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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xtsGTPGTP-binding protein Rheb

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1xtsGTPGTP-binding protein Rheb/1.000
1xtrGNPGTP-binding protein Rheb/0.578
3oesGNPGTPase RhebL1/0.536
5dhaGNPGTP-binding nuclear protein Ran/0.503
1m7bGTPRho-related GTP-binding protein RhoE/0.493
4o25GTPGTP-binding protein Rheb/0.493
3rabGNPRas-related protein Rab-3A/0.492
4cymGCPRas-related protein Rab-32/0.488
1yzqGNPRas-related protein Rab-6A/0.485
2gilGTPRas-related protein Rab-6A/0.483
3e5hGNPRas-related protein Rab-28/0.483
1zbdGTPRas-related protein Rab-3A/0.477
3w3zGTPGTP-binding nuclear protein Ran/0.477
2zetGTPRas-related protein Rab-27B/0.475
1ibrGNPGTP-binding nuclear protein Ran/0.474
2fe4GDPRas-related protein Rab-6B/0.471
1kmqGNPTransforming protein RhoA/0.467
3lbnGNPGTPase HRas/0.466
3oivGNPGTPase HRas/0.465
4mitGTPRho-related protein racC/0.464
5hpyGDPTransforming protein RhoA/0.462
4qxaGTPRas-related protein Rab-9A/0.461
1cxzGSPTransforming protein RhoA/0.460
2clsGTPRho-related GTP-binding protein Rho6/0.460
4rkfGNPRas-related protein Rab-3/0.460
3kucGDPRas-related protein Rap-1A/0.458
4lhwGNPRas-related protein Rab-8A/0.458
1zc3GNPRas-related protein Ral-A/0.457
1s1cGNPTransforming protein RhoA/0.456
1zc4GNPRas-related protein Ral-A/0.455
4js0GNPCell division control protein 42 homolog/0.455
3eg5GNPCell division control protein 42 homolog/0.454
4nyiGNPGTPase HRas/0.454
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.453
3oiuGNPGTPase HRas/0.453
3tklGTPRas-related protein Rab-1A/0.453
5b2zGNPGTPase HRas/0.453
1g17GNPRas-related protein SEC4/0.452
1uadGNPRas-related protein Ral-A/0.452
2ffqGSPRas-related protein Rab-6B/0.452
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.450
4nyjGNPGTPase HRas/0.450
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.448
3tsoGNPRas-related protein Rab-25/0.448
1t91GTPRas-related protein Rab-7a/0.447
3bbpGTPRas-related protein Rab-6A/0.447
4dltGNPGTPase HRas/0.446
4kvgGTPRas-related protein Rap-1A/0.446
3kz1GSPTransforming protein RhoA/0.445
5jljGNPGTP-binding nuclear protein Ran/0.445
3ddcGNPGTPase HRas/0.443
3v4fGNPGTPase HRas/0.442
1oixGDPRas-related protein Rab-11A/0.441
3a58GNPGTP-binding protein RHO1/0.441
2gcpGSPRho-related GTP-binding protein RhoC/0.440