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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xs4DCPdCTP deaminase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1xs4DCPdCTP deaminase/1.000
2v9xDUTdCTP deaminase/0.582
3junAKDPhenazine biosynthesis protein A/B/0.539
2hxdDUPdCTP deaminase, dUMP-forming3.5.4.300.528
3juqAJDPhenazine biosynthesis protein A/B/0.517
3junAJDPhenazine biosynthesis protein A/B/0.511
3vw7VPXProteinase-activated receptor 1/0.507
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.506
4a6aTTPdCTP deaminase3.5.4.130.501
3rq8AP5ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.498
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.493
2rqfJH3Hemolymph juvenile hormone binding protein/0.492
3juqAKDPhenazine biosynthesis protein A/B/0.491
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.490
3qviK95HAP protein/0.488
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.487
3dziRGTADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.486
1f20FADNitric oxide synthase, brain1.14.13.390.485
2zbaZBATrichothecene 3-O-acetyltransferase/0.485
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.485
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.484
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.484
4x5hFOLDihydrofolate reductase1.5.1.30.483
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.482
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.482
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.481
4l4xNDPAmphI/0.481
2ab8MTPAdenosine kinase2.7.1.200.480
3bnkFMNFlavoredoxin/0.480
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.480
4m4922YL-lactate dehydrogenase A chain1.1.1.270.479
1txtCAAHMG-CoA synthase/0.478
1w4xFADPhenylacetone monooxygenase1.14.13.920.478
4dfg0JVGag-Pol polyprotein3.4.23.160.478
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.478
3e5hGNPRas-related protein Rab-28/0.477
3h0bB35Beta-secretase 13.4.23.460.476
4fxy0W2Neurolysin, mitochondrial3.4.24.160.476
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.475
4eph0RKCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.475
3h3r14HCollagen type IV alpha-3-binding protein/0.474
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.473
2iyfERYOleandomycin glycosyltransferase2.4.10.473
3rdiCMPcAMP-activated global transcriptional regulator CRP/0.473
1culFOKAdenylate cyclase type 2/0.472
1culFOKAdenylate cyclase type 5/0.472
1q6yCOAFormyl-CoA:oxalate CoA-transferase/0.472
2dxiATPGlutamate--tRNA ligase6.1.1.170.472
2fj1CTCTetracycline repressor protein class D/0.472
2xtnGTPGTPase IMAP family member 2/0.472
4i1nFOLDihydrofolate reductase1.5.1.30.472
1vgrCOAFormyl-CoA:oxalate CoA-transferase/0.471
4gsuDWZL,D-transpeptidase 22.3.20.471
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.471
1udaUFGUDP-glucose 4-epimerase5.1.3.20.470
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.470
2cbrA80Cellular retinoic acid-binding protein 1/0.470
2dxvSAHDiphthine synthase/0.470
2os1BB2Peptide deformylase/0.470
2we3DUTDeoxyuridine 5'-triphosphate nucleotidohydrolase/0.470
3fkqATPNtrC-like two-domain protein/0.470
5cyoGDPSeptin-9/0.470
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.470
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.469
1j78VDYVitamin D-binding protein/0.469
1u71MXADihydrofolate reductase1.5.1.30.469
3ekuCY9Actin-5C/0.469
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.469
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.469
1m0b0ZQGag-Pol polyprotein3.4.23.160.468
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.468
3m2rCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.468
3m2rCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.468
