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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xpz4TZCarbonic anhydrase 24.2.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1xpz4TZCarbonic anhydrase 24.2.1.11.000
1ttm667Carbonic anhydrase 24.2.1.10.674
1a42BZUCarbonic anhydrase 24.2.1.10.619
2h15B19Carbonic anhydrase 24.2.1.10.607
1if6FBUCarbonic anhydrase 24.2.1.10.604
1bnnAL1Carbonic anhydrase 24.2.1.10.602
3k2fNKXCarbonic anhydrase 24.2.1.10.587
1bn1AL5Carbonic anhydrase 24.2.1.10.578
4kniE1ECarbonic anhydrase 24.2.1.10.576
3b4fTUOCarbonic anhydrase 24.2.1.10.573
3d8wD8WCarbonic anhydrase 24.2.1.10.573
3dazMZMCarbonic anhydrase 24.2.1.10.569
1bn3AL6Carbonic anhydrase 24.2.1.10.568
2eu3FF3Carbonic anhydrase 24.2.1.10.566
3hkuTORCarbonic anhydrase 24.2.1.10.566
3v2jAZMCarbonic anhydrase 24.2.1.10.564
3dcsMZMCarbonic anhydrase 24.2.1.10.562
1bn4AL9Carbonic anhydrase 24.2.1.10.561
3eft3BSCarbonic anhydrase 24.2.1.10.561
3dc3AZMCarbonic anhydrase 24.2.1.10.559
1i91INQCarbonic anhydrase 24.2.1.10.557
1zsbAZMCarbonic anhydrase 24.2.1.10.557
4pxxCHDCarbonic anhydrase 24.2.1.10.557
1i8zINLCarbonic anhydrase 24.2.1.10.556
1xq04TRCarbonic anhydrase 24.2.1.10.554
2weoFBWCarbonic anhydrase 24.2.1.10.554
4n16CHDCarbonic anhydrase 24.2.1.10.554
3ffpLC1Carbonic anhydrase 24.2.1.10.553
3sbhE65Carbonic anhydrase 24.2.1.10.553
1kwrSG2Carbonic anhydrase 24.2.1.10.551
3po6DT9Carbonic anhydrase 24.2.1.10.550
3ni5C1HCarbonic anhydrase 24.2.1.10.549
2wd2MS5Carbonic anhydrase 24.2.1.10.547
3d9zD9ZCarbonic anhydrase 24.2.1.10.547
3m5eJDRCarbonic anhydrase 24.2.1.10.547
1i90INMCarbonic anhydrase 24.2.1.10.546
3nb5R21Carbonic anhydrase 24.2.1.10.543
1g52F2BCarbonic anhydrase 24.2.1.10.542
3mhlJ71Carbonic anhydrase 24.2.1.10.541
1if4FBSCarbonic anhydrase 24.2.1.10.540
3m2yBE0Carbonic anhydrase 24.2.1.10.540
1cnwEG1Carbonic anhydrase 24.2.1.10.537
1bnwTPDCarbonic anhydrase 24.2.1.10.534
1g1dFSBCarbonic anhydrase 24.2.1.10.534
3saxE50Carbonic anhydrase 24.2.1.10.533
1bnuAL3Carbonic anhydrase 24.2.1.10.532
2x7tWZBCarbonic anhydrase 24.2.1.10.532
3t82SG4Carbonic anhydrase 24.2.1.10.532
1bnqAL4Carbonic anhydrase 24.2.1.10.531
1g4jFFBCarbonic anhydrase 24.2.1.10.531
1if7SBRCarbonic anhydrase 24.2.1.10.530
1oklMNSCarbonic anhydrase 24.2.1.10.530
4kap1QVCarbonic anhydrase 24.2.1.10.528
1if5FBTCarbonic anhydrase 24.2.1.10.527
3m2nJ74Carbonic anhydrase 24.2.1.10.522
5fltVJJCarbonic anhydrase 24.2.1.10.522
3kigDA4Carbonic anhydrase 24.2.1.10.520
1g45FSBCarbonic anhydrase 24.2.1.10.519
