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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w0xOLOCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1w0xOLOCyclin-dependent kinase 22.7.11.221.000
3s2pPMUCyclin-dependent kinase 22.7.11.220.609
2a0cCK9Cyclin-dependent kinase 22.7.11.220.597
4fki09KCyclin-dependent kinase 22.7.11.220.597
4fkr45KCyclin-dependent kinase 22.7.11.220.596
1oitHDTCyclin-dependent kinase 22.7.11.220.582
4ek610KCyclin-dependent kinase 22.7.11.220.576
1pxoCK7Cyclin-dependent kinase 22.7.11.220.572
3r1yX76Cyclin-dependent kinase 22.7.11.220.569
1pxmCK5Cyclin-dependent kinase 22.7.11.220.567
2c6o4SPCyclin-dependent kinase 22.7.11.220.566
2btrU73Cyclin-dependent kinase 22.7.11.220.561
3rkb12ZCyclin-dependent kinase 22.7.11.220.557
3r7yZ04Cyclin-dependent kinase 22.7.11.220.553
4bgh3I6Cyclin-dependent kinase 22.7.11.220.553
4fkt48KCyclin-dependent kinase 22.7.11.220.553
2btsU32Cyclin-dependent kinase 22.7.11.220.552
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.549
3lfsA07Cyclin-dependent kinase 22.7.11.220.549
1gii1PUCyclin-dependent kinase 22.7.11.220.548
3rni21ZCyclin-dependent kinase 22.7.11.220.547
1ke5LS1Cyclin-dependent kinase 22.7.11.220.546
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.545
3iggEFQCyclin-dependent kinase 22.7.11.220.545
3s1h56ZCyclin-dependent kinase 22.7.11.220.545
3rmf20ZCyclin-dependent kinase 22.7.11.220.544
3rak03ZCyclin-dependent kinase 22.7.11.220.543
2r3p3SCCyclin-dependent kinase 22.7.11.220.542
3qzgX67Cyclin-dependent kinase 22.7.11.220.542
1gih1PUCyclin-dependent kinase 22.7.11.220.541
3ezvEZVCyclin-dependent kinase 22.7.11.220.541
1w8cN69Cyclin-dependent kinase 22.7.11.220.539
3qtrX36Cyclin-dependent kinase 22.7.11.220.539
1g5sI17Cyclin-dependent kinase 22.7.11.220.537
3rk909ZCyclin-dependent kinase 22.7.11.220.537
3r8lZ30Cyclin-dependent kinase 22.7.11.220.536
3r7uX96Cyclin-dependent kinase 22.7.11.220.535
4fkg4CKCyclin-dependent kinase 22.7.11.220.534
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.533
3r9dX6BCyclin-dependent kinase 22.7.11.220.533
4fkq42KCyclin-dependent kinase 22.7.11.220.533
2r3lSCWCyclin-dependent kinase 22.7.11.220.532
3qqhX0ACyclin-dependent kinase 22.7.11.220.531
3qxpX64Cyclin-dependent kinase 22.7.11.220.531
3sw418KCyclin-dependent kinase 22.7.11.220.531
4ek816KCyclin-dependent kinase 22.7.11.220.531
1v1k3FPCyclin-dependent kinase 22.7.11.220.530
2w06FRVCyclin-dependent kinase 22.7.11.220.530
4fklCK2Cyclin-dependent kinase 22.7.11.220.529
2j9mPY8Cyclin-dependent kinase 22.7.11.220.528
2r3kSCQCyclin-dependent kinase 22.7.11.220.528
2vv9IM9Cyclin-dependent kinase 22.7.11.220.528
3qwjX6ACyclin-dependent kinase 22.7.11.220.528
3fz1B98Cyclin-dependent kinase 22.7.11.220.527
3r83Z14Cyclin-dependent kinase 22.7.11.220.527
1b38ATPCyclin-dependent kinase 22.7.11.220.526
1ke6LS2Cyclin-dependent kinase 22.7.11.220.526
1urwI1PCyclin-dependent kinase 22.7.11.220.526
4fkpLS5Cyclin-dependent kinase 22.7.11.220.526
1p2a5BNCyclin-dependent kinase 22.7.11.220.525
1ykr628Cyclin-dependent kinase 22.7.11.220.525
3lfnA27Cyclin-dependent kinase 22.7.11.220.525
2r3jSCJCyclin-dependent kinase 22.7.11.220.524
