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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xb1ALA_VAL_PRO_ILE_ALABaculoviral IAP repeat-containing protein 8

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1xb1ALA_VAL_PRO_ILE_ALABaculoviral IAP repeat-containing protein 8/1.000
1xb0ALA_VAL_PRO_ILEBaculoviral IAP repeat-containing protein 8/0.590
3d7zGK5Mitogen-activated protein kinase 14/0.535
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.504
2vmyFFOSerine hydroxymethyltransferase/0.504
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.500
2he5NDPAldo-keto reductase family 1 member C211.1.10.498
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.496
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.496
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.495
3lkhLT6Genome polyprotein2.7.7.480.494
1a9sNOSPurine nucleoside phosphorylase2.4.2.10.491
1rctNOSPurine nucleoside phosphorylase2.4.2.10.490
4twnB96Ephrin type-A receptor 32.7.10.10.490
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.487
4xrgNADHomospermidine synthase2.5.1.440.487
2e17SAHDiphthine synthase/0.485
2ekaSAHDiphthine synthase/0.485
4fcr0TMHeat shock protein HSP 90-alpha/0.485
1mrqSTRAldo-keto reductase family 1 member C1/0.484
2ij7TPFMycocyclosin synthase1.14.21.90.484
2xf3J01Uncharacterized protein/0.484
3e92G6AMitogen-activated protein kinase 14/0.484
3gcq1BUMitogen-activated protein kinase 14/0.484
1blzACVIsopenicillin N synthase1.21.3.10.482
2balPQAMitogen-activated protein kinase 14/0.481
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.481
1b8nIMGPurine nucleoside phosphorylase2.4.2.10.480
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.480
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.480
3nj0PYVAbscisic acid receptor PYL2/0.480
3vf60H6Glucokinase2.7.1.20.480
4gt8ADPSensor protein VraS2.7.13.30.480
4tmcFMNOld yellow enzyme/0.480
2pg0FADAcyl-CoA dehydrogenase/0.479
1txtCAAHMG-CoA synthase/0.478
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.478
2e07SAHDiphthine synthase/0.478
4iteTEYVitamin D3 receptor/0.478
1dnaCB3Thymidylate synthase/0.477
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.477
3ndjJHZMethyltransferase/0.477
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.476
2c29NAPDihydroflavonol 4-reductase/0.476
2r8pT6FTransketolase 1/0.476
2w6zL21Biotin carboxylase6.3.4.140.476
4tvbNADHomospermidine synthase2.5.1.440.476
2fb35ADGTP 3',8-cyclase4.1.99.180.475
2pb6SAHDiphthine synthase/0.475
2r8oT5XTransketolase 1/0.475
3iphG11Mitogen-activated protein kinase 14/0.475
3zkyWT4Isopenicillin N synthase1.21.3.10.475
2fypRDEEndoplasmin/0.474
2y6fM9FIsopenicillin N synthase1.21.3.10.474
4xbfFADLysine-specific histone demethylase 1A10.474
1gj5130Prothrombin3.4.21.50.473
2emrSAHDiphthine synthase/0.473
3ipkPMSSurface protein adhesin/0.473
3ns2PYVAbscisic acid receptor PYL2/0.473
3f8wADNPurine nucleoside phosphorylase/0.472
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.472
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.471
1trgCB3Thymidylate synthase/0.471
2ejzSAHDiphthine synthase/0.471
2ek2SAHDiphthine synthase/0.471
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.471
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.471
2vcmM11Isopenicillin N synthase1.21.3.10.471
3to3ATPPetrobactin biosynthesis protein AsbB/0.471
3up0D7SaceDAF-12/0.471
1b9iPXG3-amino-5-hydroxybenzoate synthase4.2.1.1440.470
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.470
3itzP66Mitogen-activated protein kinase 14/0.470
3k8q22APurine nucleoside phosphorylase2.4.2.10.470
4xq9NADHomospermidine synthase2.5.1.440.470
1hdrNADDihydropteridine reductase1.5.1.340.469
1jtqLY3Thymidylate synthase/0.469
1obnASVIsopenicillin N synthase1.21.3.10.469
3i2834NBifunctional epoxide hydrolase 23.3.2.100.469
1kceCB3Thymidylate synthase/0.468
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.468
1sbzFMNProbable UbiX-like flavin prenyltransferase/0.468
2e4nSAHDiphthine synthase/0.468
2ociTYCValacyclovir hydrolase3.10.468
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.468