3tog079Gag-Pol polyprotein2.7.7.490.468
2c20NADUDP-glucose 4-epimerase/0.467
2ien017Gag-Pol polyprotein3.4.23.160.467
3opxU5PSuppressor of disruption of TFIIS/0.467
4rtbSAMPutative thiazole biosynthesis protein ThiH/0.467
4y35F90Endothiapepsin3.4.23.220.467
1mjbACOHistone acetyltransferase ESA1/0.466
1vf2GTXGlutathione S-transferase 32.5.1.180.466
2ek3SAHDiphthine synthase/0.466
2vq7NAPPutative flavin-containing monooxygenase/0.466
3nzpPLPArginine decarboxylase/0.466
4jc51K5Stimulator of interferon genes protein/0.466
4lhvGDPRas-related protein Rab-8A/0.466
4wrkDUPDUTPase/0.466
1vyqDUXDeoxyuridine 5'-triphosphate nucleotidohydrolase/0.465
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.465
2bxmIMNSerum albumin/0.465
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.465
2oapANPType II secretion system protein (GspE-2)/0.465
3b05IPEIsopentenyl-diphosphate delta-isomerase/0.465
3i0pNADMalate dehydrogenase, putative/0.465
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.465
3toh079Gag-Pol polyprotein2.7.7.490.465
4bjcRPBTankyrase-22.4.2.300.465
4exg916Beta-secretase 13.4.23.460.465
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.464
1p0pBCHCholinesterase3.1.1.80.464
1pq944BOxysterols receptor LXR-beta/0.464
1yw8A75Methionine aminopeptidase 2/0.464
2ejzSAHDiphthine synthase/0.464
3d2mCOAAmino-acid acetyltransferase/0.464
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.464
3rzpPRFNADPH-dependent 7-cyano-7-deazaguanine reductase/0.464
3tn8F18Cyclin-dependent kinase 92.7.11.220.464
4g95OAGDihydrofolate reductase1.5.1.30.464
4ke11R6Beta-secretase 13.4.23.460.464
4kgnSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.464
5a0yCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.464
5a0yCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.464
1mvtDTMDihydrofolate reductase1.5.1.30.463
1p0ySAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.463
2bxqIMNSerum albumin/0.463
2eglSAHDiphthine synthase/0.463
2j4qTTPdCTP deaminase/0.463
2ofiADK3-methyladenine DNA glycosylase I/0.463
2p5cSAHDiphthine synthase/0.463
3v3qTMYNuclear receptor subfamily 4 group A member 1/0.463
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.463
4fse0VABeta-secretase 13.4.23.460.463
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.463
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.462
1qy8RDIEndoplasmin/0.462
1vi2NADQuinate/shikimate dehydrogenase/0.462
1x1cSAHC-20 methyltransferase/0.462
2a9y26AAdenosine kinase2.7.1.200.462
2dxwSAHDiphthine synthase/0.462
3zeiAWHO-acetylserine sulfhydrylase/0.462
1hbvGANGag-Pol polyprotein/0.461
1z2nADPInositol-tetrakisphosphate 1-kinase2.7.1.1340.461
2en5SAHDiphthine synthase/0.461
2g1n1IGRenin3.4.23.150.461
3bk2U5PRibonuclease J/0.461
3rqqBA3ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.461
4dptAGSMevalonate diphosphate decarboxylase/0.461
4u0mATPCyclic GMP-AMP synthase/0.461
1fxfMJIPhospholipase A2, major isoenzyme3.1.1.40.460
1uumFMNDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.460
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.460
2vj9VG7Beta-secretase 13.4.23.460.460
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.460
3r4b74TGag-Pol polyprotein/0.460
4l0oPLPCystathionine gamma-synthase2.5.1.480.460
2a1oCAMCamphor 5-monooxygenase1.14.15.10.459
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.459
2cjfRP43-dehydroquinate dehydratase4.2.1.100.459
2dekSAHDiphthine synthase/0.459
2gtbAZPOrf1ab polyprotein/0.459
3c14FOKAdenylate cyclase type 2/0.459
3c14FOKAdenylate cyclase type 5/0.459
3rqhB6PADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.459
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.459
4a86H35Major pollen allergen Bet v 1-A/0.459
4bgg844Activin receptor type-12.7.11.300.459
