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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yqj6NPMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1yqj6NPMitogen-activated protein kinase 14/1.000
3zsh469Mitogen-activated protein kinase 14/0.515
3fl4FL4Mitogen-activated protein kinase 14/0.514
3itzP66Mitogen-activated protein kinase 14/0.500
1ouk084Mitogen-activated protein kinase 14/0.499
1ftlDNQGlutamate receptor 2/0.498
3flsFLSMitogen-activated protein kinase 14/0.498
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.495
3fmlFMLMitogen-activated protein kinase 14/0.494
3fkoFKOMitogen-activated protein kinase 14/0.491
1zzlTZYMitogen-activated protein kinase 14/0.489
1ove358Mitogen-activated protein kinase 14/0.488
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.486
3fmmXI2Mitogen-activated protein kinase 14/0.486
1lb9DNQGlutamate receptor 2/0.484
1ywrLI9Mitogen-activated protein kinase 14/0.484
3flyFLYMitogen-activated protein kinase 14/0.481
4ewqMWLMitogen-activated protein kinase 14/0.480
3fmn530Mitogen-activated protein kinase 14/0.479
3flzFLZMitogen-activated protein kinase 14/0.477
3fknFKNMitogen-activated protein kinase 14/0.475
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
1bl6SB6Mitogen-activated protein kinase 14/0.473
3l8sBFFMitogen-activated protein kinase 14/0.472
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.471
3dt1P40Mitogen-activated protein kinase 14/0.470
4nks2M2Fibroblast growth factor receptor 1/0.469
2pupADPMethylthioribose kinase2.7.1.1000.468
4iarERM5-hydroxytryptamine receptor 1B/0.468
1ouy094Mitogen-activated protein kinase 14/0.465
1w7h3IPMitogen-activated protein kinase 14/0.465
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.465
4mv1ADPBiotin carboxylase6.3.4.140.464
1zhzERGOxysterol-binding protein homolog 4/0.463
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.462
2ewaSB2Mitogen-activated protein kinase 14/0.462
2fszOHTEstrogen receptor beta/0.462
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.461
2vn1FK5Peptidylprolyl isomerase/0.460
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.460
2puiADPMethylthioribose kinase2.7.1.1000.459
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
4f1yCNIGlutamate receptor 3/0.459
1m7qDQOMitogen-activated protein kinase 14/0.458
2gfsPQBMitogen-activated protein kinase 14/0.458
3ha85JZMitogen-activated protein kinase 14/0.458
4eh60ONMitogen-activated protein kinase 14/0.458
1yinCM3Estrogen receptor/0.457
4nc3ERM5-hydroxytryptamine receptor 2B/0.457
1bmkSB5Mitogen-activated protein kinase 14/0.456
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.456
3iw5DF3Mitogen-activated protein kinase 14/0.456
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.456
4k9yK9YFocal adhesion kinase 12.7.10.20.456
2ittAEEEpidermal growth factor receptor2.7.10.10.455
3kf7L9GMitogen-activated protein kinase 14/0.455
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3fmh533Mitogen-activated protein kinase 14/0.454
3gc9B45Mitogen-activated protein kinase 112.7.11.240.454
4iaq2GM5-hydroxytryptamine receptor 1B/0.454
1errRALEstrogen receptor/0.453
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.453
1xuoLA1Integrin alpha-L/0.453
3ns2PYVAbscisic acid receptor PYL2/0.453
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4isuIKMGlutamate receptor 2/0.453
2ydoADNAdenosine receptor A2a/0.452
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.452
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.452
1l2jETCEstrogen receptor beta/0.451
3hz5Z64Heat shock protein HSP 90-alpha/0.451
1qknRALEstrogen receptor beta/0.450
2yixYIXMitogen-activated protein kinase 14/0.450
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.450
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.449
2itpAEEEpidermal growth factor receptor2.7.10.10.449
4jvlESTEstrogen sulfotransferase2.8.2.40.449
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.448
3hk1B64Fatty acid-binding protein, adipocyte/0.448
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.448
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.448
4yekTHMThymidine phosphorylase/0.448
5k2aZMAAdenosine receptor A2a/0.448
2uxoTACHTH-type transcriptional regulator TtgR/0.447
3vt7VDXVitamin D3 receptor/0.447
5k2cZMAAdenosine receptor A2a/0.447
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3fln3FNMitogen-activated protein kinase 14/0.446
3juqAJDPhenazine biosynthesis protein A/B/0.446
4em9TCEPeroxisome proliferator-activated receptor gamma/0.446
4zbrNPSSerum albumin/0.446
1zyjBI5Mitogen-activated protein kinase 14/0.445
2yjxYJXHeat shock protein HSP 90-alpha/0.445
3fi4FI4Mitogen-activated protein kinase 14/0.445
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3ua506XCytochrome P450 2B61.14.130.445
4b8wNAPGDP-L-fucose synthase1.1.1.2710.445
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4iwc1GVEstrogen receptor/0.445
1x8b824Wee1-like protein kinase2.7.10.20.444
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3hl7I47Mitogen-activated protein kinase 14/0.444
4loqSB4Mitogen-activated protein kinase 14/0.444
1osvCHCBile acid receptor/0.443
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.443
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2pulACPMethylthioribose kinase2.7.1.1000.443
2w4qCBWProstaglandin reductase 21.3.1.480.443
3fmjFMJMitogen-activated protein kinase 14/0.443
3nj0PYVAbscisic acid receptor PYL2/0.443
3vtdTKDVitamin D3 receptor/0.443
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.443
4jq7KJQEpidermal growth factor receptor2.7.10.10.443
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2aibERGBeta-elicitin cinnamomin/0.442
3gggNADPrephenate dehydrogenase/0.442
3nglNAPBifunctional protein FolD/0.442
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4xoqF42Coenzyme F420:L-glutamate ligase/0.442
1o5rFR9Adenosine deaminase3.5.4.40.441
2zazGK1Mitogen-activated protein kinase 14/0.441
3fc152PMitogen-activated protein kinase 14/0.441
3slkNDPPolyketide synthase extender module 2/0.441
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.441
5iqiGNPBifunctional AAC/APH2.3.10.441
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.440
2po7CHDFerrochelatase, mitochondrial4.99.1.10.440
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.440
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.440
4ryvZEAProtein LlR18A/0.440