3.4.21.50.474
2pdh47DAldose reductase1.1.1.210.474
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.474
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.474
3r8gIZPAldo-keto reductase family 1 member C3/0.474
3rviRVIBeta-secretase 13.4.23.460.474
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.474
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.473
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.473
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.473
2c2bSAMThreonine synthase 1, chloroplastic4.2.3.10.473
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.473
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.473
3qwc98PProthrombin3.4.21.50.473
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.473
3nyaJTZBeta-2 adrenergic receptor/0.473
1hp0AD3IAG-nucleoside hydrolase/0.472
2a4xBLMMitomycin-binding protein/0.472
2w3mFOLDihydrofolate reductase1.5.1.30.472
2zhe13UProthrombin3.4.21.50.472
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.472
4m6kFOLDihydrofolate reductase1.5.1.30.472
1kf6HQOFumarate reductase iron-sulfur subunit1.3.5.10.471
1kf6HQOFumarate reductase subunit C/0.471
1kf6HQOFumarate reductase subunit D/0.471
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.471
1xf0ASDAldo-keto reductase family 1 member C3/0.471
2hxzH7JCathepsin S3.4.22.270.471
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.471
4m6l21VDihydrofolate reductase1.5.1.30.471
4mprTPPBenzoylformate decarboxylase4.1.1.70.471
3cv6HXSAldo-keto reductase family 1 member C21/0.470
4e32DWNMethyltransferase/0.470
4jpg1OXPyruvate kinase PKM2.7.1.400.470
1x8lOXRRetinol dehydratase/0.469
2gyuHI6Acetylcholinesterase3.1.1.70.469
3d80Q22Dihydrofolate reductase1.5.1.30.469
4arbC57Acetylcholinesterase3.1.1.70.469
4jq1NPSAldo-keto reductase family 1 member C2/0.469
2vqjTFGHistone deacetylase 43.5.1.980.468
4kfjFOLDihydrofolate reductase1.5.1.30.468
1a69FMBPurine nucleoside phosphorylase DeoD-type/0.467
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.467
1mvtDTMDihydrofolate reductase1.5.1.30.467
1ry0PG2Aldo-keto reductase family 1 member C3/0.467
2fz9ZSTAldose reductase1.1.1.210.467
2w6cBM4Acetylcholinesterase3.1.1.70.467
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.467
3h3qH13Collagen type IV alpha-3-binding protein/0.467
4xt8TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.467
5cxv0HKMuscarinic acetylcholine receptor M1/0.467
1pq944BOxysterols receptor LXR-beta/0.466
2pdwFIDAldose reductase1.1.1.210.466
3of3DIHPurine nucleoside phosphorylase DeoD-type 1/0.466
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.466
4hmn16JAldo-keto reductase family 1 member C3/0.466
4kebFOLDihydrofolate reductase1.5.1.30.466
1qtiGNTAcetylcholinesterase3.1.1.70.465
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.465
2in6839Wee1-like protein kinase2.7.10.20.465
2nvcITAAldose reductase1.1.1.210.465
2qjpANJCytochrome b/0.465
2zdv37UProthrombin3.4.21.50.465
3r94FLRAldo-keto reductase family 1 member C3/0.465
4n3l2FNProthrombin3.4.21.50.465
4ttjFMCPurine nucleoside phosphorylase DeoD-type/0.465
5e9eANPMyosin heavy chain kinase A2.7.11.70.465
1eveE20Acetylcholinesterase3.1.1.70.464
2y01Y00Beta-1 adrenergic receptor/0.464
3l3rOAGDihydrofolate reductase1.5.1.30.464
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
4bjbP34Tankyrase-22.4.2.300.464
4m0cFMNFMN-dependent NADH-azoreductase 1/0.464
4x3uSVRChromobox protein homolog 7/0.464
1ah0SBIAldose reductase1.1.1.210.463
1e66HUXAcetylcholinesterase3.1.1.70.463
