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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ywrLI9Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ywrLI9Mitogen-activated protein kinase 14/1.000
3fln3FNMitogen-activated protein kinase 14/0.575
1ouk084Mitogen-activated protein kinase 14/0.572
3hl7I47Mitogen-activated protein kinase 14/0.569
3dt1P40Mitogen-activated protein kinase 14/0.564
4ewqMWLMitogen-activated protein kinase 14/0.556
1zyjBI5Mitogen-activated protein kinase 14/0.551
3s4qNK0Mitogen-activated protein kinase 14/0.551
3mpaSB2Mitogen-activated protein kinase 14/0.545
3gc9B45Mitogen-activated protein kinase 112.7.11.240.543
3roc29AMitogen-activated protein kinase 14/0.542
2ittAEEEpidermal growth factor receptor2.7.10.10.537
3uibSB2Putative mitogen-activated protein kinase/0.536
1bl6SB6Mitogen-activated protein kinase 14/0.535
3fmkFMKMitogen-activated protein kinase 14/0.534
3iphG11Mitogen-activated protein kinase 14/0.534
3fklFKLMitogen-activated protein kinase 14/0.531
3flzFLZMitogen-activated protein kinase 14/0.530
4lopSB4Mitogen-activated protein kinase 14/0.530
3flsFLSMitogen-activated protein kinase 14/0.529
3nww3NWMitogen-activated protein kinase 14/0.529
2balPQAMitogen-activated protein kinase 14/0.522
3fmh533Mitogen-activated protein kinase 14/0.522
3ha85JZMitogen-activated protein kinase 14/0.521
4nks2M2Fibroblast growth factor receptor 1/0.520
3uvqFS8Mitogen-activated protein kinase 14/0.519
1m7qDQOMitogen-activated protein kinase 14/0.518
3fmjFMJMitogen-activated protein kinase 14/0.517
3hllI45Mitogen-activated protein kinase 14/0.517
2ghlLIBMitogen-activated protein kinase 14/0.516
2itqITQEpidermal growth factor receptor2.7.10.10.516
1ouy094Mitogen-activated protein kinase 14/0.514
3gc7B45Mitogen-activated protein kinase 14/0.513
3gfeP37Mitogen-activated protein kinase 14/0.513
3mvl38PMitogen-activated protein kinase 14/0.512
2qd9LGFMitogen-activated protein kinase 14/0.511
3fi4FI4Mitogen-activated protein kinase 14/0.511
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.510
2ghmLICMitogen-activated protein kinase 14/0.508
3gubGUBDeath-associated protein kinase 12.7.11.10.507
4aa4QC0Mitogen-activated protein kinase 14/0.507
1zzlTZYMitogen-activated protein kinase 14/0.506
3flyFLYMitogen-activated protein kinase 14/0.504
3igoANPCalmodulin-domain protein kinase 1, putative/0.504
3kf7L9GMitogen-activated protein kinase 14/0.504
4jrvKJVEpidermal growth factor receptor2.7.10.10.504
4aa5NQBMitogen-activated protein kinase 14/0.503
3fl4FL4Mitogen-activated protein kinase 14/0.502
3fmn530Mitogen-activated protein kinase 14/0.502
3ocgOCGMitogen-activated protein kinase 14/0.502
1w84L12Mitogen-activated protein kinase 14/0.501
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.500
2itpAEEEpidermal growth factor receptor2.7.10.10.499
4fob0USALK tyrosine kinase receptor2.7.10.10.499
4ic7ANPMitogen-activated protein kinase 72.7.11.240.499
1m17AQ4Epidermal growth factor receptor2.7.10.10.498
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.498
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.498
3hp552PMitogen-activated protein kinase 14/0.497
3hvcGG5Mitogen-activated protein kinase 14/0.497
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.495
3fknFKNMitogen-activated protein kinase 14/0.495
4anqVGHALK tyrosine kinase receptor2.7.10.10.495
4kbk1QGCasein kinase I isoform delta2.7.11.10.495
4looSB4Mitogen-activated protein kinase 14/0.493
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.493
3fkoFKOMitogen-activated protein kinase 14/0.492
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.492
3fc152PMitogen-activated protein kinase 14/0.491
3fmlFMLMitogen-activated protein kinase 14/0.490
4i22IREEpidermal growth factor receptor2.7.10.10.490
4kip1R9Mitogen-activated protein kinase 14/0.490
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.489
3flwFLWMitogen-activated protein kinase 14/0.489
3fmmXI2Mitogen-activated protein kinase 14/0.489
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.489
4kiq1RAMitogen-activated protein kinase 14/0.489
1oz1FPHMitogen-activated protein kinase 14/0.488
2itnANPEpidermal growth factor receptor2.7.10.10.487
3itzP66Mitogen-activated protein kinase 14/0.487
4nc3ERM5-hydroxytryptamine receptor 2B/0.487
3w33W19Epidermal growth factor receptor2.7.10.10.486
4kbc1QJCasein kinase I isoform delta2.7.11.10.485
4nka2K7Fibroblast growth factor receptor 1/0.485
3fskRO6Mitogen-activated protein kinase 14/0.484
3zsh469Mitogen-activated protein kinase 14/0.484
2zb0GK3Mitogen-activated protein kinase 14/0.483
3o8tBMUMitogen-activated protein kinase 14/0.483
4eh50OMMitogen-activated protein kinase 14/0.483
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.483
5f0a1FBcGMP-dependent protein kinase, putative/0.483
3hub469Mitogen-activated protein kinase 14/0.482
3l8xN4DMitogen-activated protein kinase 14/0.482
3mpt1GKMitogen-activated protein kinase 14/0.482
3uvp048Mitogen-activated protein kinase 14/0.482
3obgSB2Mitogen-activated protein kinase 14/0.480
4jq7KJQEpidermal growth factor receptor2.7.10.10.479
