sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1wqv | PSM | Coagulation factor VII | 3.4.21.21 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1wqv | PSM | Coagulation factor VII | 3.4.21.21 | 1.000 | |
| 1wtg | 3BP | Coagulation factor VII | 3.4.21.21 | 0.667 | |
| 2zp0 | PI0 | Coagulation factor VII | 3.4.21.21 | 0.588 | |
| 2c4f | GIL | Coagulation factor VII | 3.4.21.21 | 0.582 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.562 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.561 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.551 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.547 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.543 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.542 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.542 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.539 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.539 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.537 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.535 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.535 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.532 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.531 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.531 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.531 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.530 | |
| 1wv7 | 5PI | Coagulation factor VII | 3.4.21.21 | 0.528 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.526 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.526 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.524 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.523 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.523 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.519 | |
| 1f92 | UKP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.518 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.518 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.518 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.517 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.517 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.517 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.517 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.517 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.516 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.516 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.516 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.515 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.514 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.514 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.514 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.513 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.509 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.508 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.507 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.506 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.506 | |
| 1c5n | ESI | Prothrombin | 3.4.21.5 | 0.505 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.504 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.504 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.504 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.503 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.503 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.502 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.501 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.501 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.501 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.500 | |
| 3qto | 10P | Prothrombin | 3.4.21.5 | 0.500 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.499 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.498 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.498 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.497 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.496 | |
| 4fud | 6UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.495 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.494 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.494 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1vja | 7IN | Urokinase-type plasminogen activator | 3.4.21.73 | 0.493 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.493 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.492 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.491 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.491 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.491 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.490 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.489 | |
| 1w13 | SM1 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.489 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.488 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.487 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.486 | |
| 2bxt | C2D | Prothrombin | 3.4.21.5 | 0.486 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.485 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.485 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.485 | |
| 3f68 | 91U | Prothrombin | 3.4.21.5 | 0.485 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.484 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.484 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.483 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.483 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.483 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.483 | |
| 3v49 | PK0 | Androgen receptor | / | 0.483 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.483 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.482 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.482 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.481 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.481 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.481 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.481 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.480 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.480 | |
| 4loc | BTN | Pyruvate carboxylase | / | 0.480 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.479 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.479 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.479 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.479 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.479 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.479 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.478 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.478 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.478 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.478 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.477 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.477 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.477 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.477 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.477 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.476 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.476 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.476 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.476 | |
| 4fui | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.476 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.475 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.474 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.474 | |
| 1b8n | IMG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.473 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.473 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.472 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.472 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.472 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.472 | |
| 2y5h | Y5H | Coagulation factor X | 3.4.21.6 | 0.472 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.472 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.472 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.472 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.472 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.472 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.471 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.471 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.471 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.471 | |
| 3cnp | SP7 | Polyamine oxidase FMS1 | / | 0.471 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.471 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.470 | |
| 3awh | FMN | FMN-binding protein | / | 0.470 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.470 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.470 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4fuf | 8UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.470 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.470 | |
| 1cgz | STL | Chalcone synthase 2 | 2.3.1.74 | 0.469 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.469 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.469 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.469 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.469 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.469 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.469 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.468 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.468 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.468 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.468 | |
| 2ewv | ADP | Twitching motility protein PilT | / | 0.468 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 3eku | CY9 | Actin-5C | / | 0.468 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.468 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.468 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.468 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.468 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.468 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.467 | |
| 1owi | 426 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.467 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.467 | |
| 4e2d | FMN | Dehydrogenase | / | 0.467 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.467 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.467 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.466 | |
| 1owd | 497 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.466 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.466 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.466 | |
| 4fub | 4UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.466 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.466 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.465 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.465 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.465 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.465 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.465 | |
| 4el0 | D1K | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.465 | |
| 4ig6 | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.465 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.464 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.464 | |