4lyn1YGCyclin-dependent kinase 22.7.11.220.524
2c6iDT1Cyclin-dependent kinase 22.7.11.220.523
3qu0X40Cyclin-dependent kinase 22.7.11.220.523
4fkj11KCyclin-dependent kinase 22.7.11.220.522
2w1hL0FCyclin-dependent kinase 22.7.11.220.521
4acm7YGCyclin-dependent kinase 22.7.11.220.521
2b52D42Cyclin-dependent kinase 22.7.11.220.520
1y91CT9Cyclin-dependent kinase 22.7.11.220.519
2r3mSCXCyclin-dependent kinase 22.7.11.220.519
2duv371Cyclin-dependent kinase 22.7.11.220.518
2uzoC62Cyclin-dependent kinase 22.7.11.220.518
3r71X86Cyclin-dependent kinase 22.7.11.220.518
3rjc06ZCyclin-dependent kinase 22.7.11.220.518
3rk708ZCyclin-dependent kinase 22.7.11.220.517
3sqq99ZCyclin-dependent kinase 22.7.11.220.517
3qtuX44Cyclin-dependent kinase 22.7.11.220.516
3ral04ZCyclin-dependent kinase 22.7.11.220.516
2vttLZDCyclin-dependent kinase 22.7.11.220.515
3lfqA28Cyclin-dependent kinase 22.7.11.220.515
4fkw62KCyclin-dependent kinase 22.7.11.220.515
2a4lRRCCyclin-dependent kinase 22.7.11.220.514
2r3iSCFCyclin-dependent kinase 22.7.11.220.513
3r7vZ02Cyclin-dependent kinase 22.7.11.220.513
3ezrEZRCyclin-dependent kinase 22.7.11.220.512
3qqlX03Cyclin-dependent kinase 22.7.11.220.512
3rpv26ZCyclin-dependent kinase 22.7.11.220.512
4kd11QKCyclin-dependent kinase 22.7.11.220.512
1di8DTQCyclin-dependent kinase 22.7.11.220.511
1pxlCK4Cyclin-dependent kinase 22.7.11.220.511
3qtxX43Cyclin-dependent kinase 22.7.11.220.511
1vyzN5BCyclin-dependent kinase 22.7.11.220.510
2vthLZ2Cyclin-dependent kinase 22.7.11.220.510
1h0w207Cyclin-dependent kinase 22.7.11.220.509
3rpo24ZCyclin-dependent kinase 22.7.11.220.509
2uznC96Cyclin-dependent kinase 22.7.11.220.508
3rpy27ZCyclin-dependent kinase 22.7.11.220.508
3sw719KCyclin-dependent kinase 22.7.11.220.508
2b55D31Cyclin-dependent kinase 22.7.11.220.507
3rk507ZCyclin-dependent kinase 22.7.11.220.507
3qqkX02Cyclin-dependent kinase 22.7.11.220.506
3rahO1ZCyclin-dependent kinase 22.7.11.220.505
4ez30S0Cyclin-dependent kinase 22.7.11.220.505
3qtzX42Cyclin-dependent kinase 22.7.11.220.504
3qxoX65Cyclin-dependent kinase 22.7.11.220.504
1ke7LS3Cyclin-dependent kinase 22.7.11.220.503
1oiqHDUCyclin-dependent kinase 22.7.11.220.503
1oirHDYCyclin-dependent kinase 22.7.11.220.503
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.503
3qruX19Cyclin-dependent kinase 22.7.11.220.503
3r8vZ62Cyclin-dependent kinase 22.7.11.220.503
3pxyJWSCyclin-dependent kinase 22.7.11.220.502
1pyePM1Cyclin-dependent kinase 22.7.11.220.501
2r3o2SCCyclin-dependent kinase 22.7.11.220.500
3r8pZ46Cyclin-dependent kinase 22.7.11.220.500
4nj32KDCyclin-dependent kinase 22.7.11.220.500
3wblPDYCyclin-dependent kinase 22.7.11.220.499
1ke9LS5Cyclin-dependent kinase 22.7.11.220.498
1oguST8Cyclin-dependent kinase 22.7.11.220.498
3r73X87Cyclin-dependent kinase 22.7.11.220.498
4bcmT7ZCyclin-dependent kinase 22.7.11.220.498
2r3r6SCCyclin-dependent kinase 22.7.11.220.497
2vu3LZECyclin-dependent kinase 22.7.11.220.497
3ig7EFPCyclin-dependent kinase 22.7.11.220.497
4fks46KCyclin-dependent kinase 22.7.11.220.497
1h1s4SPCyclin-dependent kinase 22.7.11.220.496
2vtqLZACyclin-dependent kinase 22.7.11.220.496
3roy22ZCyclin-dependent kinase 22.7.11.220.496