4kin1M8Mitogen-activated protein kinase 14/0.477
2bujSTUSerine/threonine-protein kinase 16/0.476
4f630S7Fibroblast growth factor receptor 1/0.476
4bgg844Activin receptor type-12.7.11.300.475
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.474
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.473
2ewaSB2Mitogen-activated protein kinase 14/0.473
2fgiPD1Fibroblast growth factor receptor 1/0.473
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.473
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.473
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.473
4ansVGHALK tyrosine kinase receptor2.7.10.10.472
1ove358Mitogen-activated protein kinase 14/0.471
1yw2PGJMitogen-activated protein kinase 14/0.471
2itwITQEpidermal growth factor receptor2.7.10.10.471
4wboANWRhodopsin kinase/0.471
2pwlACPFibroblast growth factor receptor 2/0.470
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.470
3vjoANPEpidermal growth factor receptor2.7.10.10.470
4yuqKS1Calmodulin-like domain protein kinase/0.470
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.469
4loqSB4Mitogen-activated protein kinase 14/0.469
4nk92K5Fibroblast growth factor receptor 1/0.469
1vyw292Cyclin-dependent kinase 22.7.11.220.468
4g170VNCasein kinase I isoform gamma-32.7.11.10.468
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
2itzIREEpidermal growth factor receptor2.7.10.10.467
2rg6287Mitogen-activated protein kinase 14/0.467
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.467
4f640S8Fibroblast growth factor receptor 1/0.467
2rg5279Mitogen-activated protein kinase 14/0.466
3mtfA3FActivin receptor type-12.7.11.300.466
3q5iANPProtein kinase, putative/0.466
3t8oATPRhodopsin kinase/0.466
3tucFPWTyrosine-protein kinase SYK2.7.10.20.466
4hnf16WCasein kinase I isoform delta2.7.11.10.466
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3a7hATPSerine/threonine-protein kinase 242.7.11.10.465
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.465
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.465
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.463
2ckeIQUDeath-associated protein kinase 2/0.463
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.463
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.463
4hni16WCasein kinase I isoform epsilon2.7.11.10.463
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.462
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.462
2i0ePDSProtein kinase C beta type2.7.11.130.461
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.461
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.461
4kb81QNCasein kinase I isoform delta2.7.11.10.461
4kba1QMCasein kinase I isoform delta2.7.11.10.461
5aaaVGHALK tyrosine kinase receptor2.7.10.10.461
2o0uC0MMitogen-activated protein kinase 102.7.11.240.460
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.459
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.459
3w2sW2REpidermal growth factor receptor2.7.10.10.459
3zsgT75Mitogen-activated protein kinase 14/0.459
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.459
4iebANPCalmodulin-domain protein kinase 1/0.459
4xhgADPUncharacterized protein/0.459
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.458
2cchATPCyclin-dependent kinase 22.7.11.220.458
2zybKSLTyrosine-protein kinase Lck2.7.10.20.458
3uyt0CKCasein kinase I isoform delta2.7.11.10.458
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.458
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.457
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
4e730NRMitogen-activated protein kinase 82.7.11.240.457
2hk51BMTyrosine-protein kinase HCK2.7.10.20.456
2hog710Serine/threonine-protein kinase Chk12.7.11.10.456
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.456
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.456
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.456
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.456
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
1bl7SB4Mitogen-activated protein kinase 14/0.455
1blzACVIsopenicillin N synthase1.21.3.10.455
2of2547Tyrosine-protein kinase Lck2.7.10.20.455
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.455
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.455
1k6pXN3Gag-Pol polyprotein3.4.23.160.454
2excJNKMitogen-activated protein kinase 102.7.11.240.454
3mvm39PMitogen-activated protein kinase 14/0.454
3ttjJBIMitogen-activated protein kinase 102.7.11.240.454
4qo9627Serine/threonine-protein kinase 242.7.11.10.454
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.453
2cahNDPCatalase1.11.1.60.453
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.453
2itxANPEpidermal growth factor receptor2.7.10.10.453
2yfxVGHALK tyrosine kinase receptor2.7.10.10.453
3ormAGSSerine/threonine protein kinase/0.453
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4c02TAKActivin receptor type-12.7.11.300.453
4hyu1BKMitogen-activated protein kinase 82.7.11.240.453
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.453
2b1pAIZMitogen-activated protein kinase 102.7.11.240.452
2pvyACPFibroblast growth factor receptor 2/0.452