3fhxPLPPyridoxal kinase2.7.1.350.468
1bwkFMNNADPH dehydrogenase 11.6.99.10.467
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.467
2v59LZKBiotin carboxylase6.3.4.140.467
3i1y33NBifunctional epoxide hydrolase 23.3.2.100.467
4xqcNADHomospermidine synthase2.5.1.440.467
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.466
2b1z17MEstrogen receptor/0.466
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.466
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.466
3djfBC3Purine nucleoside phosphorylase/0.466
3up3XCAaceDAF-12/0.466
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.466
1gaeNADGlyceraldehyde-3-phosphate dehydrogenase A/0.465
1nzdUPGDNA beta-glucosyltransferase/0.465
1p5rCOAFormyl-CoA:oxalate CoA-transferase/0.465
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.465
2owgSAHDiphthine synthase/0.465
2vbpVB1Isopenicillin N synthase1.21.3.10.465
2w6pOA4Biotin carboxylase6.3.4.140.465
4v2gCTCTetracycline repressor protein class D/0.465
1axwMTXThymidylate synthase/0.464
1v2hGUNPurine nucleoside phosphorylase2.4.2.10.464
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.464
2emuSAHDiphthine synthase/0.464
2pbzATPUncharacterized protein/0.464
2xujTZ5Acetylcholinesterase3.1.1.70.464
3c36KAIGlutamate receptor ionotropic, kainate 1/0.464
3dz7O8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.464
3hk1B64Fatty acid-binding protein, adipocyte/0.464
4nu0AP5Adenylate kinase/0.464
4ynpSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.464
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.464
1b16NAQAlcohol dehydrogenase1.1.1.10.463
1fmjRTLRetinol dehydratase/0.463
1ulbGUNPurine nucleoside phosphorylase2.4.2.10.463
2dxfGNPNucleoside diphosphate kinase2.7.4.60.463
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.463
2huvSAHDiphthine synthase/0.463
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.463
2zb1GK4Mitogen-activated protein kinase 14/0.463
3g2hKOTGlycogen phosphorylase, muscle form2.4.1.10.463
3vt5YI2Vitamin D3 receptor/0.463
4eh8IRGMitogen-activated protein kinase 14/0.463
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.463
1aj22PHDihydropteroate synthase/0.462
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.462
1dljUGAUDP-glucose 6-dehydrogenase/0.462
1x8lOXRRetinol dehydratase/0.462
1zgv501Prothrombin3.4.21.50.462
2jh6894Prothrombin3.4.21.50.462
3lfcZ86Mitogen-activated protein kinase 14/0.462
4bj9UHBTankyrase-22.4.2.300.462
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.461
2uuk897Prothrombin3.4.21.50.461
2zrjAGSProtein RecA/0.461
3hv3R49Mitogen-activated protein kinase 14/0.461
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.461
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
3u8k09PAcetylcholine-binding protein/0.461
3vi5M4MHematopoietic prostaglandin D synthase/0.461
3vrwYS5Vitamin D3 receptor/0.461
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4hlwTESAndrogen receptor/0.461
4pnmNU1Tankyrase-22.4.2.300.461
1lhuESTSex hormone-binding globulin/0.460
1lvu9PPPurine nucleoside phosphorylase2.4.2.10.460
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.460
2bf7HBIPteridine reductase 11.5.1.330.460
2e7rSAHDiphthine synthase/0.460
2jgsBTNAvidin/0.460
2nm2NEUDihydroneopterin aldolase/0.460
2wo7ASVIsopenicillin N synthase1.21.3.10.460
2z95NDPGDP-mannose 4,6-dehydratase/0.460
3biz61EWee1-like protein kinase2.7.10.20.460
3nr4PYVAbscisic acid receptor PYL2/0.460
3s55NADPutative short-chain dehydrogenase/reductase/0.460
3vev0H4Glucokinase2.7.1.20.460
3zoiM2WIsopenicillin N synthase1.21.3.10.460
4dpeNGHStromelysin-13.4.24.170.460
4l4eCAMCamphor 5-monooxygenase1.14.15.10.460
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.459
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.459
1qjfACSIsopenicillin N synthase1.21.3.10.459
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.459
1svlADPLarge T antigen3.6.40.459
2bu9HFVIsopenicillin N synthase1.21.3.10.459
2eniSAHDiphthine synthase/0.459
2givACOHistone acetyltransferase KAT8/0.459
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.459
2r5nTPPTransketolase 1/0.459
2y5s78HDihydropteroate synthase/0.459
