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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1wuaAP8Actin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1wuaAP8Actin, alpha skeletal muscle/1.000
2fxuBIDActin, alpha skeletal muscle/0.498
3ekuCY9Actin-5C/0.491
3eksCY9Actin-5C/0.470
2gevCOKPantothenate kinase2.7.1.330.461
2gesCOKPantothenate kinase2.7.1.330.458
2zsaADPPantothenate kinase2.7.1.330.454
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.448
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.447
2geuCOKPantothenate kinase2.7.1.330.442