4cf7ADPAdenylate kinase/0.459
4dd8BATDisintegrin and metalloproteinase domain-containing protein 83.4.240.459
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.458
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.458
2cv1ATPGlutamate--tRNA ligase6.1.1.170.458
2e16SAHDiphthine synthase/0.458
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.458
2pchSAHDiphthine synthase/0.458
2zrjAGSProtein RecA/0.458
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.458
3rthRTHBeta-secretase 13.4.23.460.458
4dz2FK5Peptidyl-prolyl cis-trans isomerase/0.458
4k28NADShikimate dehydrogenase family protein/0.458
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.458
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.458
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.457
1jqiCAAShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.457
1mrqSTRAldo-keto reductase family 1 member C1/0.457
1nzdUPGDNA beta-glucosyltransferase/0.457
1pd9CO4Dihydrofolate reductase1.5.1.30.457
1y6oMJIPhospholipase A2, major isoenzyme3.1.1.40.457
2c29NAPDihydroflavonol 4-reductase/0.457
2ek2SAHDiphthine synthase/0.457
2oegUPGUDP-glucose pyrophosphorylase/0.457
3dc3AZMCarbonic anhydrase 24.2.1.10.457
3fsjD7KBenzoylformate decarboxylase4.1.1.70.457
3h2sNDPPutative NADH-flavin reductase/0.457
3imgBZ3Pantothenate synthetase6.3.2.10.457
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.457
3ohh3HHBeta-secretase 13.4.23.460.457
3p82FMNPentaerythritol tetranitrate reductase/0.457
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.457
4a862ANMajor pollen allergen Bet v 1-A/0.457
4blrUTPNTPase P4/0.457
4df2FMNNADPH dehydrogenase/0.457
4ef4C2EStimulator of interferon genes protein/0.457
4gn8ASORegucalcin3.1.1.170.457
4twnB96Ephrin type-A receptor 32.7.10.10.457
4zwpM44Xaa-Pro dipeptidase3.4.13.90.457
5dp2NAPCurF/0.457
1dfoPLGSerine hydroxymethyltransferase2.1.2.10.456
1drhNAPDihydrofolate reductase1.5.1.30.456
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.456
1vceSAHDiphthine synthase/0.456
1w13SM1Urokinase-type plasminogen activator3.4.21.730.456
2a94AP0L-lactate dehydrogenase1.1.1.270.456
2dv7SAHDiphthine synthase/0.456
2ffqGSPRas-related protein Rab-6B/0.456
2w9hTOPDihydrofolate reductase1.5.1.30.456
2ym1FADPhenylacetone monooxygenase1.14.13.920.456
3cluFADElectron transfer flavoprotein subunit alpha/0.456
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.456
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.456
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.456
3t4eNADQuinate/shikimate dehydrogenase/0.456
4l4eCAMCamphor 5-monooxygenase1.14.15.10.456
4nbwNADShort-chain dehydrogenase/reductase SDR/0.456
4oztP1AEcdysone receptor, putative/0.456
5fsi8DG7,8-dihydro-8-oxoguanine triphosphatase3.6.1.550.456
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
1dliUDXUDP-glucose 6-dehydrogenase/0.455
1mv8GDXGDP-mannose 6-dehydrogenase1.1.1.1320.455
1pf7IMHPurine nucleoside phosphorylase2.4.2.10.455
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.455
2ek7SAHDiphthine synthase/0.455
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
3e39FMNNitroreductase/0.455
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.455
4rnwFMNNADPH dehydrogenase 11.6.99.10.455
1f0yNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.454
1kqfMGDFormate dehydrogenase, nitrate-inducible, major subunit1.1.5.60.454
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.454
1tqf32PBeta-secretase 13.4.23.460.454
1w6hTITPlasmepsin-23.4.23.390.454
2b53D23Cyclin-dependent kinase 22.7.11.220.454
2b58COADiamine acetyltransferase 1/0.454
2dv4SAHDiphthine synthase/0.454
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.454
