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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xdkREARetinoic acid receptor beta

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1xdkREARetinoic acid receptor beta/1.000
4dm6TTBRetinoic acid receptor beta/0.575
4dm8REARetinoic acid receptor beta/0.573
1fd0254Retinoic acid receptor gamma/0.542
1exa394Retinoic acid receptor gamma/0.541
1fcx184Retinoic acid receptor gamma/0.535
1fcy564Retinoic acid receptor gamma/0.523
2lbdREARetinoic acid receptor gamma/0.502
3t8xT8XT-cell surface glycoprotein CD1b/0.469
1diuBDMDihydrofolate reductase1.5.1.30.467
2lf1NDPDihydrofolate reductase1.5.1.30.454
1s7gNADNAD-dependent protein deacylase 2/0.450
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.450
1h36R88Squalene--hopene cyclase4.2.1.1290.447
2hm9TRRDihydrofolate reductase1.5.1.30.447
1disBDMDihydrofolate reductase1.5.1.30.446
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4j6cSTRCytochrome P450 monooxygenase/0.446
2bxoOPBSerum albumin/0.443
3fmz2T1Retinol-binding protein 4/0.442
4dk70KSOxysterols receptor LXR-beta/0.442
5bp9SAHPutative methyltransferase protein/0.442
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.441
2zb8IMNProstaglandin reductase 21.3.1.480.440