1yw9A84Methionine aminopeptidase 2/0.463
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.463
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.463
3occDIHPurine nucleoside phosphorylase DeoD-type/0.463
4awtFMNNADH:flavin oxidoreductase Sye1/0.463
4tmcFMNOld yellow enzyme/0.463
1uhhCZPAequorin-2/0.462
1ypmRA4Prothrombin3.4.21.50.462
2pdfZSTAldose reductase1.1.1.210.462
2xuoTZ4Acetylcholinesterase3.1.1.70.462
3d4bDZDNAD-dependent protein deacetylase/0.462
3gkiCLRNiemann-Pick C1 protein/0.462
4bj9UHBTankyrase-22.4.2.300.462
4e7r0NWProthrombin3.4.21.50.462
4fhd0TTSpore photoproduct lyase/0.462
4gabFIDAldo-keto reductase family 1 member B101.1.10.462
4gm4TZDBenzoylformate decarboxylase4.1.1.70.462
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.461
1u65CP0Acetylcholinesterase3.1.1.70.461
2pdlTOLAldose reductase1.1.1.210.461
2xujTZ5Acetylcholinesterase3.1.1.70.461
3ghwGHWDihydrofolate reductase1.5.1.30.461
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.461
3lm4HPXCatechol 2,3-dioxygenase/0.461
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4e2zJHZMethyltransferase/0.461
4kn0MTXFolate receptor beta/0.461
1lkeDOGBilin-binding protein/0.460
1ohkCOPDihydrofolate reductase1.5.1.30.460
2ea4F79Methionine aminopeptidase 2/0.460
2vt4P32Beta-1 adrenergic receptor/0.460
2xuiTZ5Acetylcholinesterase3.1.1.70.460
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.460
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.460
1d3pBT3Prothrombin3.4.21.50.459
1d9i00PProthrombin3.4.21.50.459
1o2g696Prothrombin3.4.21.50.459
1s36CEIObelin/0.459
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.459
1ycfFMNNitric oxide reductase10.459
1ypeUIPProthrombin3.4.21.50.459
1yryMSGPurine nucleoside phosphorylase2.4.2.10.459
2iki388Aldose reductase1.1.1.210.459
2pdkSBIAldose reductase1.1.1.210.459
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.459
2zhf49UProthrombin3.4.21.50.459
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.459
3klbFMNUncharacterized protein/0.459
3zc3FADFerredoxin--NADP reductase1.18.1.20.459
4bcsBTNAvidin-related protein 4/5/0.459
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
4l5b1UXDeoxycytidine kinase2.7.1.740.459
1hfqMOTDihydrofolate reductase1.5.1.30.458
2cf8ESHProthrombin3.4.21.50.458
2ojg19AMitogen-activated protein kinase 12.7.11.240.458
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
4x9dU5PUncharacterized protein MJ1435/0.458
5a4wQCTGlutathione S-transferase F22.5.1.180.458
1gj5130Prothrombin3.4.21.50.457
1gw2FERPeroxidase C1A1.11.1.70.457
1jtqLY3Thymidylate synthase/0.457
1s3vTQDDihydrofolate reductase1.5.1.30.457
2a3bCFFEndochitinase B13.2.1.140.457
2aj4ANPGalactokinase2.7.1.60.457
2qimZEAClass 10 plant pathogenesis-related protein/0.457
2r2mI50Prothrombin3.4.21.50.457
2y035FWBeta-1 adrenergic receptor/0.457
2zg050UProthrombin3.4.21.50.457
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.457
3nxrD2DDihydrofolate reductase1.5.1.30.457
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.457
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.457
4nqgCZHMitrocomin/0.457
2ycxP32Beta-1 adrenergic receptor/0.457
1ej3CZHAequorin-2/0.456
1lnmDTXBilin-binding protein/0.456
1w76GNTAcetylcholinesterase3.1.1.70.456
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.456
2ejuSAHtRNA (guanine(26)-N(2))-dimethyltransferase/0.456
2gvcFADThiol-specific monooxygenase1.14.130.456
2ha6SCKAcetylcholinesterase3.1.1.70.456
2ohhFMNType A flavoprotein FprA10.456
3ix4TX1Transcriptional activator protein LasR/0.456
