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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yhnGTPRas-related protein Rab-7a

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1yhnGTPRas-related protein Rab-7a/1.000
1t91GTPRas-related protein Rab-7a/0.610
3e5hGNPRas-related protein Rab-28/0.580
3bbpGTPRas-related protein Rab-6A/0.570
2gilGTPRas-related protein Rab-6A/0.554
1vg8GNPRas-related protein Rab-7a/0.550
2ffqGSPRas-related protein Rab-6B/0.538
3tnfGNPRas-related protein Rab-8A/0.532
1yzqGNPRas-related protein Rab-6A/0.530
4o25GTPGTP-binding protein Rheb/0.529
3oesGNPGTPase RhebL1/0.513
1xtrGNPGTP-binding protein Rheb/0.498
1zbdGTPRas-related protein Rab-3A/0.498
4qxaGTPRas-related protein Rab-9A/0.483
3tsoGNPRas-related protein Rab-25/0.477
4lhwGNPRas-related protein Rab-8A/0.477
4cymGCPRas-related protein Rab-32/0.474
3nbzGTPGTP-binding nuclear protein Ran/0.472
5dhaGNPGTP-binding nuclear protein Ran/0.469
3a6pGTPGTP-binding nuclear protein Ran/0.464
3lbnGNPGTPase HRas/0.464
1xtsGTPGTP-binding protein Rheb/0.460
3ea5GDPGTP-binding nuclear protein Ran/0.460
3kz1GSPTransforming protein RhoA/0.450
1zc3GNPRas-related protein Ral-A/0.447
1cxzGSPTransforming protein RhoA/0.445
2gcpGSPRho-related GTP-binding protein RhoC/0.445
1oixGDPRas-related protein Rab-11A/0.444
1zc4GNPRas-related protein Ral-A/0.443
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.442