3bx5304Mitogen-activated protein kinase 14/0.459
3c3xNAPEugenol synthase 11.1.1.3180.459
4imfSI3N-acetylneuraminate lyase/0.459
4uyg73BBromodomain-containing protein 2/0.459
5hq8SAHHistone-lysine N-methyltransferase SMYD32.1.1.430.459
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.458
1t4v14AProthrombin3.4.21.50.458
2egbSAHDiphthine synthase/0.458
2p6iSAHDiphthine synthase/0.458
2wipP49Cyclin-dependent kinase 22.7.11.220.458
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.458
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.458
3l77NJPShort-chain alcohol dehydrogenase/0.458
3wv9FEGHmd co-occurring protein HcgE/0.458
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.458
4jq7KJQEpidermal growth factor receptor2.7.10.10.458
4xj43ATCyclic GMP-AMP synthase/0.458
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.458
1ie8KH1Vitamin D3 receptor/0.457
1rkhVD2Vitamin D3 receptor/0.457
1rx1NAPDihydrofolate reductase1.5.1.30.457
1umaIN2Prothrombin3.4.21.50.457
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.457
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.457
2r2mI50Prothrombin3.4.21.50.457
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.457
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.457
3eksCY9Actin-5C/0.457
3elm24FCollagenase 33.4.240.457
3hyg099A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.457
1nceCB3Thymidylate synthase/0.456
1o2g696Prothrombin3.4.21.50.456
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.456
2e8qSAHDiphthine synthase/0.456
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.456
3bv3P39Mitogen-activated protein kinase 14/0.456
3lfeZ84Mitogen-activated protein kinase 14/0.456
4jzr4JREgl nine homolog 1/0.456
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.456
1d3dBZTProthrombin3.4.21.50.455
1dtpAPUDiphtheria toxin/0.455
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.455
2a94AP0L-lactate dehydrogenase1.1.1.270.455
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3c1kT15Prothrombin3.4.21.50.455
3cr0809Wee1-like protein kinase2.7.10.20.455
3dr1C5DVitamin D3 receptor A/0.455
3drcMTXDihydrofolate reductase1.5.1.30.455
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3elePLPAminotransferase/0.455
3kb6NADD-lactate dehydrogenase/0.455
4an4DUDPutative glycosyl transferase/0.455
4b45GSPTubulin-like protein CetZ2/0.455
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.455
4dbzNDPPutative ketoacyl reductase1.3.10.455
4tjy3GNTankyrase-22.4.2.300.455
1bk0ACVIsopenicillin N synthase1.21.3.10.454
1zz1SHHHistone deacetylase-like amidohydrolase3.5.10.454
2bdyUNBProthrombin3.4.21.50.454
2eh4SAHDiphthine synthase/0.454
2yig5ELCollagenase 33.4.240.454
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.454
3fnlSHALactoperoxidase/0.454
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.454
4dh60KNBeta-secretase 13.4.23.460.454
4dvi2IWTankyrase-12.4.2.300.454
4fhh0U3Vitamin D3 receptor A/0.454
4j7gTRHPCZA361.3/0.454
4kxjP34Nucleoprotein/0.454
4oztP1AEcdysone receptor, putative/0.454
4plpNADHomospermidine synthase2.5.1.440.454
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.454
4py06ATP2Y purinoceptor 12/0.454
1d6w00RProthrombin3.4.21.50.453
1m78NDPDihydrofolate reductase1.5.1.30.453
1t86CAMCamphor 5-monooxygenase1.14.15.10.453
2msdGNPMHC class I alpha chain/0.453
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.453
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
2pckSAHDiphthine synthase/0.453
2qbuSAHPrecorrin-2 methyltransferase/0.453
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3gyf51PDihydrofolate reductase1.5.1.30.453
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.453
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.453
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.453
4kgkGTPUncharacterized protein/0.453
4phlPILPhosphodiesterase/0.453
4rvnCOAPhenylacetate-coenzyme A ligase/0.453
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.453
4yfy0FXVioF/0.453
1hfqMOTDihydrofolate reductase1.5.1.30.452
1yslCOAHydroxymethylglutaryl-CoA synthase2.3.3.100.452