| 1aj2 | 2PH | Dihydropteroate synthase | / | 0.463 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.463 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.463 | |
| 3aeb | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.463 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.463 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.463 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.463 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.463 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.463 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.463 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.463 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.462 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.462 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.462 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.462 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.462 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.462 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.462 | |
| 2ohv | NHL | Glutamate racemase | / | 0.462 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.462 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.462 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.462 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.461 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.461 | |
| 2g2z | COZ | Malonyl CoA-acyl carrier protein transacylase | 2.3.1.39 | 0.461 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.461 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 4e31 | JHZ | Methyltransferase | / | 0.461 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.461 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.460 | |
| 1nfy | RTR | Coagulation factor X | 3.4.21.6 | 0.460 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.460 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.460 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.460 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.460 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.460 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.460 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.459 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.459 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.459 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.459 | |
| 1vdc | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.459 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.459 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.459 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.459 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.459 | |
| 2xby | 63C | Coagulation factor X | 3.4.21.6 | 0.459 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.459 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.459 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.459 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.459 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3tdj | 3TJ | Glutamate receptor 2 | / | 0.459 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.459 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.459 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.459 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.458 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.458 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 1z45 | UPG | Bifunctional protein GAL10 | 5.1.3.2 | 0.458 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.458 | |
| 2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.458 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.458 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.458 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.458 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.458 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4nvk | 2NY | Peroxidase | / | 0.458 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.457 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 1rct | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.457 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.457 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.457 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.457 | |
| 3n4l | 842 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.457 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.457 | |
| 4e2b | FMN | Dehydrogenase | / | 0.457 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.457 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.456 | |
| 2buf | ADP | Acetylglutamate kinase | / | 0.456 | |
| 2e8q | SAH | Diphthine synthase | / | 0.456 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.456 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.456 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.456 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.455 | |
| 1lqd | CMI | Coagulation factor X | 3.4.21.6 | 0.455 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.455 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.455 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.455 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.455 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3nk7 | SAM | 23S rRNA (adenosine(1067)-2'-O)-methyltransferase | / | 0.455 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 3utu | 1TS | Prothrombin | 3.4.21.5 | 0.455 | |
| 4ban | M6S | Prothrombin | 3.4.21.5 | 0.455 | |
| 4e9a | QAP | Peptide deformylase | / | 0.455 | |
| 4jk3 | NAD | Uncharacterized protein | / | 0.455 | |
| 4l4x | NDP | AmphI | / | 0.455 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.455 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.455 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.454 | |
| 1in5 | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.454 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.454 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.454 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.454 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.454 | |
| 2op9 | WR1 | Orf1ab polyprotein | / | 0.454 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.454 | |
| 3a6q | FMN | FMN-binding protein | / | 0.454 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.454 | |
| 3bm1 | FMN | Putative NAD(P)H nitroreductase YdjA | / | 0.454 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3e39 | FMN | Nitroreductase | / | 0.454 | |
| 3ilt | TRU | Glutamate receptor 2 | / | 0.454 | |
| 3lcv | SAM | 16S rRNA (guanine(1405)-N(7))-methyltransferase | 2.1.1.179 | 0.454 | |
| 3v0x | ANH | Cationic trypsin | 3.4.21.4 | 0.454 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.454 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4e8y | IHA | D-beta-D-heptose 7-phosphate kinase | / | 0.454 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.454 | |
| 4kwh | NAP | Reductase homolog | / | 0.454 | |
| 4mfe | BTN | Pyruvate carboxylase | / | 0.454 | |
| 4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.454 | |
| 1bif | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.453 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.453 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 1jsc | TPP | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.453 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 1uh5 | TCL | Enoyl-ACP reductase | / | 0.453 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 2b8v | 3BN | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 2vwh | NAP | Glucose 1-dehydrogenase | / | 0.453 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.453 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.453 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.453 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.453 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.453 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.453 | |
| 4jic | FMN | GTN Reductase | / | 0.453 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.453 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.453 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.453 | |
| 1ib6 | NAD | Malate dehydrogenase | / | 0.452 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.452 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.452 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.452 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.452 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.452 | |
| 2py7 | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.452 | |
| 2r3a | SAM | Histone-lysine N-methyltransferase SUV39H2 | 2.1.1.43 | 0.452 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.452 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.452 | |
| 5a8a | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.452 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.451 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.451 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.451 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1emd | NAD | Malate dehydrogenase | / | 0.451 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.451 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.451 | |
| 1rz0 | FAD | Phenol 2-hydroxylase component B | / | 0.451 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.451 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.451 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.451 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.451 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.451 | |
| 3ioe | A7D | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.451 | |
| 3vy2 | FMN | FMN-binding protein | / | 0.451 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.451 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.451 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.451 | |
| 4xbo | SAH | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ | 2.1.1.200 | 0.451 | |
| 5a3b | APR | SIR2 family protein | / | 0.451 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.451 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.450 | |
| 1zpt | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.450 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.450 | |
| 2qen | ADP | Walker-Type ATPase | / | 0.450 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.450 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.450 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3pvc | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.450 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 4bmp | FMN | Protein NrdI | / | 0.450 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 4eep | FMN | Phototropin-2 | 2.7.11.1 | 0.450 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.450 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.450 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.450 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.450 | |
