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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w35FADFerredoxin--NADP reductase1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1w35FADFerredoxin--NADP reductase1.18.1.21.000
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.638
1gjrFADFerredoxin--NADP reductase1.18.1.20.630
3vo2FADFerredoxin--NADP reductase/0.623
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.619
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.616
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.615
3zbtFADFerredoxin--NADP reductase1.18.1.20.615
1gr1FADFerredoxin--NADP reductase1.18.1.20.608
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.604
1gawFADFerredoxin/0.602
3zc3FADFerredoxin--NADP reductase1.18.1.20.602
1h42FADFerredoxin--NADP reductase1.18.1.20.599
1sm4FADFerredoxin--NADP reductase/0.598
1w87FADFerredoxin--NADP reductase1.18.1.20.591
1e62FADFerredoxin--NADP reductase1.18.1.20.590
4c43FADFerredoxin--NADP reductase1.18.1.20.585
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.579
1gaqFADFerredoxin/0.579
2b5oFADFerredoxin--NADP reductase1.18.1.20.578
3w5uFADFerredoxin/0.578
2rc6FADFerredoxin--NADP reductase/0.574
1e64FADFerredoxin--NADP reductase1.18.1.20.569
1e63FADFerredoxin--NADP reductase1.18.1.20.568
1queFADFerredoxin--NADP reductase1.18.1.20.568
3fpkFADFerredoxin-NADP reductase/0.567
1qgyFADFerredoxin--NADP reductase1.18.1.20.565
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.564
2ok8FADFerredoxin--NADP reductase, apicoplast/0.564
3qfsFADNADPH--cytochrome P450 reductase/0.564
4bprFADFerredoxin--NADP reductase1.18.1.20.562
4yaoFADNADPH--cytochrome P450 reductase/0.559
1bjkFADFerredoxin--NADP reductase1.18.1.20.552
1go2FADFerredoxin--NADP reductase1.18.1.20.546
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.544
1h85FADFerredoxin--NADP reductase1.18.1.20.544
3qfcFADNADPH--cytochrome P450 reductase/0.542
3jqrFADFerredoxin--NADP reductase, apicoplast/0.537
1qgzFADFerredoxin--NADP reductase1.18.1.20.530
1qh0FADFerredoxin--NADP reductase1.18.1.20.526
3qftFADNADPH--cytochrome P450 reductase/0.525
1amoFADNADPH--cytochrome P450 reductase/0.520
1ogjFADFerredoxin--NADP reductase1.18.1.20.500
2rc5FADFerredoxin--NADP reductase/0.496
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.492
1b2rFADFerredoxin--NADP reductase1.18.1.20.485
1ogiFADFerredoxin--NADP reductase1.18.1.20.482
2ok7FADFerredoxin--NADP reductase, apicoplast/0.482
1fdrFADFerredoxin--NADP reductase1.18.1.20.481
4fk8FADFerredoxin--NADP reductase/0.480
1a8pFADFerredoxin--NADP reductase/0.479
1j9zFADNADPH--cytochrome P450 reductase/0.479
1ja0FADNADPH--cytochrome P450 reductase/0.479
3opxU5PSuppressor of disruption of TFIIS/0.478
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.478
1f20FADNitric oxide synthase, brain1.14.13.390.474
5dp2NAPCurF/0.474
2vnkFADNADPH:ferredoxin reductase/0.472
1tllFADNitric oxide synthase, brain1.14.13.390.470
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.470
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.468
3ojxFADNADPH--cytochrome P450 reductase/0.468
2cndFADNitrate reductase [NADH]1.7.1.10.467
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.464
4fl0PLPAminotransferase ALD1, chloroplastic2.6.10.464
2vyqFADFerredoxin--NADP reductase1.18.1.20.462
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.461
2w6zL21Biotin carboxylase6.3.4.140.461
3rsv3RSBeta-secretase 13.4.23.460.460
4k1xFADNADPH:ferredoxin reductase/0.460
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.458
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.457
1qoqIGPTryptophan synthase alpha chain/0.457
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.457
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.455
2hk9NAPShikimate dehydrogenase (NADP(+))/0.455
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.455
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.453
2gjnFMNNitronate monooxygenase1.13.12.160.453
5ah5LSSLeucine--tRNA ligase/0.453
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.452
2gv8NDPThiol-specific monooxygenase1.14.130.452
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.452
2pidYSATyrosine--tRNA ligase, mitochondrial6.1.1.10.451
2uxoTACHTH-type transcriptional regulator TtgR/0.451
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.451
1bsvNDPGDP-L-fucose synthase/0.450
1x1bSAHC-20 methyltransferase/0.450
2zevB71Geranylgeranyl pyrophosphate synthase/0.450
4bftZVTPantothenate kinase2.7.1.330.450
4jtqNAPAldo-keto reductase family 1 member C2/0.450
1knpFADL-aspartate oxidase1.4.3.160.449
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.449
3wqmB29Diterpene synthase3.1.7.80.449
4aoaIK2Beta-phenylalanine transaminase2.6.10.449
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.449
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.448
2aouCQAHistamine N-methyltransferase2.1.1.80.448
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.448
2rqfJH3Hemolymph juvenile hormone binding protein/0.448
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.447
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.447
2vnjFADNADPH:ferredoxin reductase/0.447
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.447
3p0fBAUUridine phosphorylase 22.4.2.30.447
4gg1TZDBenzoylformate decarboxylase4.1.1.70.447
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.447
4n3l2FNProthrombin3.4.21.50.447
1z71L17Prothrombin3.4.21.50.446
2e0nSAHPrecorrin-2 C20-methyltransferase/0.446
3ojxFMNNADPH--cytochrome P450 reductase/0.446
1xs7MMIBeta-secretase 13.4.23.460.445
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.445
4c72TLG3-oxoacyl-ACP synthase/0.445
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.445
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.445
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.444
4wx2F6FTryptophan synthase alpha chain/0.444
4wx2F6FTryptophan synthase beta chain4.2.1.200.444
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.443
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.443
3rtnRTNBeta-secretase 13.4.23.460.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.443
2e7rSAHDiphthine synthase/0.442
2g247IGRenin3.4.23.150.442
2ji9ADPOxalyl-CoA decarboxylase4.1.1.80.442
2wu4HBPAcetylcholinesterase3.1.1.70.442
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.442
4r81FMNPredicted NADH dehydrogenase/0.442
4v2gITCTetracycline repressor protein class D/0.442
1xddAAYIntegrin alpha-L/0.441
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2bgiFADNADPH:ferredoxin reductase/0.441
2c12FADNitroalkane oxidase1.7.3.10.441
2ejzSAHDiphthine synthase/0.441
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.441
3csoXNIGenome polyprotein2.7.7.480.441
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3tkyN7I(Iso)eugenol O-methyltransferase2.1.1.1460.441
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.441
4c73TLH3-oxoacyl-ACP synthase/0.441
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.440
2vcmM11Isopenicillin N synthase1.21.3.10.440
4b7754MBeta-secretase 13.4.23.460.440
4q0kGA3Phytohormone-binding protein/0.440