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.452
2pitDHTAndrogen receptor/0.452
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.452
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.452
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.452
3mnoDEXGlucocorticoid receptor/0.452
3pvrBYC1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.452
3zqtTESAndrogen receptor/0.452
4bcsBTNAvidin-related protein 4/5/0.452
4bfxZVXPantothenate kinase2.7.1.330.452
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.452
4jauADPSensor histidine kinase/0.452
4jq8KJ8Epidermal growth factor receptor2.7.10.10.452
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.452
4x9mFADUncharacterized protein MG039 homolog/0.452
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.452
1dhrNADDihydropteridine reductase1.5.1.340.451
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
1u4gHPIElastase3.4.24.260.451
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2djxFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.451
2eeqSAHDiphthine synthase/0.451
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.451
2zl9VDAVitamin D3 receptor/0.451
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.451
3h1vTK1Glucokinase2.7.1.20.451
3nmpPYVAbscisic acid receptor PYL2/0.451
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.451
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4l5b1UXDeoxycytidine kinase2.7.1.740.451
4qaiFMNNADPH dehydrogenase/0.451
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.451
3emlZMAAdenosine receptor A2a/0.451
1h74ADPHomoserine kinase2.7.1.390.450
1k21IGNProthrombin3.4.21.50.450
1mfzGDXGDP-mannose 6-dehydrogenase1.1.1.1320.450
1tysTMPThymidylate synthase/0.450
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1ykdCMPAdenylate cyclase/0.450
2dshSAHDiphthine synthase/0.450
2e16SAHDiphthine synthase/0.450
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.450
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.450
2pchSAHDiphthine synthase/0.450
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.450
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.450
2xvv9DNSerum albumin/0.450
3a783EVVitamin D3 receptor/0.450
3ekuCY9Actin-5C/0.450
3gbuATPUncharacterized sugar kinase PH14592.7.10.450
3h4vDVPPteridine reductase 11.5.1.330.450
3qftNAPNADPH--cytochrome P450 reductase/0.450
3r5yF42Uncharacterized protein/0.450
3v76FDAUncharacterized protein/0.450
3w0gW07Vitamin D3 receptor/0.450
4a39GEMUncharacterized protein/0.450
4b65NDPL-ornithine N(5)-monooxygenase/0.450
4c04SFGProtein arginine N-methyltransferase 6/0.450
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.450
4l091URTankyrase-22.4.2.300.450
4l1xNAPAldo-keto reductase family 1 member C2/0.450
5iu86DZAdenosine receptor A2a/0.450
3vw7VPXProteinase-activated receptor 1/0.450
1aiqCB3Thymidylate synthase/0.449
1f5fDHTSex hormone-binding globulin/0.449
1gwrESTEstrogen receptor/0.449
1hb3SCVIsopenicillin N synthase1.21.3.10.449
1kvkATPMevalonate kinase2.7.1.360.449
1mueCDDProthrombin3.4.21.50.449
1x7rGENEstrogen receptor/0.449
1y6rMTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase3.2.2.90.449
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.449
2c4iBTNAvidin/0.449
2clmF6FTryptophan synthase alpha chain/0.449
2ek3SAHDiphthine synthase/0.449
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.449
2jb4A14Isopenicillin N synthase1.21.3.10.449
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.449
2xw19NVSerum albumin/0.449
3fklFKLMitogen-activated protein kinase 14/0.449
3jpuTY4Transcriptional activator protein LasR/0.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.449
4ia3BIVVitamin D3 receptor A/0.449
4tuvCPZCytochrome P450 1191.140.449
4wecNADShort chain dehydrogenase/0.449
5cmx0G6Prothrombin3.4.21.50.449
1ngsTPPTransketolase 12.2.1.10.448
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.448
1pqc444Oxysterols receptor LXR-beta/0.448
1uzwCDHIsopenicillin N synthase1.21.3.10.448
2g1n1IGRenin3.4.23.150.448
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.448
2rhrEMOPutative ketoacyl reductase1.3.10.448
2rtpIMIStreptavidin/0.448