| 5jjs | SAH | Genome polyprotein | / | 0.450 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.449 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.449 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.449 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.449 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.449 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.449 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.449 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.449 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.449 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.449 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.448 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.448 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.448 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.448 | |
| 1o6z | NAD | Malate dehydrogenase | / | 0.448 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 1wng | SAH | Diphthine synthase | / | 0.448 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.448 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.448 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.448 | |
| 2y3p | SM8 | DNA gyrase subunit A | / | 0.448 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.448 | |
| 3e51 | N35 | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.448 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.448 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.448 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.448 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.448 | |
| 3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.448 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.448 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.448 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.448 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.448 | |
| 1b8u | NAD | Malate dehydrogenase | / | 0.447 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.447 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.447 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.447 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1svm | ATP | Large T antigen | 3.6.4 | 0.447 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.447 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.447 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.447 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.447 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2dxw | SAH | Diphthine synthase | / | 0.447 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2pcm | SAH | Diphthine synthase | / | 0.447 | |
| 3bhr | THG | Thymidylate synthase | / | 0.447 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.447 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.447 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.447 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.447 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 4hh4 | SAH | CcbJ | / | 0.447 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.447 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.447 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.446 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.446 | |
| 2p5c | SAH | Diphthine synthase | / | 0.446 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.446 | |
| 2x7b | COA | N-alpha-acetyltransferase | 2.3.1 | 0.446 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.446 | |
| 3eya | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.446 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.446 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.446 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.446 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 4cmf | PXG | Uncharacterized protein | / | 0.446 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.446 | |
| 4lb2 | DM5 | Serum albumin | / | 0.446 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.446 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.446 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.446 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.445 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.445 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.445 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.445 | |
| 2c3c | NAP | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.445 | |
| 2nr4 | FMN | Conserved protein | / | 0.445 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.445 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.445 | |
| 3ck7 | ACX | Starch-binding protein SusD | / | 0.445 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.445 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.445 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.445 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.445 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.445 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.445 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.445 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.445 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.445 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.445 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.445 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4z0g | 5GP | Inosine-5'-monophosphate dehydrogenase | / | 0.445 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.444 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.444 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.444 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.444 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.444 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.444 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.444 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.444 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 3pft | FMN | Flavin reductase | / | 0.444 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.444 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.444 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.443 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 1iqg | XME | Coagulation factor X | 3.4.21.6 | 0.443 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 1u5c | BIK | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 1z3c | SA8 | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.443 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.443 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.443 | |
| 2ag0 | TPP | Benzaldehyde lyase | / | 0.443 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.443 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.443 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.443 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.443 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.443 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.443 | |
| 3iaa | TYD | CalG2 | / | 0.443 | |
| 3lnc | 5GP | Guanylate kinase | / | 0.443 | |
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.443 | |
| 3mje | NDP | AmphB | / | 0.443 | |
| 3w2j | QRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.443 | |
| 3w77 | FMN | FMN-dependent NADH-azoreductase | / | 0.443 | |
| 4btt | VYR | Coagulation factor X | 3.4.21.6 | 0.443 | |
| 4eu4 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.443 | |
| 5efw | FMN | NPH1-1 | / | 0.443 | |
| 5fsy | AR6 | Uncharacterized protein | / | 0.443 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.442 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.442 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.442 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.442 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.442 | |
| 2e1m | FAD | L-glutamate oxidase | / | 0.442 | |
| 2eeq | SAH | Diphthine synthase | / | 0.442 | |
| 2ge3 | ACO | Probable acetyltransferase | / | 0.442 | |
| 2r8p | T6F | Transketolase 1 | / | 0.442 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.442 | |
| 2y5g | FJD | Coagulation factor X | 3.4.21.6 | 0.442 | |
| 3fg2 | FAD | Putative rubredoxin reductase | / | 0.442 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.442 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3p3c | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.442 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.442 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4fnc | HMU | G/T mismatch-specific thymine DNA glycosylase | 3.2.2.29 | 0.442 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 4j17 | 1HQ | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.442 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.442 | |
| 5f59 | SAH | Histone-lysine N-methyltransferase 2C | 2.1.1.43 | 0.442 | |
| 5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.442 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.441 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.441 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.441 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.441 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.441 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.441 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.441 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.441 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.441 | |
| 3wwm | ADP | [LysW]-aminoadipate kinase | / | 0.441 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.441 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.441 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.441 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.441 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.441 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.441 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.441 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.441 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.441 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.441 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1fdo | MGD | Formate dehydrogenase H | 1.1.99.33 | 0.440 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.440 | |
| 1jkx | 138 | Phosphoribosylglycinamide formyltransferase | / | 0.440 | |
| 1m8g | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.440 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.440 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2cji | GSK | Coagulation factor X | 3.4.21.6 | 0.440 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.440 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.440 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.440 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2z6r | SAH | Diphthine synthase | / | 0.440 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.440 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.440 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 3eks | CY9 | Actin-5C | / | 0.440 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.440 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3qvs | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.440 | |
| 3tlc | 7MD | Microcin C7 self-immunity protein MccF | / | 0.440 | |
| 3w1x | XRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.440 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.440 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4b4g | KKT | Glucose-1-phosphate thymidylyltransferase | / | 0.440 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.440 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.440 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.440 |