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4jq3ZOMAldo-keto reductase family 1 member C2/0.456
4jqaID8Aldo-keto reductase family 1 member C2/0.456
1ah3TOLAldose reductase1.1.1.210.455
1dx6GNTAcetylcholinesterase3.1.1.70.455
1kw9BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.455
1ut6A8NAcetylcholinesterase3.1.1.70.455
2cn0F25Prothrombin3.4.21.50.455
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.455
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.455
3cqeP91Wee1-like protein kinase2.7.10.20.455
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.455
3ha5SFGHydroxymycolate synthase MmaA42.1.10.455
3pn1IVHDNA ligase/0.455
3r8hZOMAldo-keto reductase family 1 member C3/0.455
3rtnRTNBeta-secretase 13.4.23.460.455
3wtkTH4Acetylcholine-binding protein/0.455
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.455
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.455
4j7hTRHPCZA361.3/0.455
5agyGTBTau class glutathione S-transferase/0.455
5dv2C5PCCR4-NOT transcription complex subunit 6-like3.1.13.40.455
1gky5GPGuanylate kinase2.7.4.80.454
1s3uTQDDihydrofolate reductase1.5.1.30.454
1t4v14AProthrombin3.4.21.50.454
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
1zq5E04Aldo-keto reductase family 1 member C3/0.454
2pdbZSTAldose reductase1.1.1.210.454
2vrjNCWBeta-glucosidase A3.2.1.210.454
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3c3xNAPEugenol synthase 11.1.1.3180.454
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
3rl35GPMetallophosphoesterase MPPED23.10.454
3rthRTHBeta-secretase 13.4.23.460.454
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.454
1ieiZESAldose reductase1.1.1.210.453
1ycgFMNNitric oxide reductase10.453
1z8962PAldose reductase1.1.1.210.453
2pd5ZSTAldose reductase1.1.1.210.453
2uuk897Prothrombin3.4.21.50.453
3fowIMHPurine nucleoside phosphorylase/0.453
3v35NTIAldose reductase1.1.1.210.453
4b7zQ4QAcetylcholinesterase3.1.1.70.453
4dvi2IWTankyrase-12.4.2.300.453
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.453
4iueAJ4Tankyrase-22.4.2.300.453
4jauADPSensor histidine kinase/0.453
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.453
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
1zgv501Prothrombin3.4.21.50.452
2cekN8TAcetylcholinesterase3.1.1.70.452
2hq9FADMll6688 protein/0.452
2nnqT4BFatty acid-binding protein, adipocyte/0.452
2xuqTZ4Acetylcholinesterase3.1.1.70.452
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.452
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.452
3ojgHL4Phosphotriesterase/0.452
3sfh1DIHistone deacetylase 83.5.1.980.452
4bamMM9Prothrombin3.4.21.50.452
4c73TLH3-oxoacyl-ACP synthase/0.452
4cthRDFNeprilysin/0.452
4dz5NAPAldo-keto reductase family 1 member C3/0.452
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4h380YXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.452
4jtrIZPAldo-keto reductase family 1 member C2/0.452
4k4eK4ETankyrase-12.4.2.300.452
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
5jqhCAUBeta-2 adrenergic receptor/0.452
3ny8JRZBeta-2 adrenergic receptor/0.452
1m9hNAD2,5-diketo-D-gluconic acid reductase A1.1.1.3460.451
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.451
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.451
2j3qTFLAcetylcholinesterase3.1.1.70.451
2v3hI25Prothrombin3.4.21.50.451
2wu4HBPAcetylcholinesterase3.1.1.70.451
3ko3ADPD-tyrosyl-tRNA(Tyr) deacylase/0.451
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.451
3znoSE5D-amino-acid oxidase1.4.3.30.451
4araC56Acetylcholinesterase3.1.1.70.451