3a8wATPProtein kinase C iota type2.7.11.130.448
3bv2P38Mitogen-activated protein kinase 14/0.448
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.448
3fpzAHZThiamine thiazole synthase/0.448
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.448
3ntrNADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.448
3q9bB3NAcetylpolyamine amidohydrolase/0.448
3sfxJANUncharacterized protein/0.448
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.448
3w5rLOAVitamin D3 receptor/0.448
4baoMVFProthrombin3.4.21.50.448
4df2FMNNADPH dehydrogenase/0.448
4ja1NGHStromelysin-13.4.24.170.448
4pyoSAHCatechol O-methyltransferase2.1.1.60.448
1g28FMNPHY3/0.447
1lv89PPPurine nucleoside phosphorylase2.4.2.10.447
1rxjBNIStreptavidin/0.447
1tkcM6TTransketolase 12.2.1.10.447
1xqp8HGN-glycosylase/DNA lyase/0.447
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.447
2a2xNA9Prothrombin3.4.21.50.447
2amb17HAndrogen receptor/0.447
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.447
2dsiSAHDiphthine synthase/0.447
2e15SAHDiphthine synthase/0.447
2eglSAHDiphthine synthase/0.447
2ftoCB3Thymidylate synthase/0.447
2vq7NAPPutative flavin-containing monooxygenase/0.447
3b05IPEIsopentenyl-diphosphate delta-isomerase/0.447
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.447
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.447
3njoPYVAbscisic acid receptor PYR1/0.447
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.447
4rww2BALmo2692 protein/0.447
1enpNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.446
1iayAVG1-aminocyclopropane-1-carboxylate synthase 24.4.1.140.446
1jwtBLIProthrombin3.4.21.50.446
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.446
1n5dNDPCarbonyl reductase [NADPH] 1/0.446
1nbiSAMGlycine N-methyltransferase2.1.1.200.446
1sreHABStreptavidin/0.446
1tkbN1TTransketolase 12.2.1.10.446
1upw444Oxysterols receptor LXR-beta/0.446
1xm1GAHProthrombin3.4.21.50.446
2dv5SAHDiphthine synthase/0.446
2ejkSAHDiphthine synthase/0.446
2ewnBTXBifunctional ligase/repressor BirA/0.446
2gilGTPRas-related protein Rab-6A/0.446
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
2vbdV10Isopenicillin N synthase1.21.3.10.446
3h3r14HCollagen type IV alpha-3-binding protein/0.446
3mpt1GKMitogen-activated protein kinase 14/0.446
3utu1TSProthrombin3.4.21.50.446
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.446
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.446
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.446
4xzjNADPutative NAD(+)--arginine ADP-ribosyltransferase Vis2.4.2.310.446
4z28BTNHoefavidin/0.446
1c7oPPGHemolysin/0.445
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.445
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.445
2fhnBNIAvidin-related protein 4/5/0.445
2p6lSAHDiphthine synthase/0.445
2pswCOAN-alpha-acetyltransferase 50/0.445
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2wxvWXVCyclin-dependent kinase 22.7.11.220.445
2y882ERPhosphoribosyl isomerase A5.3.1.160.445
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.445
2zsiGA4Gibberellin receptor GID1A30.445
3a26MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.445
3aosJH2Hemolymph juvenile hormone binding protein/0.445
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.445
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.445
3co93MSGenome polyprotein2.7.7.480.445
3dxmN24Actin-related protein 3/0.445
3fln3FNMitogen-activated protein kinase 14/0.445
3hz5Z64Heat shock protein HSP 90-alpha/0.445
3r96ACOMccE protein/0.445
3rlq3RQHeat shock protein HSP 90-alpha/0.445
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.445
3tp0FO5HTH-type transcriptional regulator EthR/0.445
4buwF33Tankyrase-22.4.2.300.445
4du6GTPGTP cyclohydrolase 1/0.445
4fv7E94Mitogen-activated protein kinase 12.7.11.240.445
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.445
4kb81QOCasein kinase I isoform delta2.7.11.10.445
4orkGDPBifunctional AAC/APH2.3.10.445
4q71FADBifunctional protein PutA/0.445
4ubtCOASteroid 3-ketoacyl-CoA thiolase/0.445
5dp2NAPCurF/0.445
5g53NECAdenosine receptor A2a/0.445
1dd6MCIMetallo-beta-lactamase type 2/0.444