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.454
2xb9XNW3-dehydroquinate dehydratase4.2.1.100.454
3aosJH2Hemolymph juvenile hormone binding protein/0.454
3b1dPLSBetaC-S lyase/0.454
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.454
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.454
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.454
3rsv3RSBeta-secretase 13.4.23.460.454
3sl2ATPSensor histidine kinase WalK/0.454
3u9eCOALmo1369 protein/0.454
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.454
4idpGNPAtlastin-13.6.50.454
4opiFDAConserved Archaeal protein/0.454
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1rpnNDPGDP-mannose 4,6-dehydratase/0.453
2el0SAHDiphthine synthase/0.453
2jibADPOxalyl-CoA decarboxylase4.1.1.80.453
2npxNADNADH peroxidase1.11.1.10.453
2p6iSAHDiphthine synthase/0.453
2p6lSAHDiphthine synthase/0.453
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.453
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.453
2zshGA3Gibberellin receptor GID1A30.453
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.453
3lzs017Gag-Pol polyprotein3.4.23.160.453
4an4DUDPutative glycosyl transferase/0.453
4bf9FMNtRNA-dihydrouridine(16) synthase/0.453
4m6jNDPDihydrofolate reductase1.5.1.30.453
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.453
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.453
1aj22PHDihydropteroate synthase/0.452
1il0NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
1nvmNADAcetaldehyde dehydrogenase1.2.1.100.452
1qf5RPLAdenylosuccinate synthetase/0.452
1zrzBI1Protein kinase C iota type2.7.11.130.452
2dv3SAHDiphthine synthase/0.452
2e8qSAHDiphthine synthase/0.452
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.452
2fr1NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.452
2p8hMY9Beta-secretase 13.4.23.460.452
3a0tADPSensor histidine kinase/0.452
3gy9COAGCN5-related N-acetyltransferase/0.452
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.452
3qizQI2Botulinum neurotoxin type A3.4.24.690.452
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.452
4loi1YCStimulator of interferon genes protein/0.452
4uocNCNCinA-like protein/0.452
4xvuATPATPase GET3/0.452
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.451
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.451
1rf7DHFDihydrofolate reductase1.5.1.30.451
1t3zCAOFormyl-CoA:oxalate CoA-transferase/0.451
1xddAAYIntegrin alpha-L/0.451
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.451
2emuSAHDiphthine synthase/0.451
2owvSAHDiphthine synthase/0.451
2rlcCHDCholoylglycine hydrolase3.5.1.240.451
2xtkAZMClass III chitinase ChiA1/0.451
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.451
3h3t16HCollagen type IV alpha-3-binding protein/0.451
3upf0BUPolyprotein/0.451
3uxvGUNNADPH-dependent 7-cyano-7-deazaguanine reductase/0.451
4b4w9L9Bifunctional protein FolD/0.451
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.451
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.451
4ycpFMNtRNA-dihydrouridine(16) synthase/0.451
5fwnNAPPutative dehydrogenase/0.451
1b8nIMGPurine nucleoside phosphorylase2.4.2.10.450
1diuBDMDihydrofolate reductase1.5.1.30.450
1esvLARActin, alpha skeletal muscle/0.450
1n3rGTPGTP cyclohydrolase 13.5.4.160.450
2bjfDXCCholoylglycine hydrolase3.5.1.240.450
2oahQINBeta-secretase 13.4.23.460.450
2qbmCAMCamphor 5-monooxygenase1.14.15.10.450
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
2zvbSAHPrecorrin-3 C17-methyltransferase/0.450
3i25MV7Beta-secretase 13.4.23.460.450
3pwm017Gag-Pol polyprotein3.4.23.160.450
4a6cQG9Gag-Pol polyprotein3.4.23.160.450
4c72TLG3-oxoacyl-ACP synthase/0.450
4dfrMTXDihydrofolate reductase1.5.1.30.450
4fdaNAP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.450