3n2pAYXCarbonic anhydrase 24.2.1.10.519
4mo82VQCarbonic anhydrase 24.2.1.10.519
1bnvAL7Carbonic anhydrase 24.2.1.10.518
2wehFB1Carbonic anhydrase 24.2.1.10.518
1eouSMSCarbonic anhydrase 24.2.1.10.517
3m67E36Carbonic anhydrase 24.2.1.10.517
1jd0AZMCarbonic anhydrase 124.2.1.10.516
3betCTFCarbonic anhydrase 24.2.1.10.515
3m98E02Carbonic anhydrase 24.2.1.10.515
3dd82C7Carbonic anhydrase 24.2.1.10.514
3igpDT7Carbonic anhydrase 24.2.1.10.514
4knjE1FCarbonic anhydrase 24.2.1.10.513
1ydaAZMCarbonic anhydrase 24.2.1.10.512
3s8xE59Carbonic anhydrase 24.2.1.10.512
3dbuD8WCarbonic anhydrase 24.2.1.10.511
3f4xKLTCarbonic anhydrase 24.2.1.10.511
3oikWZBCarbonic anhydrase 24.2.1.10.509
4itp1GDCarbonic anhydrase 24.2.1.10.509
1i9qIOFCarbonic anhydrase 24.2.1.10.508
1bntAL2Carbonic anhydrase 24.2.1.10.507
2x7uWZACarbonic anhydrase 24.2.1.10.507
1kwqSG1Carbonic anhydrase 24.2.1.10.506
5fl49FKCarbonic anhydrase 94.2.1.10.506
1cilETSCarbonic anhydrase 24.2.1.10.502
4m2rBZ1Carbonic anhydrase 24.2.1.10.502
1i9nIOACarbonic anhydrase 24.2.1.10.501
3sbiE90Carbonic anhydrase 24.2.1.10.501
3mhoJ43Carbonic anhydrase 24.2.1.10.500
1bnmAL8Carbonic anhydrase 24.2.1.10.499
3mdzEZLCarbonic anhydrase 74.2.1.10.499
1i9mINWCarbonic anhydrase 24.2.1.10.498
1if8SBSCarbonic anhydrase 24.2.1.10.498
3dccD9ZCarbonic anhydrase 24.2.1.10.497
1i9pIOECarbonic anhydrase 24.2.1.10.496
1oknSTBCarbonic anhydrase 24.2.1.10.496
3m96E38Carbonic anhydrase 24.2.1.10.496
3ml2SU0Carbonic anhydrase 24.2.1.10.496
1g4oBSBCarbonic anhydrase 24.2.1.10.495
1g54FFBCarbonic anhydrase 24.2.1.10.494
3fw3ETSCarbonic anhydrase 44.2.1.10.494
3oimVZ5Carbonic anhydrase 24.2.1.10.494
4bfvZVVPantothenate kinase2.7.1.330.494
4ht2V50Carbonic anhydrase 124.2.1.10.494
1oq5CELCarbonic anhydrase 24.2.1.10.493
3s9tE49Carbonic anhydrase 24.2.1.10.491
3t85SG7Carbonic anhydrase 24.2.1.10.489
2h4nAZMCarbonic anhydrase 24.2.1.10.488
3t84SG6Carbonic anhydrase 24.2.1.10.488
4itoMPXCarbonic anhydrase 24.2.1.10.488
3m40J45Carbonic anhydrase 24.2.1.10.484
3mnaDWHCarbonic anhydrase 24.2.1.10.484
4iwz1GOCarbonic anhydrase 24.2.1.10.484
3wv9FEGHmd co-occurring protein HcgE/0.483
3bl1BL1Carbonic anhydrase 24.2.1.10.482
3mzcS6ICarbonic anhydrase 24.2.1.10.482
2wegFBVCarbonic anhydrase 24.2.1.10.479
3mmfD9HCarbonic anhydrase 24.2.1.10.479
3p5lIT5Carbonic anhydrase 24.2.1.10.479
4k0zMZMCarbonic anhydrase 24.2.1.10.478
3dd0EZLCarbonic anhydrase 24.2.1.10.476
3myqE27Carbonic anhydrase 24.2.1.10.476
4m2vBZ1Carbonic anhydrase 24.2.1.10.476
1cnyEG3Carbonic anhydrase 24.2.1.10.475
3f7uAG4Carbonic anhydrase 44.2.1.10.474