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.444
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.444
1kiaSAMGlycine N-methyltransferase2.1.1.200.444
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.444
1pq944BOxysterols receptor LXR-beta/0.444
1ta6177Prothrombin3.4.21.50.444
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.444
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.444
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.444
2dv4SAHDiphthine synthase/0.444
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.444
2ohvNHLGlutamate racemase/0.444
2pcmSAHDiphthine synthase/0.444
2wgeTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.444
2ydoADNAdenosine receptor A2a/0.444
2z2w770Wee1-like protein kinase2.7.10.20.444
3ai3NDPNADPH-sorbose reductase/0.444
3bi6396Wee1-like protein kinase2.7.10.20.444
3lqfNADGalactitol dehydrogenase/0.444
3lxiCAMCytochrome P450/0.444
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
3tlh3TLGag-Pol polyprotein3.4.23.160.444
4a7b3W4Collagenase 33.4.240.444
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.444
4bekXK0Beta-secretase 13.4.23.460.444
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.444
4ia1BIVVitamin D3 receptor A/0.444
4jq3ZOMAldo-keto reductase family 1 member C2/0.444
4m11MXMProstaglandin G/H synthase 21.14.99.10.444
4okkU5P3'-5' exoribonuclease MT2234.1/0.444
4qbiAP5Adenylate kinase/0.444
4qmySTUSerine/threonine-protein kinase 242.7.11.10.444
4rujVDXVitamin D3 receptor A/0.444
4z0hNADGlyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic1.2.1.120.444
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.444
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.444
4xnw2IDP2Y purinoceptor 1/0.444
1ddtAPUDiphtheria toxin/0.443
1drhNAPDihydrofolate reductase1.5.1.30.443
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1jolFFODihydrofolate reductase1.5.1.30.443
1nm6L86Prothrombin3.4.21.50.443
1p4aPCPPur operon repressor/0.443
1pd9CO4Dihydrofolate reductase1.5.1.30.443
1sbyNADAlcohol dehydrogenase1.1.1.10.443
1t79DHTAndrogen receptor/0.443
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.443
2hr8SAHDiphthine synthase/0.443
2iviACWIsopenicillin N synthase1.21.3.10.443
2owfSAHDiphthine synthase/0.443
2p2xSAHDiphthine synthase/0.443
2p83MR0Beta-secretase 13.4.23.460.443
2pksG44Prothrombin3.4.21.50.443
2rlcCHDCholoylglycine hydrolase3.5.1.240.443
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.443
2y60M8FIsopenicillin N synthase1.21.3.10.443
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.443
2zlcVDXVitamin D3 receptor/0.443
3akn11DFatty acid-binding protein, intestinal/0.443
3dmhSAMProbable ribosomal RNA small subunit methyltransferase/0.443
3h3qH13Collagen type IV alpha-3-binding protein/0.443
3pvcFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.443
3vruYS3Vitamin D3 receptor/0.443
4fqsLYAThymidylate synthase ThyA/0.443
4g1y0VOVitamin D3 receptor A/0.443
4jtrIBPAldo-keto reductase family 1 member C2/0.443
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.443
4udcDEXGlucocorticoid receptor/0.443
5fkkTDCTetracycline repressor protein class D/0.443
1k6mAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 12.7.1.1050.442
1mu6CDAProthrombin3.4.21.50.442
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.442
1xp8AGSProtein RecA/0.442
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.442
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.442
2nniMTKCytochrome P450 2C8/0.442
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.442
2ym2NAPPhenylacetone monooxygenase1.14.13.920.442
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.442
3ed1GA3Gibberellin receptor GID1/0.442
3fr4F8AFatty acid-binding protein, adipocyte/0.442
3fwjCAMCamphor 5-monooxygenase1.14.15.10.442
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.442
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3ivcFG4Pantothenate synthetase6.3.2.10.442
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.442
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.442
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.442