4nmdFDABifunctional protein PutA/0.450
4nv10FXFormyl transferase/0.450
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.450
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1u1gBBBUridine phosphorylase2.4.2.30.449
1w1wAGSStructural maintenance of chromosomes protein 1/0.449
1xvaSAMGlycine N-methyltransferase2.1.1.200.449
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.449
2abjPLPBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.449
2amt1AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.449
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.449
2bglNAJSecoisolariciresinol dehydrogenase1.1.1.3310.449
2cchATPCyclin-dependent kinase 22.7.11.220.449
2f3rG5PGuanylate kinase2.7.4.80.449
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.449
2pb4SAHDiphthine synthase/0.449
2pcaSAHDiphthine synthase/0.449
2qxxTTPdCTP deaminase3.5.4.130.449
3dzkNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.449
3fwyADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein/0.449
3keqNADRedox-sensing transcriptional repressor Rex/0.449
3ppr4CSGlycine betaine/carnitine/choline-binding protein OpuCC/0.449
3qvsNADMyo-inositol-1-phosphate synthase (Ino1)/0.449
4b1uLABActin, alpha skeletal muscle/0.449
4dpy2P0Mevalonate diphosphate decarboxylase/0.449
4egh0OYHeat shock protein HSP 90-alpha/0.449
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
4l1fCOSAcyl-CoA dehydrogenase domain protein/0.449
4m83ERYOleandomycin glycosyltransferase2.4.10.449
4pb25UDNucleoside permease/0.449
5kl9COAAcyl-CoA thioester hydrolase YbgC3.1.20.449
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.448
1nhtPGSAdenylosuccinate synthetase/0.448
1p4aPCPPur operon repressor/0.448
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.448
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.448
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.448
1w4lGL8Acetylcholinesterase3.1.1.70.448
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.448
2af3COAPhosphate acetyltransferase2.3.1.80.448
2e0nSAHPrecorrin-2 C20-methyltransferase/0.448
2e1mFADL-glutamate oxidase/0.448
2emrSAHDiphthine synthase/0.448
2j2pSC2Ficolin-2/0.448
2pb6SAHDiphthine synthase/0.448
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.448
2z54AB1Gag-Pol polyprotein3.4.23.160.448
3eksCY9Actin-5C/0.448
3lqfNADGalactitol dehydrogenase/0.448
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.448
3mvm39PMitogen-activated protein kinase 14/0.448
3nb5R21Carbonic anhydrase 24.2.1.10.448
3phiNDPShikimate dehydrogenase (NADP(+))/0.448
3pvcFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.448
4e03ADPPlasmid partitioning protein ParF/0.448
4e2dFMNDehydrogenase/0.448
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.448
5dw50T1Succinyl-CoA:acetate CoA-transferase/0.448
1drfFOLDihydrofolate reductase1.5.1.30.447
1h65GDPTranslocase of chloroplast 343.6.50.447
1ra8FOLDihydrofolate reductase1.5.1.30.447
1rszDIHPurine nucleoside phosphorylase2.4.2.10.447
1rx8FOLDihydrofolate reductase1.5.1.30.447
1vikBAYGag-Pol polyprotein/0.447
2c27ACOMycothiol acetyltransferase2.3.1.1890.447
2djxFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.447
2f81017Gag-Pol polyprotein3.4.23.160.447
2g94ZPQBeta-secretase 13.4.23.460.447
2huxSAHDiphthine synthase/0.447
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.447
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.447
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3fhxPXLPyridoxal kinase2.7.1.350.447
3hlwCE3Beta-lactamase/0.447
3k5fAYHBeta-secretase 13.4.23.460.447
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.447
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.447
3p0hFSEPutative tyrosyl-tRNA synthetase/0.447
