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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yvj4STTyrosine-protein kinase JAK32.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1yvj4STTyrosine-protein kinase JAK32.7.10.21.000
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.513
4hvi19STyrosine-protein kinase JAK32.7.10.20.511
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.470
4hge15VTyrosine-protein kinase JAK2/0.463
3lpbNVBTyrosine-protein kinase JAK2/0.459
4bbfO19Tyrosine-protein kinase JAK2/0.451
4bbe3O4Tyrosine-protein kinase JAK2/0.447
3w2rW2REpidermal growth factor receptor2.7.10.10.446
4aqc88ATyrosine-protein kinase JAK2/0.446
4ji91M3Tyrosine-protein kinase JAK2/0.445
4e6q0NVTyrosine-protein kinase JAK2/0.442
4jia1K3Tyrosine-protein kinase JAK2/0.440