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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z2nADPInositol-tetrakisphosphate 1-kinase2.7.1.134

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1z2nADPInositol-tetrakisphosphate 1-kinase2.7.1.1341.000
1z2pACPInositol-tetrakisphosphate 1-kinase2.7.1.1340.801
2vqdAP2Biotin carboxylase6.3.4.140.480
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.471
4ffrATPUncharacterized protein/0.451
1u1gBBBUridine phosphorylase2.4.2.30.447
4o4iACPTubulin tyrosine ligase/0.446
1sezOMNProtoporphyrinogen oxidase, mitochondrial1.3.3.40.445