3uayADNPurine nucleoside phosphorylase DeoD-type/0.447
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.447
4du82P0Mevalonate diphosphate decarboxylase/0.447
4dus0MPBeta-secretase 13.4.23.460.447
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.447
4l4fCAMCamphor 5-monooxygenase1.14.15.10.447
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.447
1a72PADAlcohol dehydrogenase E chain1.1.1.10.446
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.446
1g54FFBCarbonic anhydrase 24.2.1.10.446
1h60STRPentaerythritol tetranitrate reductase/0.446
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.446
1juvNDPDihydrofolate reductase1.5.1.30.446
1mvsDTMDihydrofolate reductase1.5.1.30.446
1ra3MTXDihydrofolate reductase1.5.1.30.446
1ykdCMPAdenylate cyclase/0.446
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.446
2d2iNAPGlyceraldehyde-3-phosphate dehydrogenase/0.446
2hsaFMN12-oxophytodienoate reductase 31.3.1.420.446
3c27DKKProthrombin3.4.21.50.446
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.446
3p67FMNPentaerythritol tetranitrate reductase/0.446
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4opgFDAConserved Archaeal protein/0.446
4ttcFMNIodotyrosine deiodinase 1/0.446
4wxfPLGSerine hydroxymethyltransferase/0.446
4x3lMTARNA 2'-O ribose methyltransferase/0.446
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.445
1mjaCOAHistone acetyltransferase ESA1/0.445
1pjcNADAlanine dehydrogenase/0.445
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.445
1u0yPA7Endoplasmin/0.445
1u28NAPNAD(P) transhydrogenase subunit beta1.6.1.20.445
1v453DGPurine nucleoside phosphorylase2.4.2.10.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
2freFMNNAD(P)H-flavin oxidoreductase/0.445
2g1o2IGRenin3.4.23.150.445
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.445
2qfoA13Heat shock protein HSP 90-alpha/0.445
2w6mOA1Biotin carboxylase6.3.4.140.445
2y3pSM8DNA gyrase subunit A/0.445
3daaPDDD-alanine aminotransferase2.6.1.210.445
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
3ggj25HHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.445
3gh8FMNIodotyrosine deiodinase 11.21.1.10.445
3k8q22APurine nucleoside phosphorylase2.4.2.10.445
3o7bSAHRibosomal RNA small subunit methyltransferase Nep1/0.445
3qvrFADGlucose oxidase1.1.3.40.445
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.445
3v0p4GWHisto-blood group ABO system transferase/0.445
3zgl10E4-hydroxy-3-methylbut-2-enyl diphosphate reductase/0.445
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.445
4a6nFADTetX family tetracycline inactivation enzyme/0.445
4f9gC2EStimulator of interferon genes protein/0.445
4iqqUMPThymidylate synthase/0.445
5c3jUQ1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.445
5c3jUQ1Succinate dehydrogenase cytochrome b560/0.445
5cc9DDFDihydrofolate reductase1.5.1.30.445
1kh3ANPArgininosuccinate synthase/0.444
1kvuUPGUDP-glucose 4-epimerase5.1.3.20.444
1s14NOVDNA topoisomerase 4 subunit B/0.444
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.444
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.444
2ed3SAHDiphthine synthase/0.444
2pcmSAHDiphthine synthase/0.444
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.444
2w6qOA5Biotin carboxylase6.3.4.140.444
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.444
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.444
3b9lAZZSerum albumin/0.444
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3gwdFADCyclohexanone monooxygenase/0.444
3nmpPYVAbscisic acid receptor PYL2/0.444
3own3OXRenin3.4.23.150.444
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.444
3w8eNAD3-hydroxybutyrate dehydrogenase/0.444
3wb2YGPUncharacterized protein MJ0488/0.444
4cukNAID-lactate dehydrogenase/0.444
