sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1xry | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1xry | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 | 1.000 | |
| 1txr | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 | 0.738 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.507 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.507 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.506 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.500 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.492 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.486 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.485 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.485 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 2pak | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.484 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.484 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.480 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.480 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.479 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.479 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.478 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.477 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.477 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.476 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.476 | |
| 1ngs | TPP | Transketolase 1 | 2.2.1.1 | 0.474 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.474 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.473 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.472 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.472 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.471 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.471 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.470 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.470 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.470 | |
| 3e8x | NAP | BH1520 protein | / | 0.470 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.470 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.469 | |
| 4j7h | TRH | PCZA361.3 | / | 0.469 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.468 | |
| 3bnk | FMN | Flavoredoxin | / | 0.468 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.468 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.467 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.467 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.466 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.466 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.464 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.464 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.464 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.464 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3b4p | 3B4 | Phenazine biosynthesis protein A/B | / | 0.463 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.463 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.462 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.462 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.462 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.462 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.461 | |
| 1ye6 | NAP | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.461 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.461 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.461 | |
| 4a5s | N7F | Dipeptidyl peptidase 4 | / | 0.461 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.460 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 3fuj | 00G | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.460 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.460 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.459 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.459 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.459 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.459 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.459 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.458 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1req | DCA | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.458 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.458 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.458 | |
| 3g0d | XIH | Dipeptidyl peptidase 4 | / | 0.458 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.458 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 3zgf | IUG | Histo-blood group ABO system transferase | / | 0.458 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.458 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.457 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.457 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.457 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.457 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.457 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.457 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.457 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.456 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.456 | |
| 2d81 | RB3 | Poly(3-hydroxybutyrate) depolymerase | / | 0.456 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.456 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.456 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.456 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.456 | |
| 3ukf | GDU | UDP-galactopyranose mutase | / | 0.456 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.456 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.455 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.455 | |
| 1xxj | UNC | Uricase | 1.7.3.3 | 0.455 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3c1o | NAP | Eugenol synthase | / | 0.455 | |
| 3c6p | 2S3 | Protein TRANSPORT INHIBITOR RESPONSE 1 | / | 0.455 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.455 | |
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.455 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.455 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.455 | |
| 5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.455 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.454 | |
| 1vft | DCS | Alanine racemase | / | 0.454 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3tyc | XHP | Dihydropteroate synthase | / | 0.454 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.454 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.453 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.453 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.453 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.453 | |
| 2oad | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.453 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.453 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.453 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.453 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.452 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.452 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.452 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.452 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.452 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.451 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.451 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.451 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.451 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.451 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.451 | |
| 3fuf | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.451 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.451 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.451 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.451 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.450 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.450 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.450 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 3opm | LUI | Dipeptidyl peptidase 4 | / | 0.450 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.450 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.449 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.449 | |
| 1nj6 | A5A | Proline--tRNA ligase | / | 0.449 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.449 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 2e07 | SAH | Diphthine synthase | / | 0.449 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.449 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.449 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.448 | |
| 2dsh | SAH | Diphthine synthase | / | 0.448 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.448 | |
| 2o3u | NGD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.448 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.448 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.448 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.448 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4boe | CLR | Japanin | / | 0.448 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.447 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.447 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.447 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3g0c | RUF | Dipeptidyl peptidase 4 | / | 0.447 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3ppr | 4CS | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.447 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.447 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.447 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.447 | |
| 4e2b | FMN | Dehydrogenase | / | 0.447 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.446 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.446 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.446 | |
| 1xh8 | R55 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3mo0 | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.446 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.446 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.446 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.446 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.446 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.446 | |
| 4gcm | NAP | Thioredoxin reductase | 1.8.1.9 | 0.446 | |
| 4kot | CE3 | Uncharacterized protein | / | 0.446 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.445 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.445 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2nli | FMN | Lactate oxidase | / | 0.445 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.445 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.445 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.445 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.445 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.445 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.445 | |
| 3upt | TPP | Transketolase | / | 0.445 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.445 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.445 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 4lxl | PD2 | Lysine-specific demethylase 4B | 1.14.11 | 0.445 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.445 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.445 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.444 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.444 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3afh | GSU | Glutamate--tRNA ligase 2 | / | 0.444 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.444 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.444 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.444 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.444 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.444 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.443 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1rxj | BNI | Streptavidin | / | 0.443 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.443 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.443 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.443 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.443 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.443 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.443 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.443 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.443 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 3iaa | TYD | CalG2 | / | 0.443 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.443 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.443 | |
| 4js1 | CTN | Beta-galactoside alpha-2,6-sialyltransferase 1 | 2.4.99.1 | 0.443 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.443 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.442 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.442 | |
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.442 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.442 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.442 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.442 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.442 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.442 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.442 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.442 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.442 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.442 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.442 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.442 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 4qnw | FMN | Chanoclavine-I aldehyde reductase easA | / | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.441 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.441 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.441 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.441 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.441 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.441 | |
| 3u9y | 09L | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4drn | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.441 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.441 | |
| 4rrb | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.441 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.440 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.440 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3cw9 | 01A | 4-chlorobenzoyl CoA ligase | / | 0.440 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3hnz | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.440 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.440 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.440 | |
| 4xmx | BES | Aminopeptidase N | 3.4.11.2 | 0.440 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.440 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.440 |