Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yhoTRRDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1yhoTRRDihydrofolate reductase1.5.1.31.000
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.522
4kfj1R0Dihydrofolate reductase1.5.1.30.515
3d80Q22Dihydrofolate reductase1.5.1.30.508
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.501
3p9tTCLRepressor/0.489
4kbn25UDihydrofolate reductase1.5.1.30.487
1kmsLIHDihydrofolate reductase1.5.1.30.486
3k4551PDihydrofolate reductase1.5.1.30.483
3l3rOAGDihydrofolate reductase1.5.1.30.480
4h9506UDihydrofolate reductase1.5.1.30.479
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.475
1klkPMDDihydrofolate reductase1.5.1.30.471
1pd8CO4Dihydrofolate reductase1.5.1.30.471
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
2fzjDH3Dihydrofolate reductase1.5.1.30.470
3nxvD2FDihydrofolate reductase1.5.1.30.470
4kd79DRDihydrofolate reductase1.5.1.30.468
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
3k47D09Dihydrofolate reductase1.5.1.30.467
1ohkCOPDihydrofolate reductase1.5.1.30.465
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
4jvlESTEstrogen sulfotransferase2.8.2.40.461
3gyf51PDihydrofolate reductase1.5.1.30.460
1s3vTQDDihydrofolate reductase1.5.1.30.459
3h3r14HCollagen type IV alpha-3-binding protein/0.459
4kak06UDihydrofolate reductase1.5.1.30.459
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.458
1zq5E04Aldo-keto reductase family 1 member C3/0.457
2w3mFOLDihydrofolate reductase1.5.1.30.457
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.457
3nxrD2DDihydrofolate reductase1.5.1.30.457
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
3ghvGHCDihydrofolate reductase1.5.1.30.456
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1kmvLIIDihydrofolate reductase1.5.1.30.455
1s3uTQDDihydrofolate reductase1.5.1.30.454
4iarERM5-hydroxytryptamine receptor 1B/0.454
1ohjCOPDihydrofolate reductase1.5.1.30.453
1s3wTQTDihydrofolate reductase1.5.1.30.453
3njoPYVAbscisic acid receptor PYR1/0.453
4iaq2GM5-hydroxytryptamine receptor 1B/0.453
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.451
4k9yK9YFocal adhesion kinase 12.7.10.20.450
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3ctj320Hepatocyte growth factor receptor2.7.10.10.447
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3nxtD2EDihydrofolate reductase1.5.1.30.447
3v1s0LHStrictosidine synthase4.3.3.20.447
1og5SWFCytochrome P450 2C9/0.446
3qlwN22Dihydrofolate reductase1.5.1.30.446
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
1g3mPCQEstrogen sulfotransferase2.8.2.40.445
1u72MTXDihydrofolate reductase1.5.1.30.444
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3cseN22Uncharacterized protein/0.443
3s3vTOPDihydrofolate reductase1.5.1.30.443
3n0hTOPDihydrofolate reductase1.5.1.30.442
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.441
4hni16WCasein kinase I isoform epsilon2.7.11.10.441
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3h3t16HCollagen type IV alpha-3-binding protein/0.440