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.444
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.444
4iraFAD4-hydroxyphenylacetate 3-monooxygenase/0.444
4tmcFMNOld yellow enzyme/0.444
4xboSAHtRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ2.1.1.2000.444
5fkmTDCTetracycline repressor protein class D/0.444
1bwlFMNNADPH dehydrogenase 11.6.99.10.443
1dhfFOLDihydrofolate reductase1.5.1.30.443
1eveE20Acetylcholinesterase3.1.1.70.443
1kmyBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.443
1n06ADPRiboflavin kinase2.7.1.260.443
1u0hFOKAdenylate cyclase type 2/0.443
1u0hFOKAdenylate cyclase type 5/0.443
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.443
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.443
1wur8DGGTP cyclohydrolase 1/0.443
1xjjDGTVitamin B12-dependent ribonucleotide reductase/0.443
2b7aIZATyrosine-protein kinase JAK2/0.443
2e07SAHDiphthine synthase/0.443
2ejkSAHDiphthine synthase/0.443
2erzHFScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2pj4414Carboxypeptidase B/0.443
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.443
2qenADPWalker-Type ATPase/0.443
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.443
2vigCOSShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.443
2w3bNDPDihydrofolate reductase1.5.1.30.443
3a6qFMNFMN-binding protein/0.443
3fp0FP015-O-acetyltransferase/0.443
3fr5I4AFatty acid-binding protein, adipocyte/0.443
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3in6FMNUncharacterized protein/0.443
3iphG11Mitogen-activated protein kinase 14/0.443
3ppoDCKGlycine betaine/carnitine/choline-binding protein OpuCC/0.443
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.443
3wleNAD(R)-specific carbonyl reductase/0.443
4ck2NVUIntegrase/0.443
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.443
4lcjNADC-terminal-binding protein 2/0.443
4nh0ATPESX secretion system protein EccC/0.443
4q0kGA3Phytohormone-binding protein/0.443
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.443
1dr5NAPDihydrofolate reductase1.5.1.30.442
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.442
1jmhUMPThymidylate synthase/0.442
1m78NDPDihydrofolate reductase1.5.1.30.442
1sbrVIBPutative HMP/thiamine-binding protein YkoF/0.442
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1xl5190Gag-Pol polyprotein3.4.23.160.442
1xz85GPBifunctional protein PyrR2.4.2.90.442
2g97DGBNicotinamide phosphoribosyltransferase2.4.2.120.442
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
2i7pACOPantothenate kinase 32.7.1.330.442
2io7ANPBifunctional glutathionylspermidine synthetase/amidase/0.442
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.442
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.442
2os3BB2Peptide deformylase/0.442
2owuSAHDiphthine synthase/0.442
2p6dSAHDiphthine synthase/0.442
2qfoA51Heat shock protein HSP 90-alpha/0.442
2r26CMCCitrate synthase2.3.3.160.442
2rc4ACOHistone acetyltransferase KAT6A/0.442
2v16C47Renin3.4.23.150.442
2vkvTDCTetracycline repressor protein class D/0.442
2ylzFADPhenylacetone monooxygenase1.14.13.920.442
2ztsADPUncharacterized protein/0.442
3c6n2S8Protein TRANSPORT INHIBITOR RESPONSE 1/0.442
3cvuFADRE11660p/0.442
3gkaFMNN-ethylmaleimide reductase/0.442
3h3qH13Collagen type IV alpha-3-binding protein/0.442
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.442
3t82SG4Carbonic anhydrase 24.2.1.10.442
3vdqNAD3-hydroxybutyrate dehydrogenase/0.442
4bfzZVZPantothenate kinase2.7.1.330.442
4cghLOZIntegrase/0.442
4db1ANPMyosin-7/0.442
4dpi0N1Beta-secretase 13.4.23.460.442
4fm80UQBeta-secretase 13.4.23.460.442
4hj6FMNLOV protein/0.442
4yj2GTPTubulin alpha-1B chain/0.442
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5ex0SAHHistone-lysine N-methyltransferase SMYD32.1.1.430.442