4ey7E20Acetylcholinesterase3.1.1.70.451
4g0k0VSGlutathionyl-hydroquinone reductase YqjG1.80.451
1d4pBPPProthrombin3.4.21.50.450
1pwlBFIAldose reductase1.1.1.210.450
1uhjCZBAequorin-2/0.450
2dv0ZSTAldose reductase1.1.1.210.450
2j7cIDEBeta-glucosidase A3.2.1.210.450
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.450
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.450
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.450
3eq02TSProthrombin3.4.21.50.450
3k4551PDihydrofolate reductase1.5.1.30.450
3rl45GPMetallophosphoesterase MPPED23.10.450
3vf60H6Glucokinase2.7.1.20.450
4e2yJHZMethyltransferase/0.450
4gvsF4MMethenyltetrahydromethanopterin cyclohydrolase3.5.4.270.450
4p9dTMPDeoxycytidylate deaminase/0.450
5arkUMPRibonuclease 43.1.270.450
5liu388Aldo-keto reductase family 1 member B101.1.10.450
1fmlRTLRetinol dehydratase/0.449
1icsFMN12-oxophytodienoate reductase 11.3.1.420.449
1ohjCOPDihydrofolate reductase1.5.1.30.449
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.449
3dux64UProthrombin3.4.21.50.449
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3gcq1BUMitogen-activated protein kinase 14/0.449
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.449
3ou2SAHSAM-dependent methyltransferase/0.449
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4bjcRPBTankyrase-22.4.2.300.449
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4ey6GNTAcetylcholinesterase3.1.1.70.449
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4necSAHPutative SAM-dependent methyltransferase/0.449
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.449
1gpnHUBAcetylcholinesterase3.1.1.70.448
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.448
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.448
1xzqFONtRNA modification GTPase MnmE3.6.50.448
2fzbTOLAldose reductase1.1.1.210.448
2weaPP6Penicillopepsin-13.4.23.200.448
2xupTZ5Acetylcholinesterase3.1.1.70.448
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.448
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.448
3dz4C8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.448
3f3y4OABile salt sulfotransferase2.8.2.140.448
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.448
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.448
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.448
4jvlESTEstrogen sulfotransferase2.8.2.40.448
1ae8AZLProthrombin3.4.21.50.447
1i7mCGS-adenosylmethionine decarboxylase proenzyme4.1.1.500.447
1odjGMPPurine nucleoside phosphorylase/0.447
2cbqTH2Neocarzinostatin/0.447
2cmfF11Acetylcholinesterase3.1.1.70.447
2hejNDPAldo-keto reductase family 1 member C211.1.10.447
2mokFMNFlavodoxin 1/0.447
2rtqIMIStreptavidin/0.447
2whqHI6Acetylcholinesterase3.1.1.70.447
2y02WHJBeta-1 adrenergic receptor/0.447
3fsjD7KBenzoylformate decarboxylase4.1.1.70.447
3hfbML4Tryptophan 5-hydroxylase 11.14.16.40.447
3p2hNOOAcyl-homoserine-lactone synthase/0.447
4b66NAPL-ornithine N(5)-monooxygenase/0.447
4kmzFOLFolate receptor beta/0.447
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.447
4wcxSAMBiotin and thiamin synthesis associated/0.447
5f59SAHHistone-lysine N-methyltransferase 2C2.1.1.430.447
1ekoI84Aldose reductase1.1.1.210.446
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.446
2ejzSAHDiphthine synthase/0.446
2iqdLPAAldose reductase1.1.1.210.446
2xufTZ4Acetylcholinesterase3.1.1.70.446
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3gxfIFMGlucosylceramidase3.2.1.450.446
3mb9ZSTAldose reductase1.1.1.210.446