1h1r6CPCyclin-dependent kinase 22.7.11.220.495
2b53D23Cyclin-dependent kinase 22.7.11.220.495
2w17I19Cyclin-dependent kinase 22.7.11.220.494
4fko20KCyclin-dependent kinase 22.7.11.220.494
3ddqRRCCyclin-dependent kinase 22.7.11.220.493
2vtsLZCCyclin-dependent kinase 22.7.11.220.492
3r7iX9ICyclin-dependent kinase 22.7.11.220.492
3r9hZ67Cyclin-dependent kinase 22.7.11.220.492
2fvdLIACyclin-dependent kinase 22.7.11.220.491
2r64740Cyclin-dependent kinase 22.7.11.220.490
1pxpCK8Cyclin-dependent kinase 22.7.11.220.488
3raiX85Cyclin-dependent kinase 22.7.11.220.488
4eon1ROCyclin-dependent kinase 22.7.11.220.487
3r28XA0Cyclin-dependent kinase 22.7.11.220.486
2pvlP55Casein kinase II subunit alpha2.7.11.10.485
3qwkX62Cyclin-dependent kinase 22.7.11.220.484
3r1sX73Cyclin-dependent kinase 22.7.11.220.484
3rm618ZCyclin-dependent kinase 22.7.11.220.484
1dm2HMDCyclin-dependent kinase 22.7.11.220.483
3unk0BYCyclin-dependent kinase 22.7.11.220.483
4fx360KCyclin-dependent kinase 22.7.11.220.483
1b39ATPCyclin-dependent kinase 22.7.11.220.482
1vyw292Cyclin-dependent kinase 22.7.11.220.482
3le62BZCyclin-dependent kinase 22.7.11.220.482
2bheBRYCyclin-dependent kinase 22.7.11.220.480
2r3fSC8Cyclin-dependent kinase 22.7.11.220.480
3pj8404Cyclin-dependent kinase 22.7.11.220.480
4fkv61KCyclin-dependent kinase 22.7.11.220.480
1e1xNW1Cyclin-dependent kinase 22.7.11.220.478
3rm719ZCyclin-dependent kinase 22.7.11.220.478
1hckATPCyclin-dependent kinase 22.7.11.220.477
2r3gSC9Cyclin-dependent kinase 22.7.11.220.477
3my5RFZCyclin-dependent kinase 22.7.11.220.477
4dgnLU2Casein kinase II subunit alpha2.7.11.10.477
4ii5ADPCyclin-dependent kinase 22.7.11.220.477
2bhhRYUCyclin-dependent kinase 22.7.11.220.476
3qqfX07Cyclin-dependent kinase 22.7.11.220.475
2c6lDT4Cyclin-dependent kinase 22.7.11.220.474
2pvnP63Casein kinase II subunit alpha2.7.11.10.474
2iw94SPCyclin-dependent kinase 22.7.11.220.473
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.473
3ddpRC8Cyclin-dependent kinase 22.7.11.220.473
1finATPCyclin-dependent kinase 22.7.11.220.472
1y8yCT7Cyclin-dependent kinase 22.7.11.220.472
4anmWULCasein kinase II subunit alpha2.7.11.10.472
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.471
1oi9N20Cyclin-dependent kinase 22.7.11.220.470
2c6kDT2Cyclin-dependent kinase 22.7.11.220.470
3qx2X63Cyclin-dependent kinase 22.7.11.220.470
3r9nZ68Cyclin-dependent kinase 22.7.11.220.470
4dgmAGICasein kinase II subunit alpha2.7.11.10.470
1oiyN41Cyclin-dependent kinase 22.7.11.220.469
2exmZIPCyclin-dependent kinase 22.7.11.220.469
2x1nX1NCyclin-dependent kinase 22.7.11.220.468
1fvv107Cyclin-dependent kinase 22.7.11.220.467
3be9P04Casein kinase II subunit alpha2.7.11.10.466
1aq1STUCyclin-dependent kinase 22.7.11.220.465
1e9hINRCyclin-dependent kinase 22.7.11.220.463
1pkdUCNCyclin-dependent kinase 22.7.11.220.462
1qmzATPCyclin-dependent kinase 22.7.11.220.462
4bcoT6QCyclin-dependent kinase 22.7.11.220.462
2wpa889Cyclin-dependent kinase 22.7.11.220.461
3r1qX75Cyclin-dependent kinase 22.7.11.220.461
3s0o50ZCyclin-dependent kinase 22.7.11.220.461
2c69CT8Cyclin-dependent kinase 22.7.11.220.460
2wxvWXVCyclin-dependent kinase 22.7.11.220.460
2wouZZFTGF-beta receptor type-12.7.11.300.459