1cnfFADNitrate reductase [NADH]1.7.1.10.441
1kfbIGPTryptophan synthase alpha chain/0.441
1rftPXMPyridoxal kinase2.7.1.350.441
1touB1VFatty acid-binding protein, adipocyte/0.441
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.441
2egbSAHDiphthine synthase/0.441
2ojg19AMitogen-activated protein kinase 12.7.11.240.441
2oo7AP5Adenylate kinase/0.441
2p4sDIHAGAP005945-PA/0.441
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.441
2qn3F55Glycogen phosphorylase, muscle form2.4.1.10.441
2wzwNDPNitroreductase NfnB/0.441
2xhd7T9Glutamate receptor 2/0.441
3c15FOKAdenylate cyclase type 2/0.441
3c15FOKAdenylate cyclase type 5/0.441
3clsFADElectron transfer flavoprotein subunit alpha/0.441
3gyaCOAGCN5-related N-acetyltransferase/0.441
3ipkPMSSurface protein adhesin/0.441
3l06SN0N-acetylornithine carbamoyltransferase2.1.3.90.441
3lcjCOAPhosphopantetheine adenylyltransferase/0.441
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.441
3mtfA3FActivin receptor type-12.7.11.300.441
3nxxNDPDihydrofolate reductase1.5.1.30.441
3pmy41LEndothiapepsin3.4.23.220.441
3r0iC0K1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.441
3rh7FMNUncharacterized protein/0.441
3rpeFADPutative modulator of drug activity/0.441
3t84SG6Carbonic anhydrase 24.2.1.10.441
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.441
4baoMVFProthrombin3.4.21.50.441
4c04SFGProtein arginine N-methyltransferase 6/0.441
4de10J6Beta-lactamase/0.441
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.441
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.441
4i8zG08Gag-Pol polyprotein3.4.23.160.441
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.441
4kouC04Uncharacterized protein/0.441
4lxb7R9Prothrombin3.4.21.50.441
4x9nFADUncharacterized protein MG039 homolog/0.441
5bnw12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.441
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.440
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.440
1mmkH4BPhenylalanine-4-hydroxylase1.14.16.10.440
1njfADPDNA polymerase III subunit tau2.7.7.70.440
1snfUMPDeoxyuridine 5'-triphosphate nucleotidohydrolase3.6.1.230.440
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.440
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.440
2e15SAHDiphthine synthase/0.440
2e4nSAHDiphthine synthase/0.440
2e8hSAHDiphthine synthase/0.440
2fznFADBifunctional protein PutA1.5.5.20.440
2jgsBTNAvidin/0.440
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.440
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.440
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.440
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.440
2rh9IGPTryptophan synthase alpha chain/0.440
3b9xNOSPyrimidine-specific ribonucleoside hydrolase RihB3.2.2.80.440
3fhxPLPPyridoxal kinase2.7.1.350.440
3kemIPE4-hydroxy-3-methylbut-2-enyl diphosphate reductase/0.440
3lpjZ75Beta-secretase 13.4.23.460.440
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.440
3pl8FADPyranose 2-oxidase/0.440
3sfuRBVPolyprotein/0.440
3t7p7SPEndothiapepsin3.4.23.220.440
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.440
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.440
4fhd0TTSpore photoproduct lyase/0.440
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
4i13FOLDihydrofolate reductase1.5.1.30.440
4iva1J5Tyrosine-protein kinase JAK2/0.440
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.440
4pk4ADPUnconventional myosin-VI/0.440
4pleCPSNuclear receptor subfamily 5 group A member 2/0.440
4qaiFMNNADPH dehydrogenase/0.440
4xrbNDPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.440
5a1tNAIL-lactate dehydrogenase/0.440
5d3qGDPDynamin-13.6.5.50.440
5e6yACX1,4-alpha-glucan branching enzyme GlgB/0.440