3owxXRARibosyldihydronicotinamide dehydrogenase [quinone]/0.446
3sfy3FYUncharacterized protein/0.446
3zg6APRNAD-dependent protein deacetylase sirtuin-63.5.10.446
3zj6VM2Raucaffricine-O-beta-D-glucosidase3.2.1.1250.446
4a39GEMUncharacterized protein/0.446
4az29MUProthrombin3.4.21.50.446
4bz8J38Histone deacetylase/0.446
4l091URTankyrase-22.4.2.300.446
5d7pAR6NAD-dependent protein deacetylase sirtuin-23.5.10.446
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.446
1ex75GPGuanylate kinase2.7.4.80.445
1h69ARHNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1odiADNPurine nucleoside phosphorylase/0.445
1pke2FDPurine nucleoside phosphorylase DeoD-type/0.445
1x1bSAHC-20 methyltransferase/0.445
2b8jADNClass B acid phosphatase3.1.3.20.445
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.445
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.445
2inzOHPAldose reductase1.1.1.210.445
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.445
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.445
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.445
3arvSAUChitinase A/0.445
3iej599Cathepsin S3.4.22.270.445
3jq6DX1Pteridine reductase, putative/0.445
4b66FADL-ornithine N(5)-monooxygenase/0.445
4h8i11WGlutamate receptor ionotropic, kainate 2/0.445
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4kn2LYAFolate receptor beta/0.445
4l321VFTankyrase-22.4.2.300.445
4mt92D6Tankyrase-12.4.2.300.445
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.445
5dsg0HKMuscarinic acetylcholine receptor M4/0.445
5d5aCAUBeta-2 adrenergic receptor/0.445
1icqOPD12-oxophytodienoate reductase 11.3.1.420.444
1nc1MTH5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase3.2.2.90.444
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.444
2w6pOA4Biotin carboxylase6.3.4.140.444
2xnvVU3Soluble acetylcholine receptor/0.444
3c35KAIGlutamate receptor ionotropic, kainate 1/0.444
3cuiX4SExoglucanase/xylanase3.2.1.910.444
3ghrLDTAldose reductase1.1.1.210.444
3ntz3TZDihydrofolate reductase1.5.1.30.444
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.444
3wqmB29Diterpene synthase3.1.7.80.444
3zkyWT4Isopenicillin N synthase1.21.3.10.444
4avwG18Tankyrase-22.4.2.300.444
4jaqCOAAlpha-pyrone synthesis polyketide synthase-like Pks112.3.10.444
4kxjP34Nucleoprotein/0.444
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.444
3ny9JSZBeta-2 adrenergic receptor/0.444
1a4wQWEProthrombin3.4.21.50.443
1c4uIH1Prothrombin3.4.21.50.443
1dghNDPCatalase1.11.1.60.443
1fmjRTLRetinol dehydratase/0.443
1fxvPNNPenicillin G acylase3.5.1.110.443
1gt5BZQOdorant-binding protein/0.443
1j0b5PAPutative 1-aminocyclopropane-1-carboxylate deaminase3.5.99.70.443
1nc9IMIStreptavidin/0.443
1pj6FOLDimethylglycine oxidase1.5.3.100.443
1qoqIGPTryptophan synthase alpha chain/0.443
1s07PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.443
1u0wSTLChalcone synthase 22.3.1.740.443
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.443
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2op18PCEnoyl-ACP reductase/0.443
2vq3NAPMetalloreductase STEAP3/0.443
2wjoQUDBeta-secretase 13.4.23.460.443
2wzySQXSoluble acetylcholine receptor/0.443
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.443
3f0aACOSpermidine N(1)-acetyltransferase/0.443
3ghvGHCDihydrofolate reductase1.5.1.30.443
3jqcJU2Pteridine reductase, putative/0.443
3nhlYTRRibosyldihydronicotinamide dehydrogenase [quinone]/0.443
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.443
3wznBTNStreptavidin/0.443
4e2xTYDMethyltransferase/0.443