1h1pCMGCyclin-dependent kinase 22.7.11.220.458
2c5yMTWCyclin-dependent kinase 22.7.11.220.458
3q9xEMOCasein kinase II subunit alpha2.7.11.10.458
3qzhX69Cyclin-dependent kinase 22.7.11.220.458
2uzbC75Cyclin-dependent kinase 22.7.11.220.457
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.457
3r6xX84Cyclin-dependent kinase 22.7.11.220.457
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.456
4eok4SPCyclin-dependent kinase 22.7.11.220.456
3qtsX46Cyclin-dependent kinase 22.7.11.220.455
3qziX72Cyclin-dependent kinase 22.7.11.220.455
3ti1B49Cyclin-dependent kinase 22.7.11.220.455
2iw84SPCyclin-dependent kinase 22.7.11.220.454
3qtqX35Cyclin-dependent kinase 22.7.11.220.454
1oiuN76Cyclin-dependent kinase 22.7.11.220.453
4bcpT3CCyclin-dependent kinase 22.7.11.220.453
1unlRRCCyclin-dependent-like kinase 52.7.11.10.452
2xmyCDKCyclin-dependent kinase 22.7.11.220.452
3gxlQIGTGF-beta receptor type-12.7.11.300.452
2pvhP19Casein kinase II subunit alpha2.7.11.10.451
2r3q5SCCyclin-dependent kinase 22.7.11.220.451
1ckpPVBCyclin-dependent kinase 22.7.11.220.450
3tnwF18Cyclin-dependent kinase 22.7.11.220.450
3uli1N3Cyclin-dependent kinase 22.7.11.220.450
3w33W19Epidermal growth factor receptor2.7.10.10.450
4eos1ROCyclin-dependent kinase 22.7.11.220.450
4jajXU1Aurora kinase A2.7.11.10.450
1h1q2A6Cyclin-dependent kinase 22.7.11.220.449
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
4aua4AUCyclin-dependent kinase 62.7.11.220.449
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.449
5e8ySTUTGF-beta receptor type-22.7.11.300.449
3py0SU9Cyclin-dependent kinase 22.7.11.220.448
4eomATPCyclin-dependent kinase 22.7.11.220.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
2i40BLZCyclin-dependent kinase 22.7.11.220.447
2zjwREFCasein kinase II subunit alpha2.7.11.10.447
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.446
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3r7eX88Cyclin-dependent kinase 22.7.11.220.446
2c6mDT5Cyclin-dependent kinase 22.7.11.220.445
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.445
1fvt106Cyclin-dependent kinase 22.7.11.220.444
1xjdSTUProtein kinase C theta type2.7.11.130.444
3axwTIDCasein kinase II subunit alpha2.7.11.10.444
3r8uZ31Cyclin-dependent kinase 22.7.11.220.444
4eol1ROCyclin-dependent kinase 22.7.11.220.444
1om1IQACasein kinase II subunit alpha2.7.11.10.443
2uzdC85Cyclin-dependent kinase 22.7.11.220.443
1h0vUN4Cyclin-dependent kinase 22.7.11.220.442
1r78FMDCyclin-dependent kinase 22.7.11.220.442
3nux3NVCyclin-dependent kinase 62.7.11.220.442
3qtwX3ACyclin-dependent kinase 22.7.11.220.442
2wotZZGTGF-beta receptor type-12.7.11.300.441
3bhtMFRCyclin-dependent kinase 22.7.11.220.441
3nieANPMitogen-activated protein kinase/0.441
3nynSGVG protein-coupled receptor kinase 62.7.11.160.441
3qrtX14Cyclin-dependent kinase 22.7.11.220.441
4eooATPCyclin-dependent kinase 22.7.11.220.441
4eor4SPCyclin-dependent kinase 22.7.11.220.441
1vjy460TGF-beta receptor type-12.7.11.300.440
3ggfGVDSerine/threonine-protein kinase 26/0.440
3hmm855TGF-beta receptor type-12.7.11.300.440
3r8zZ63Cyclin-dependent kinase 22.7.11.220.440
3rpr25ZCyclin-dependent kinase 22.7.11.220.440