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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yinCM3Estrogen receptor

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1yinCM3Estrogen receptor/1.000
1sj0E4DEstrogen receptor/0.651
1xp6AIUEstrogen receptor/0.621
1errRALEstrogen receptor/0.572
2pogWSTEstrogen receptor/0.571
1uomPTIEstrogen receptor/0.569
2jf9OHTEstrogen receptor/0.534
1xqcAEJEstrogen receptor/0.513
2gpvOHTEstrogen-related receptor gamma/0.497
1yimCM4Estrogen receptor/0.492
2qe4JJ3Estrogen receptor/0.488
2fszOHTEstrogen receptor beta/0.483
2bj4OHTEstrogen receptor/0.479
2jfaRALEstrogen receptor/0.479
1qknRALEstrogen receptor beta/0.477
1ndeMONEstrogen receptor beta/0.468
4ivw1GJEstrogen receptor/0.453
2p7zOHTEstrogen-related receptor gamma/0.447
1og5SWFCytochrome P450 2C9/0.441
2z3uCRRCytochrome P450/0.441
4q73FADBifunctional protein PutA/0.441
2ewpTXFEstrogen-related receptor gamma/0.440