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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1x96NAPAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1x96NAPAldose reductase1.1.1.211.000
1x98NAPAldose reductase1.1.1.210.814
2iq0NAPAldose reductase1.1.1.210.763
2acsNAPAldose reductase1.1.1.210.712
2j8tNAPAldose reductase1.1.1.210.709
1az2NAPAldose reductase1.1.1.210.701
2acqNAPAldose reductase1.1.1.210.677
1z8aNAPAldose reductase1.1.1.210.639
3q65NAPAldose reductase1.1.1.210.604
3q67NAPAldose reductase1.1.1.210.593
3v36NAPAldose reductase1.1.1.210.593
1ah4NAPAldose reductase1.1.1.210.584
2acuNAPAldose reductase1.1.1.210.567
2pfhNDPAldose reductase1.1.1.210.551
1adsNAPAldose reductase1.1.1.210.540
2pf8NDPAldose reductase1.1.1.210.529
2pevNDPAldose reductase1.1.1.210.513
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.499
3o3rNAPAldose reductase-related protein 11.1.1.210.485
3qkzNAPAldose reductase-related protein 11.1.1.210.476
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.468
3h7rNAPAldo-keto reductase family 4 member C8/0.456
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
4g5dNDPProstaglandin F synthase1.1.1.1880.454
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.452
1c9wNAPAldose reductase-related protein 2/0.451