3c50ADPRhodopsin kinase/0.452
4gk3L87Ephrin type-A receptor 32.7.10.10.452
4l4cCAMCamphor 5-monooxygenase1.14.15.10.452
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
1ci7UMPThymidylate synthase2.1.1.450.451
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.451
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.451
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.451
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.451
4cd2FOLDihydrofolate reductase1.5.1.30.451
1yqj6NPMitogen-activated protein kinase 14/0.450
2c7xNRBCytochrome P450 monooxygenase PikC/0.450
2henADPEphrin type-B receptor 22.7.10.10.450
3c4xATPRhodopsin kinase/0.450
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.450
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.450
4fuxE75Mitogen-activated protein kinase 12.7.11.240.450
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.449
2vwx7X4Ephrin type-B receptor 42.7.10.10.449
2vx07X7Ephrin type-B receptor 42.7.10.10.449
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.449
3ds6A17Mitogen-activated protein kinase 14/0.449
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.449
4bcqTJFCyclin-dependent kinase 22.7.11.220.449
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.449
4i231C9Epidermal growth factor receptor2.7.10.10.449
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2ituITQEpidermal growth factor receptor2.7.10.10.448
2y6o1N1Ephrin type-A receptor 42.7.10.10.448
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
5auwQUEDeath-associated protein kinase 12.7.11.10.448
1kgjFL8Transthyretin/0.447
1zz2B11Mitogen-activated protein kinase 14/0.447
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.447
2ftoCB3Thymidylate synthase/0.447
3hucG97Mitogen-activated protein kinase 14/0.447
3t1tGDPProbable gliding protein mglA/0.447
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.447
4cd0AWJALK tyrosine kinase receptor2.7.10.10.447
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
4qnaX11Serine/threonine-protein kinase 242.7.11.10.447
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.446
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.446
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.446
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.446
5e8xSTUTGF-beta receptor type-12.7.11.300.446
2eb3ANPEpidermal growth factor receptor2.7.10.10.445
2wihP48Cyclin-dependent kinase 22.7.11.220.445
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.445
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.445
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.445
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.445
1ie4T44Transthyretin/0.444
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
1nzdUPGDNA beta-glucosyltransferase/0.444
1x2hLPALipoate-protein ligase A6.3.1.200.444
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.444
2izsBRQCasein kinase I isoform gamma-32.7.11.10.444
2qo9ANPEphrin type-A receptor 32.7.10.10.444
3lltANPProtein serine/threonine kinase-1/0.444
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.444
4dce0JFALK tyrosine kinase receptor2.7.10.10.444
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.443
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.443
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.443
2xp2VGHALK tyrosine kinase receptor2.7.10.10.443
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3d7tSTUTyrosine-protein kinase CSK/0.443
3l0lHC3Nuclear receptor ROR-gamma/0.443
3mdvCL6Cholesterol 24-hydroxylase/0.443
3oc1BMUMitogen-activated protein kinase 14/0.443
3s2pPMUCyclin-dependent kinase 22.7.11.220.443
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.443
4gk2L66Ephrin type-A receptor 32.7.10.10.443
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
4nj32KDCyclin-dependent kinase 22.7.11.220.443
4riyADPEpidermal growth factor receptor2.7.10.10.443
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.442
2etm7PYFocal adhesion kinase 12.7.10.20.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
4ccbOFGALK tyrosine kinase receptor2.7.10.10.442
4g1wG1WMitogen-activated protein kinase 82.7.11.240.442
4izy1J2Mitogen-activated protein kinase 82.7.11.240.442
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.442
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.442
1k6cMK1Gag-Pol polyprotein3.4.23.160.441
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.441
1xkkFMMEpidermal growth factor receptor2.7.10.10.441
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2gfsPQBMitogen-activated protein kinase 14/0.441
2vd5BI8Myotonin-protein kinase2.7.11.10.441
3icsADPCoenzyme A disulfide reductase/0.441
3l8p0CEAngiopoietin-1 receptor2.7.10.10.441
3oom507Activin receptor type-12.7.11.300.441
3q92XNBKetohexokinase/0.441
1ir3ANPInsulin receptor2.7.10.10.440
1uomPTIEstrogen receptor/0.440
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.440
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.440
3iw5DF3Mitogen-activated protein kinase 14/0.440
3uwqU5POrotidine 5'-phosphate decarboxylase/0.440
4eh60ONMitogen-activated protein kinase 14/0.440