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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z3n3NAAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1z3n3NAAldose reductase1.1.1.211.000
2i16LDTAldose reductase1.1.1.210.754
3g5eQ74Aldose reductase1.1.1.210.743
1t40ID5Aldose reductase1.1.1.210.721
3lboLDTAldose reductase1.1.1.210.705
2qxwLDTAldose reductase1.1.1.210.693
3ghuLDTAldose reductase1.1.1.210.690
2duxZSTAldose reductase1.1.1.210.684
2hv5ZSTAldose reductase1.1.1.210.671
2iki388Aldose reductase1.1.1.210.666
1us0LDTAldose reductase1.1.1.210.665
2duzZSTAldose reductase1.1.1.210.664
2dv0ZSTAldose reductase1.1.1.210.662
3mb9ZSTAldose reductase1.1.1.210.662
2fz8ZSTAldose reductase1.1.1.210.661
3lqlLDTAldose reductase1.1.1.210.661
2pzn393Aldose reductase1.1.1.210.658
2hvoZSTAldose reductase1.1.1.210.653
3ghrLDTAldose reductase1.1.1.210.653
1z8962PAldose reductase1.1.1.210.649
2i17LDTAldose reductase1.1.1.210.644
4yu153NAldose reductase1.1.1.210.639
2fz9ZSTAldose reductase1.1.1.210.637
3m4h388Aldose reductase1.1.1.210.634
3ld5LDTAldose reductase1.1.1.210.633
2ikhLITAldose reductase1.1.1.210.630
2pdxZSTAldose reductase1.1.1.210.627
3m64393Aldose reductase1.1.1.210.624
2pdbZSTAldose reductase1.1.1.210.617
2pdc393Aldose reductase1.1.1.210.616
3ghsLDTAldose reductase1.1.1.210.616
1pwlBFIAldose reductase1.1.1.210.615
3t423T4Aldose reductase1.1.1.210.615
1t41ID5Aldose reductase1.1.1.210.611
3ghtLDTAldose reductase1.1.1.210.608
3lenZSTAldose reductase1.1.1.210.605
2ikj393Aldose reductase1.1.1.210.604
2pd5ZSTAldose reductase1.1.1.210.604
2pdu393Aldose reductase1.1.1.210.603
2pdp393Aldose reductase1.1.1.210.599
2pdn47DAldose reductase1.1.1.210.596
3mc5393Aldose reductase1.1.1.210.591
2pdh47DAldose reductase1.1.1.210.590
2pdlTOLAldose reductase1.1.1.210.587
4gca2X9Aldose reductase1.1.1.210.586
2pdfZSTAldose reductase1.1.1.210.580
2pdg47DAldose reductase1.1.1.210.573
1frbZSTAldose reductase-related protein 2/0.563
2fzdTOLAldose reductase1.1.1.210.561
1ieiZESAldose reductase1.1.1.210.557
2pdj393Aldose reductase1.1.1.210.545
2pdq47DAldose reductase1.1.1.210.536
1ah3TOLAldose reductase1.1.1.210.530
2fzbTOLAldose reductase1.1.1.210.530
1zuaTOLAldo-keto reductase family 1 member B101.1.10.513
3lz5LDTAldose reductase1.1.1.210.508
3mjrAC2Deoxycytidine kinase2.7.1.740.490
1ry8RUTAldo-keto reductase family 1 member C3/0.482
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.479
1el3I84Aldose reductase1.1.1.210.475
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
1ry0PG2Aldo-keto reductase family 1 member C3/0.473
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
3m0iZSTAldose reductase1.1.1.210.471
4ga8SBIAldo-keto reductase family 1 member B101.1.10.470
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
2xujTZ5Acetylcholinesterase3.1.1.70.467
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.462
1ekoI84Aldose reductase1.1.1.210.462
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.462
5liu388Aldo-keto reductase family 1 member B101.1.10.462
3f3y4OABile salt sulfotransferase2.8.2.140.459
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.459
2xuqTZ4Acetylcholinesterase3.1.1.70.458
1lnmDTXBilin-binding protein/0.457
2cekN8TAcetylcholinesterase3.1.1.70.457
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
2f2kTGGAldose reductase1.1.1.210.456
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.455
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.455
1s1rNAPAldo-keto reductase family 1 member C3/0.453
3n0hTOPDihydrofolate reductase1.5.1.30.453
4pnmNU1Tankyrase-22.4.2.300.453
4q7f3D1Uncharacterized protein/0.453
4ey7E20Acetylcholinesterase3.1.1.70.452
2jf0HBPAcetylcholinesterase3.1.1.70.451
2qimZEAClass 10 plant pathogenesis-related protein/0.451
2xuiTZ5Acetylcholinesterase3.1.1.70.451
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
4dbw511Aldo-keto reductase family 1 member C3/0.451
1e66HUXAcetylcholinesterase3.1.1.70.450
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
2aotSAHHistamine N-methyltransferase2.1.1.80.450
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.450
2zs9ADPPantothenate kinase2.7.1.330.450
2zsdCOAPantothenate kinase2.7.1.330.450
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4kn104JFolate receptor beta/0.450
4wevSUZAldo-keto reductase family 1 member B101.1.10.450
5stdUNNScytalone dehydratase4.2.1.940.450
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1zgcA2EAcetylcholinesterase3.1.1.70.449
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4e0u0MVCyclic dipeptide N-prenyltransferase/0.449
4kmzFOLFolate receptor beta/0.449
2iqdLPAAldose reductase1.1.1.210.448
2pdwFIDAldose reductase1.1.1.210.448
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.448
3c3xNAPEugenol synthase 11.1.1.3180.448
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
4araC56Acetylcholinesterase3.1.1.70.448
4li61XOTankyrase-12.4.2.300.448
1x1bSAHC-20 methyltransferase/0.447
2aot2PMHistamine N-methyltransferase2.1.1.80.447
2ckmAA7Acetylcholinesterase3.1.1.70.447
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.447
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.447
5fd8A5APutative carboxypeptidase yocD/0.447
2whqHI6Acetylcholinesterase3.1.1.70.446
2xupTZ5Acetylcholinesterase3.1.1.70.446
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.446
4k4eK4ETankyrase-12.4.2.300.446
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.445
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.444
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.444
2pdyFIDAldose reductase1.1.1.210.444
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.444
4pnrG18Tankyrase-22.4.2.300.444
1u65CP0Acetylcholinesterase3.1.1.70.443
2getCOKPantothenate kinase2.7.1.330.443
4lrhFOLFolate receptor alpha/0.443
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2xi4AFTAcetylcholinesterase3.1.1.70.442
3b82NADExotoxin A2.4.2.360.442
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
4bj9UHBTankyrase-22.4.2.300.442
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.442
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.441
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1xf0ASDAldo-keto reductase family 1 member C3/0.440
2gevCOKPantothenate kinase2.7.1.330.440
3q7fED2Uncharacterized protein/0.440
3r43ID8Aldo-keto reductase family 1 member C3/0.440
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4i9i1DYTankyrase-12.4.2.300.440
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440
4xwtU5PRibonuclease J/0.440
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.440
4u163C0Muscarinic acetylcholine receptor M3/0.440