sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1xrp	PRO_LEU_GLY_GLY	Proline iminopeptidase	3.4.11.5

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1xrp	PRO_LEU_GLY_GLY	Proline iminopeptidase	3.4.11.5	1.000
2v16	C47	Renin	3.4.23.15	0.459
1sve	I01	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.455
1lf2	R37	Plasmepsin-2	3.4.23.39	0.453
4a86	H35	Major pollen allergen Bet v 1-A	/	0.452
3oqk	S52	Renin	3.4.23.15	0.451
4a80	2AN	Major pollen allergen Bet v 1-A	/	0.449
2j2p	SC2	Ficolin-2	/	0.448
1w6h	TIT	Plasmepsin-2	3.4.23.39	0.444
3own	3OW	Renin	3.4.23.15	0.443
4ozt	P1A	Ecdysone receptor, putative	/	0.440