3rfxNADUronate dehydrogenase/0.442
4e32DWNMethyltransferase/0.442
4enhFVXCholesterol 24-hydroxylase/0.442
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.442
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4ise1FWGlucokinase2.7.1.20.442
4olfHFGProline--tRNA ligase6.1.1.150.442
4tlaADPCircadian clock protein kinase KaiC2.7.11.10.442
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.442
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.442
5jtbZMAAdenosine receptor A2a/0.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.441
1g6kNADGlucose 1-dehydrogenase1.1.1.470.441
1h50FMNPentaerythritol tetranitrate reductase/0.441
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1u5cBIKL-lactate dehydrogenase1.1.1.270.441
1wur8DGGTP cyclohydrolase 1/0.441
1xxjUNCUricase1.7.3.30.441
1yryMSGPurine nucleoside phosphorylase2.4.2.10.441
1zosMTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/0.441
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2g44T3OEstrogen receptor/0.441
2jfhLK1UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
2rg5279Mitogen-activated protein kinase 14/0.441
2rtiGLLStreptavidin/0.441
2xviFADPutative flavin-containing monooxygenase/0.441
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.441
2z0ySAMRibosomal RNA small subunit methyltransferase E/0.441
2zrvFNRIsopentenyl-diphosphate delta-isomerase/0.441
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.441
3clsFADElectron transfer flavoprotein subunit alpha/0.441
3cppCAMCamphor 5-monooxygenase1.14.15.10.441
3d3wNAPL-xylulose reductase1.1.1.100.441
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.441
3qto10PProthrombin3.4.21.50.441
3tq8TOPDihydrofolate reductase/0.441
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3wrlCAMCamphor 5-monooxygenase1.14.15.10.441
4c3sNADAldehyde Dehydrogenase/0.441
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4g1z0VPVitamin D3 receptor A/0.441
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.441
4jr3KJREpidermal growth factor receptor2.7.10.10.441
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4u0mATPCyclic GMP-AMP synthase/0.441
1bwlFMNNADPH dehydrogenase 11.6.99.10.440
1bygSTUTyrosine-protein kinase CSK/0.440
1dfoFFOSerine hydroxymethyltransferase2.1.2.10.440
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.440
1jzqILAIsoleucine--tRNA ligase6.1.1.50.440
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.440
1qoqIGPTryptophan synthase alpha chain/0.440
1qsnCOAHAT A1/0.440
1rx8FOLDihydrofolate reductase1.5.1.30.440
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2b4rNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
2dxvSAHDiphthine synthase/0.440
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.440
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.440
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.440
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
2hj3FADFAD-linked sulfhydryl oxidase ERV1/0.440
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.440
2in6839Wee1-like protein kinase2.7.10.20.440
2jibADPOxalyl-CoA decarboxylase4.1.1.80.440
2qn3F55Glycogen phosphorylase, muscle form2.4.1.10.440
2qo9ANPEphrin type-A receptor 32.7.10.10.440
2qw8NAPEugenol synthase 11.1.1.3180.440
2rtfBTNStreptavidin/0.440
2tpsTPSThiamine-phosphate synthase/0.440
2ylxFADPhenylacetone monooxygenase1.14.13.920.440
3br9DEYGenome polyprotein2.7.7.480.440
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.440
3fktSIIBeta-secretase 13.4.23.460.440
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.440
3sf6FDAGlutaryl-CoA dehydrogenase/0.440
3w8eNAD3-hydroxybutyrate dehydrogenase/0.440
4ajj88RL-lactate dehydrogenase A chain1.1.1.270.440
4b3aTACTetracycline repressor protein class D/0.440
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4i0h1BLBeta-secretase 13.4.23.460.440
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.440
4kwhNAPReductase homolog/0.440
4uofDATNucleoside diphosphate kinase/0.440
4yusFMNFamily 3 adenylate cyclase/0.440
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440
3qakUKAAdenosine receptor A2a/0.440