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.443
4li61XOTankyrase-12.4.2.300.443
4lrhFOLFolate receptor alpha/0.443
4u95MIYMultidrug efflux pump subunit AcrB/0.443
5ab7MLCNonspecific lipid-transfer protein, putative/0.443
1g63FMNEpidermin decarboxylase4.1.10.442
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1ndiCOACarnitine O-acetyltransferase2.3.1.70.442
1t7o152Carnitine O-acetyltransferase2.3.1.70.442
2futH1SHeparin and heparin-sulfate lyase/0.442
2jgsBTNAvidin/0.442
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2v7qADPATP synthase subunit beta, mitochondrial3.6.3.140.442
2zhw12UProthrombin3.4.21.50.442
3gg2UGASugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family/0.442
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.442
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.442
4awsFMNNADH:flavin oxidoreductase Sye1/0.442
4bfwZVWPantothenate kinase2.7.1.330.442
4eh8IRGMitogen-activated protein kinase 14/0.442
4gt8ADPSensor protein VraS2.7.13.30.442
4hlh20DTankyrase-22.4.2.300.442
4uy6SAHHistidine N-alpha-methyltransferase/0.442
5ero210Fusicoccadiene synthase2.5.1.290.442
3d4sTIMBeta-2 adrenergic receptor/0.442
1lelBH7Avidin/0.441
1m3qANGN-glycosylase/DNA lyase3.2.20.441
1nzq162Prothrombin3.4.21.50.441
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
1w29TS16,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1yhjR6CPyridoxal kinase2.7.1.350.441
1yw7A41Methionine aminopeptidase 2/0.441
2flhZEACytokinin-specific binding protein/0.441
2g7yMO9Cathepsin S3.4.22.270.441
2gouFMNNADH:flavin oxidoreductase Sye1/0.441
2j7dGI1Beta-glucosidase A3.2.1.210.441
2wkyIBCGlutamate receptor ionotropic, kainate 1/0.441
2x9vTMQPteridine reductase/0.441
2zsdCOAPantothenate kinase2.7.1.330.441
3a8iC2FAminomethyltransferase2.1.2.100.441
3bldPRFQueuine tRNA-ribosyltransferase2.4.2.290.441
3c36KAIGlutamate receptor ionotropic, kainate 1/0.441
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.441
3o8hO8HHTH-type transcriptional regulator EthR/0.441
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
4pl9ADPEthylene receptor 1/0.441
4pnmNU1Tankyrase-22.4.2.300.441
4yfy0FXVioF/0.441
5a4vQUEGlutathione S-transferase F22.5.1.180.441
5d6lCAUBeta-2 adrenergic receptor/0.441
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.440
1h36R88Squalene--hopene cyclase4.2.1.1290.440
1itzTPPTransketolase, chloroplastic2.2.1.10.440
1t5bFMNFMN-dependent NADH-azoreductase/0.440
1z5uCMPClass B acid phosphatase/0.440
2cf9348Prothrombin3.4.21.50.440
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.440
2ikhLITAldose reductase1.1.1.210.440
2jf0HBPAcetylcholinesterase3.1.1.70.440
2pucGUNHTH-type transcriptional repressor PurR/0.440
2vqqTFGHistone deacetylase 43.5.1.980.440
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.440
2xysSY9Soluble acetylcholine receptor/0.440
2yw9NAPEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
2zgb21UProthrombin3.4.21.50.440
3bi6396Wee1-like protein kinase2.7.10.20.440
3dz6M8ES-adenosylmethionine decarboxylase proenzyme4.1.1.500.440
3ekuCY9Actin-5C/0.440
3g5iDNBPyrimidine-specific ribonucleoside hydrolase RihA/0.440
3juoAJDPhenazine biosynthesis protein A/B/0.440
3k47D09Dihydrofolate reductase1.5.1.30.440
3lmhADPMyosin heavy chain kinase A2.7.11.70.440
3nhrRZWRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3zpqXF5Beta-1 adrenergic receptor/0.440
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.440
4jtpASCRibosome inactivating protein/0.440
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440