2powI7CCarbonic anhydrase 24.2.1.10.473
4kp8E1GCarbonic anhydrase 124.2.1.10.473
4ilx1EZCarbonic anhydrase 24.2.1.10.472
2wejFB2Carbonic anhydrase 24.2.1.10.471
4bfwZVWPantothenate kinase2.7.1.330.469
4k0tD9ZCarbonic anhydrase 24.2.1.10.468
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.468
4k13ETSCarbonic anhydrase 24.2.1.10.467
3mhcARZCarbonic anhydrase 24.2.1.10.465
4knmE1ECarbonic anhydrase 134.2.1.10.465
1vbiNADMalate/L-lactate dehydrogenase family protein/0.463
2iyfERYOleandomycin glycosyltransferase2.4.10.463
3n4bWWZCarbonic anhydrase 24.2.1.10.463
3oy0OY0Carbonic anhydrase 24.2.1.10.463
1w6hTITPlasmepsin-23.4.23.390.460
3oysOYSCarbonic anhydrase 24.2.1.10.460
4a81DXCMajor pollen allergen Bet v 1-A/0.459
1cnxEG2Carbonic anhydrase 24.2.1.10.458
1x1bSAHC-20 methyltransferase/0.458
3f7bAG5Carbonic anhydrase 44.2.1.10.458
4iae1DXAlr2278 protein/0.458
4lu3AZMCarbonic anhydrase 144.2.1.10.458
4xiwAZMCarbonic anhydrase, alpha type/0.458
4bftZVTPantothenate kinase2.7.1.330.457
4bfxZVXPantothenate kinase2.7.1.330.457
4bfzZVZPantothenate kinase2.7.1.330.457
3l14I7BCarbonic anhydrase 24.2.1.10.456
1okmSABCarbonic anhydrase 24.2.1.10.455
2qimZEAClass 10 plant pathogenesis-related protein/0.455
4bf6X0QCarbonic anhydrase 24.2.1.10.455
4kp5E1FCarbonic anhydrase 124.2.1.10.455
1xe55FEPlasmepsin-23.4.23.390.454
3zncBZ1Carbonic anhydrase 44.2.1.10.454
1xe65FPPlasmepsin-23.4.23.390.453
2c20NADUDP-glucose 4-epimerase/0.451
1pq944BOxysterols receptor LXR-beta/0.450
2uxoTACHTH-type transcriptional regulator TtgR/0.450
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.449
3oyqOYQCarbonic anhydrase 24.2.1.10.449
3mhiJ90Carbonic anhydrase 24.2.1.10.448
2q1qOSPCarbonic anhydrase 24.2.1.10.447
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.447
4gddNAIUDP-galactopyranose mutase/0.447
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.446
3n3jWWVCarbonic anhydrase 24.2.1.10.446
2cy0NAPShikimate dehydrogenase (NADP(+))/0.445
2vn1FK5Peptidylprolyl isomerase/0.445
3dcwEZLCarbonic anhydrase 24.2.1.10.445
3hl0NADMaleylacetate reductase/0.445
3n0nP9BCarbonic anhydrase 24.2.1.10.445
1rdwLARActin, alpha skeletal muscle/0.444
4eb5PLPCysteine desulfurase IscS 2/0.444
4iah1DXAlr2278 protein/0.444
1x1aSAMC-20 methyltransferase/0.443
2gv8NDPThiol-specific monooxygenase1.14.130.443
4a83DXCMajor pollen allergen Bet v 1-A/0.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
1psa0ZLPepsin A3.4.23.10.440
1rj6AZMCarbonic anhydrase 144.2.1.10.440
3fhxPLPPyridoxal kinase2.7.1.350.440