sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1xls | REA | Retinoic acid receptor RXR-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 1.000 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.625 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.616 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.612 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.609 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.601 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.597 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.596 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.595 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.591 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.587 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.586 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.581 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.577 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.573 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.565 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.564 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.563 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.555 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.552 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.550 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.541 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.514 | |
| 3p9t | TCL | Repressor | / | 0.495 | |
| 2xvv | 9DN | Serum albumin | / | 0.492 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.486 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.485 | |
| 2xvw | 9NR | Serum albumin | / | 0.485 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.484 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.483 | |
| 2bxq | IMN | Serum albumin | / | 0.482 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.479 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.477 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.477 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.476 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.476 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.476 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.471 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.471 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.470 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.470 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.469 | |
| 3h1j | SMA | Cytochrome b | / | 0.469 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.469 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.468 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.468 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.468 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.468 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.467 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.467 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.467 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.467 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.467 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.466 | |
| 4hxy | NDP | Plm1 | / | 0.466 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.465 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.465 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.464 | |
| 3b9l | AZZ | Serum albumin | / | 0.464 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.463 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.463 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.463 | |
| 2bxm | IMN | Serum albumin | / | 0.462 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.462 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.462 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.462 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.462 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.461 | |
| 1fml | RTL | Retinol dehydratase | / | 0.461 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.461 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.461 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.461 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.461 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.460 | |
| 2p15 | EZT | Estrogen receptor | / | 0.460 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.460 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.460 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.459 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.459 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.459 | |
| 3cse | N22 | Uncharacterized protein | / | 0.459 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.459 | |
| 4l8u | 9AZ | Serum albumin | / | 0.459 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.459 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.458 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.458 | |
| 1pp9 | SMA | Cytochrome b | / | 0.457 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.457 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.457 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.457 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.457 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.457 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.456 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.456 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.456 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.455 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2wpw | ACO | Orf14 | / | 0.455 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.455 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.455 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.454 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.454 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.454 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3v4e | COA | Putative acetyltransferase SACOL2570 | 2.3.1 | 0.454 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.454 | |
| 4pd6 | URI | Nucleoside permease | / | 0.454 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.454 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.453 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.453 | |
| 2gs7 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.453 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.453 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.453 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.453 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.452 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1u3s | 797 | Estrogen receptor beta | / | 0.452 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.452 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.452 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.452 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.452 | |
| 1ezv | SMA | Cytochrome b | / | 0.451 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.451 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.451 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.451 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3qly | 55V | Uncharacterized protein | / | 0.451 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.451 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.451 | |
| 1e7a | PFL | Serum albumin | / | 0.450 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.450 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.450 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.450 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.450 | |
| 1khr | COA | Streptogramin A acetyltransferase | 2.3.1 | 0.449 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.449 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 2cdu | FAD | NADH oxidase | / | 0.449 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.449 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3l70 | JZV | Cytochrome b | / | 0.449 | |
| 3ntd | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.449 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.449 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.449 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.449 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.449 | |
| 4fv0 | EK3 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.449 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.449 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.449 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1p7t | ACO | Malate synthase G | / | 0.448 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.448 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.448 | |
| 3dol | GWI | Pol protein | / | 0.448 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.448 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3l71 | AZO | Cytochrome b | / | 0.448 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 3qai | XNN | Ketohexokinase | / | 0.448 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.448 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.448 | |
| 4a2j | AS0 | Progesterone receptor | / | 0.448 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.448 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1kb9 | SMA | Cytochrome b | / | 0.447 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.447 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.447 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.447 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.447 | |
| 3tgu | WF3 | Cytochrome b | / | 0.447 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4okt | 198 | Androgen receptor | / | 0.447 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.447 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.446 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.446 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.446 | |
| 2rkf | AB1 | Pol protein | / | 0.446 | |
| 2wpx | ACO | Orf14 | / | 0.446 | |
| 3cxh | SMA | Cytochrome b | / | 0.446 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.445 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.445 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.445 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.445 | |
| 3h18 | PMS | Esterase/lipase | / | 0.445 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.445 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.445 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.445 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.445 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.445 | |
| 4olm | 198 | Androgen receptor | / | 0.445 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.444 | |
| 1iep | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 1rti | HEF | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2ibz | SMA | Cytochrome b | / | 0.444 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.444 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.444 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.444 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.444 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 5c93 | ACP | Two-component system histidine protein kinase | / | 0.444 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ppj | ANY | Cytochrome b | / | 0.443 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.443 | |
| 2bxo | OPB | Serum albumin | / | 0.443 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.443 | |
| 3zux | TCH | Transporter | / | 0.443 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.443 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.443 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.442 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.442 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 2x23 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2ynf | WHU | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.442 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3cx5 | SMA | Cytochrome b | / | 0.442 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.442 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.442 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.441 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1lpf | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.441 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2acw | UPG | Glycosyltransferase | / | 0.441 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.441 | |
| 2qjy | SMA | Cytochrome b | / | 0.441 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3kdt | 7HA | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.441 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.441 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4egn | TWO | Cytochrome P450 | / | 0.441 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.441 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.441 | |
| 4jaq | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.441 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.441 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.441 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.441 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.440 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.440 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.440 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.440 | |
| 3cqu | CQU | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.440 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3d77 | NBB | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.440 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.440 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.440 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4c68 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.440 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.440 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.440 |